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Articles 1 - 25 of 25
Full-Text Articles in Medicine and Health Sciences
Computed Tomography To Assess Pulmonary Injury Associated With Concurrent Chemo-Radiotherapy For Inoperable Non-Small Cell Lung Cancer, Galit Aviram, Edward Yu, Patricia Tai, Michael Lefcoe
Computed Tomography To Assess Pulmonary Injury Associated With Concurrent Chemo-Radiotherapy For Inoperable Non-Small Cell Lung Cancer, Galit Aviram, Edward Yu, Patricia Tai, Michael Lefcoe
Edward Yu
OBJECTIVE: To characterize serial computed tomography (CT) findings of pulmonary injury after a uniform regimen of concurrent chemo-radiotherapy in inoperable non-small cell lung cancer, and to compare the radiation-induced lung toxicity with other concurrent chemo-radiation regimens. METHODS: Twenty-four patients with advanced non-small cell lung cancer received 2 induction cycles of cisplatin and vinblastine, followed by 2 further cycles of cisplatin and vinblastine, concurrent with 60 Gy radiation at 2 Gy per fraction. Radiation-induced lung injury in the acute and chronic phases was assessed by serial CT scans and compared with preradiation baseline scans. Acute radiation pneumonitis was evaluated using the …
Who Should Foot The Bill For Continuing Review Of Research?, Charles Weijer
Who Should Foot The Bill For Continuing Review Of Research?, Charles Weijer
Charles Weijer
No abstract provided.
Concentric Retinitis Pigmentosa: Clinicopathologic Correlations, Ann Milam, Elaine De Castro, Julie Smith, Wai-Xing Tang, Sinoj John, Michael Gorin, Edwin Stone, Gustavo Aguirre, Samuel Jacobson
Concentric Retinitis Pigmentosa: Clinicopathologic Correlations, Ann Milam, Elaine De Castro, Julie Smith, Wai-Xing Tang, Sinoj John, Michael Gorin, Edwin Stone, Gustavo Aguirre, Samuel Jacobson
Gustavo D. Aguirre, VMD, PhD
Fine Mapping Of Canine Xlpra Establishes Homology Of The Human And Canine Rp3 Intervals, Qi Zhang, Gregory M. Acland, Barbara Zangerl, J. L. Johnson, Zuohua Mao, Caroline Zeiss, Elaine A. Ostrander, Gustavo D. Aguirre
Fine Mapping Of Canine Xlpra Establishes Homology Of The Human And Canine Rp3 Intervals, Qi Zhang, Gregory M. Acland, Barbara Zangerl, J. L. Johnson, Zuohua Mao, Caroline Zeiss, Elaine A. Ostrander, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Cloning Of Canine Γ-Tubulin (Tubg1) Cdna And Mapping To Cfa9, Duska J. Sidjanin, F Xue, J Mcelwee, Jennifer L. Johnson, C Holmgren, Cathryn S. Mellersh, Elaine A. Ostrander, Gregory M. Acland, Gustavo D. Aguirre
Cloning Of Canine Γ-Tubulin (Tubg1) Cdna And Mapping To Cfa9, Duska J. Sidjanin, F Xue, J Mcelwee, Jennifer L. Johnson, C Holmgren, Cathryn S. Mellersh, Elaine A. Ostrander, Gregory M. Acland, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
No abstract provided.
Monte Carlo Simulations And Measurement Of Dna Damage From X-Ray-Triggered Auger Cascades In Iododeoxyuridine (Iudr), S. Karnas, V. Moiseenko, E. Yu, P. Truong, J. Battista
Monte Carlo Simulations And Measurement Of Dna Damage From X-Ray-Triggered Auger Cascades In Iododeoxyuridine (Iudr), S. Karnas, V. Moiseenko, E. Yu, P. Truong, J. Battista
Edward Yu
We investigated the DNA damage from Auger electrons emitted from incorporated stable iodine (127I), following photoelectric absorption of external x-rays. The effectiveness of the Auger electrons in producing DNA double-strand breaks (DSB) was determined theoretically, using Monte Carlo simulations of the radiation physics and chemistry, and was shown to be in reasonable agreement with DNA damage measured using the comet assay. The DSB yields were measured in CHO cells for 60Co (as a non-Auger-promoting radiation) and for tungsten-filtered 100 kVp x-rays capable of producing Auger electron emission. The theoretical study showed that on average, 2.5 Auger electrons were emitted for …
Minimal Risk And Its Implications, Charles Weijer
Minimal Risk And Its Implications, Charles Weijer
Charles Weijer
No abstract provided.
Using Treatment Interruptions To Palliate The Toxicity From Concurrent Chemoradiation For Limited Small Cell Lung Cancer Decreases Survival And Disease Control, Gregory Videtic, Karen Fung, Anna Tomiak, Larry Stitt, A. Dar, Pauline Truong, Edward Yu, Mark Vincent, Walter Kocha
Using Treatment Interruptions To Palliate The Toxicity From Concurrent Chemoradiation For Limited Small Cell Lung Cancer Decreases Survival And Disease Control, Gregory Videtic, Karen Fung, Anna Tomiak, Larry Stitt, A. Dar, Pauline Truong, Edward Yu, Mark Vincent, Walter Kocha
Edward Yu
BACKGROUND AND PURPOSE: We analyzed the impact on survival outcomes of treatment interruptions due to toxicity arising during the concurrent phase of chemotherapy/radiotherapy (ChT/RT) for our limited-stage small-cell cancer (LSCLC) population over the past 10 years. MATERIALS AND METHODS: From 1989 to 1999, 215 patients received treatment for LSCLC, consisting of six cycles of alternating cyclophosphamide/doxorubicin or epirubicin/vincristine (CAV; CEV) and etoposide/cisplatin (EP). Thoracic RT was started with EP at either the second or third cycle (85% of patients). RT dose was either 40 Gy in 15 fractions over 3 weeks or 50 Gy in 25 fractions over 5 weeks, …
Should Physicians Accept Gifts From Their Patients? No: Gifts Debase The True Value Of Care, Charles Weijer
Should Physicians Accept Gifts From Their Patients? No: Gifts Debase The True Value Of Care, Charles Weijer
Charles Weijer
No abstract provided.
The Corporate Practice Of Medicine: Competition And Innovation In Health Care (Book Review), Linda Treiber
The Corporate Practice Of Medicine: Competition And Innovation In Health Care (Book Review), Linda Treiber
Linda A. Treiber
Review of the book "The Corporate Practice of Medicine: Competition and Innovation in Health Care," by James C. Robinson
Informing Patients Of Uncertainty In Clinical Trials, S. Halpern, J. Karlawish, Charles Weijer
Informing Patients Of Uncertainty In Clinical Trials, S. Halpern, J. Karlawish, Charles Weijer
Charles Weijer
No abstract provided.
Practice Guideline On Prophylactic Cranial Irradiation In Small-Cell Lung Cancer, Jaro Kotalik, Edward Yu, Barbara Markman, William Evans
Practice Guideline On Prophylactic Cranial Irradiation In Small-Cell Lung Cancer, Jaro Kotalik, Edward Yu, Barbara Markman, William Evans
Edward Yu
Purpose: To develop an evidence-based clinical practice guideline that would address the following questions: (a) What is the role of prophylactic cranial irradiation (PCI) in patients with limited or extensive stage small-cell lung cancer (SCLC) who have achieved complete remission in response to induction therapy (chemotherapy or chemoradiotherapy)? (b) What dose and fractionation schedules of PCI are optimal? (c) Does the use of PCI in patients with SCLC in complete remission affect quality of life? Survival, disease-free survival, quality of life, and adverse effects were the outcomes of interest. Methods and materials: A systematic review of the published literature was …
Continuing Review Of Research Approved By Canadian Research Ethics Boards, Charles Weijer
Continuing Review Of Research Approved By Canadian Research Ethics Boards, Charles Weijer
Charles Weijer
No abstract provided.
The Ethics Wars: Disputes Over International Research, Charles Weijer, James Anderson
The Ethics Wars: Disputes Over International Research, Charles Weijer, James Anderson
Charles Weijer
The effort to revise the Declaration of Helsinki and the CIOMS Guidelines has sparked a sometimes vitriolic debate centering on the use of placebo controls.
Gene Therapy Restores Vision In A Canine Model Of Childhood Blindness, Gregory M. Acland, Gustavo D. Aguirre, Jharna Ray, Qi Zhang, Tomas S. Aleman, Artur V. Cideciyan, Susan E. Pearce-Kelling, Vibha Anand, Yong Zeng, Albert M. Maguire, Samuel G. Jacobson, William W. Hauswirth, Jean Bennett
Gene Therapy Restores Vision In A Canine Model Of Childhood Blindness, Gregory M. Acland, Gustavo D. Aguirre, Jharna Ray, Qi Zhang, Tomas S. Aleman, Artur V. Cideciyan, Susan E. Pearce-Kelling, Vibha Anand, Yong Zeng, Albert M. Maguire, Samuel G. Jacobson, William W. Hauswirth, Jean Bennett
Gustavo D. Aguirre, VMD, PhD
Evaluation Of Retinal Photoreceptors And Pigment Epithelium In A Female Carrier Of Choroideremia, Nasreen Syed, Julie E. Smith, Sinoj K. John, Miguel C. Seabra, Gustavo D. Aguirre, Ann H. Milam
Evaluation Of Retinal Photoreceptors And Pigment Epithelium In A Female Carrier Of Choroideremia, Nasreen Syed, Julie E. Smith, Sinoj K. John, Miguel C. Seabra, Gustavo D. Aguirre, Ann H. Milam
Gustavo D. Aguirre, VMD, PhD
Aggregated Dsred-Tagged Cx43 And Over-Expressed Cx43 Are Targeted To Lysosomes In Human Breast Cancer Cells, H. Qin, Q. Shao, Daniel Belliveau, D. Laird
Aggregated Dsred-Tagged Cx43 And Over-Expressed Cx43 Are Targeted To Lysosomes In Human Breast Cancer Cells, H. Qin, Q. Shao, Daniel Belliveau, D. Laird
Daniel J. Belliveau
To investigate if either wild-type or aggregated Cx43 is abnormally targeted to lysosomes in human breast tumor cells, we examined the fate of DsRed-tagged Cx43 and over-expressed Cx43 in communication-deficient HBL-100 and MDA-MB-231 cells. DsRed-tagged Cx43 was assembled into gap junctions in control normal rat kidney cells that express endogenous Cx43 but not in Cx43-negative HBL-100 cells. However, when HBL-100 cells were engineered to coexpress wild-type Cx43 a population of DsRed-tagged Cx43 was rescued and assembled into gap junctions. Co-expression of wild-type Cx26 failed to rescue the assembly of DsRed-tagged Cx43 into gap junctions. Immunolocalization studies revealed that DsRed-tagged Cx43 …
The Three Critical Components In The Conservative Treatment Of Juvenile Osteochondritis Dissecans (Jocd): Physician, Parent, And Child, Bernard Cahill, Sara Ahten
The Three Critical Components In The Conservative Treatment Of Juvenile Osteochondritis Dissecans (Jocd): Physician, Parent, And Child, Bernard Cahill, Sara Ahten
Sara M. Ahten
No abstract provided.
En Forma Después De Los 50, Francisco Soto Mas
En Forma Después De Los 50, Francisco Soto Mas
Francisco Soto Mas
De forma habitual uno se olvida de la salud, y sólo nos acordamos de ella cuando la echamos de menos. El trabajo, la familia y en general, la falta de tiempo son las razones esgrimidas por aquellos que no se mantienen físicamente activos. Lo recomendable es hacer ejercicio desde pequeños, pero para aquellos que llegan tarde, lo que pretendemos con este libro es concienciarles de que todavía están a tiempo de ponerse en forma. A través de una doble visión, por un lado la de la medicina y por otro la educación física, hemos intentado informar sobre las enfermedades más …
The Research Subject As Entrepreneur, James Anderson, Charles Weijer
The Research Subject As Entrepreneur, James Anderson, Charles Weijer
Charles Weijer
No abstract provided.
Hospital Policy On Appropriate Use Of Life-Sustaining Treatment, Peter Singer, Geoff Barker, Kerry Bowman, Christine Harrison, Philip Kernerman, Judy Kopelow, Neil Lazar, Charles Weijer, Stephen Workman
Hospital Policy On Appropriate Use Of Life-Sustaining Treatment, Peter Singer, Geoff Barker, Kerry Bowman, Christine Harrison, Philip Kernerman, Judy Kopelow, Neil Lazar, Charles Weijer, Stephen Workman
Charles Weijer
OBJECTIVE: To describe the issues faced, and how they were addressed, by the University of Toronto Critical Care Medicine Program/Joint Centre for Bioethics Task Force on Appropriate Use of Life-Sustaining Treatment. The clinical problem addressed by the Task Force was dealing with requests by patients or substitute decision makers for life-sustaining treatment that their healthcare providers believe is inappropriate.
DESIGN: Case study.
SETTING: The University of Toronto Joint Centre for Bioethics/Critical Care Medicine Program Task Force on Appropriate Use of Life-Sustaining Treatment.
PARTICIPANTS: The 24-member Task Force included physician and nursing leaders from five critical care units, bioethicists, a legal …
Trial By Error, Charles Weijer
Age And Neuropsychological Status Following Exposure To Violent Nonimpact Acceleration Forces In Mvas, James Sweeney, Andrew Johnson
Age And Neuropsychological Status Following Exposure To Violent Nonimpact Acceleration Forces In Mvas, James Sweeney, Andrew Johnson
Andrew M. Johnson
Performance on the Halstead-ReitanNeuropsychological Test Battery (HRB) was analyzed for 33 ind viduals, aged 20 to 69, who had been subjected to violent aceeleration forces in motor vehicle accidents . Age was considered as a continuous variable and correlated with single and compos ite HRB measures. With the one exception of the Left Neuropsychological Deficit Scale (NDS) score, agere lated de cline was consistently demonstrated by com positeHRB scores (i.e., Gen eralNDS, Right NDS, Level of Performance NDS, Pathognomonic SignNDS, Pattern NDS, Right-Left Differ enceNDS, and Halstead Impairment Index). In contrast, most single non-composite HRB measures did not refleet a …
Assessment Of Side Effects In Patients With Chronic Hepatitis C Receiving Combination Therapy, Donna Zucker, Barry Miller
Assessment Of Side Effects In Patients With Chronic Hepatitis C Receiving Combination Therapy, Donna Zucker, Barry Miller
Donna M. Zucker
This purpose of this descriptive study is to review the adverse effects of combination therapy, interferon alfa-2b and ribavirin, in a sample of patients with chronic hepatitis C who were part of a larger multi-center trial. The sample (n=13) was drawn from one hepatology practice in the northeastern U.S. This secondary analysis reported sums, frequencies, means and standard deviations for the sample. Patients who received 600 mg. ribavirin per day in addition to interferon alfa-2B (Arm A) showed a mean of 9.5 different types of side effects. Patients who received 1000-1200 mg of ribavirin in addition to interferon alfa-2B (Arm …
Adenoviral Vector-Mediated Ss-Glucuronidase Cdna Transfer To Treat Mps Vii Rpe In Vitro, Maria E. Verdugo, Virginia Scarpino, Phillipe Moullier, M Haskins, Gustavo D. Aguirre, Jharna Ray
Adenoviral Vector-Mediated Ss-Glucuronidase Cdna Transfer To Treat Mps Vii Rpe In Vitro, Maria E. Verdugo, Virginia Scarpino, Phillipe Moullier, M Haskins, Gustavo D. Aguirre, Jharna Ray
Gustavo D. Aguirre, VMD, PhD