Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Institution
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Anti-Gag Cytolytic T Lymphocytes Specific For An Alternative Translational Reading Frame-Derived Epitope And Resistance Versus Susceptibility To Retrovirus-Induced Murine Aids In F1 Mice, Shawn-Marie Mayrand, Patricia A. Healy, Bruce E. Torbett, William R. Green
Anti-Gag Cytolytic T Lymphocytes Specific For An Alternative Translational Reading Frame-Derived Epitope And Resistance Versus Susceptibility To Retrovirus-Induced Murine Aids In F1 Mice, Shawn-Marie Mayrand, Patricia A. Healy, Bruce E. Torbett, William R. Green
Dartmouth Scholarship
Murine AIDS (MAIDS) develops in susceptible mouse strains after infection with the LP-BM5 murine leukemia virus complex that contains causative defective, and ecotropic helper, retroviruses. We previously demonstrated that the MAIDSresistant H-2d strains BALB/cByJ and C57BL/KsJ generate MHC class I (Kd ) restricted virus-specific CD81 cytolytic T lymphocytes (CTLs) that lyse cells expressing either defective or ecotropic gag proteins. In contrast, the congenic BALB.B and closely related C57BL/6J MAIDS-susceptible H-2b strains were unable to serve as a source of gag-specific CTLs (Schwarz and Green, 1994), suggesting that anti-gag CTLs might provide a basis for resistance to MAIDS. Although its susceptibility …
Evaluation Of Immunogenicity Of Pasterurella Haemolytica Serotypes In Experimental Models, K. Serdar Di̇ker, Mehmet Akan, Osman Kaya
Evaluation Of Immunogenicity Of Pasterurella Haemolytica Serotypes In Experimental Models, K. Serdar Di̇ker, Mehmet Akan, Osman Kaya
Turkish Journal of Veterinary & Animal Sciences
The immunogenicity of Pasteurella haemolyticaserotypes was investigated in an experimental animal model. Rabbits were immunized with bacterins and leukotoxins of selected serotypes of P. haemolytica,and the IgG level and antileukotoxin activities of immune sera were measured. The highest IgG levels against A1, A2, A7 and T4 antigens were detected in rabbits receiving polyvalent combined (bacterin plus leukotoxin) immunogens. Monovalent combined immunogens induced high antibody titers against homologous serotypes, but low titers against heterologous serotypes. Serotype A1 and A7 were found to be more antigenic than A2 and T4. The highest antileukotoxin activity in monovalent groups was detected in A1 and …