Medicine and Health Sciences Commons^™

Jefferson Alumni Bulletin – Volume Xlix, Number 1, December 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume , Number, December 1999 Bringing Cancer Knowledge From the Laboratory to the Bedside, Page 4 Increasing the Effectiveness of Radiotherapies, Page 6 Molecular Pathways of Apoptosis are Discovered, Page 13 Structural Approaches to New Therapies: A Jefferson Symposium, Page 14 Method to Isolate Stem Cells is Found Here, Page 18 Learning Environment May Prevent Alzheimer’s, Page 21 Jefferson Ranks in the Top Quarter of All Medical Schools in Training Grants, Page 21 Book about the Art Collection is Now Available, Page 25 JAMA Study Proves That Jefferson Brings Family Physicians to Underserved Rural America, Page …

Ethnic Variability In The Treatment Of Pain, Rafael A. Ortega, Benjamin A. Youdelman, Richard C. Havel

Department of Surgery Faculty Papers

Ethnicity has been shown to be an important determinant of behavior during illness, particularly when a painful condition is present. Studies have shown that pain may be undertreated among different ethnic groups of patients. Whereas individual variations in the reaction to pain occur, available data do not support racial and/or ethnic differences in the perception of pain, leaving no justification for this discrepancy in treatment. Regardless of ethnicity, inadequate treatment of pain has been known for some time and has been referred to in recent literature as "oligoanalgesia." Lack of understanding of different ethnic and cultural groups can lead to …

Nurses Alumni Association Bulletin, Fall 1999, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers

Nursing Alumni Bulletins

1999-2000 Meeting Dates Calendar

2000 Annual Luncheon-Meeting Notice

Fall Social

Officers and Committee Chairs

Bulletin Publication Committee

The President's Message

Treasurer's Report

News About Our Graduates

History of The Nurses Relief Fund

Nurses Wear White

Memories of My Nurse Training Days

Scholarship Funds At Work

Second Janet C. Hindson Award

Rib Ticklers

Happy Birthday

Fiftieth Anniversary

Resume Alumni Association Meetings

Alumni Office News

Committee Reports

• Bulletin
• Nominating
• Relief Fund
• Scholarship
• Social
• Development

Luncheon Photos

In Memoriam, Names of Deceased Graduates

Class News

Janet C. Hindson Memorial Award (How to Submit Names)

Scholarship Fund Application

Certification Reimbursement Application

Relief Fund Application …

The Review - Summer/Fall 1999

Jefferson Review

IN THIS ISSUE :

• Why I Hate Alumni Magazines - 2
• CHP: 30 Years and Counting - 3
• Diagnostic Imaging Set to Enter Next Millenium with a Clear Image of Its Future - 6
• Alumni Reunion Highlights - 8
• Alumni Notes - 9
• Alumni Update - 1 0
• College Notes - 1 2
• 21 st - Century Resumes: New Formats for Going after the Job Market - 1 3

Jefferson Alumni Bulletin – Volume Xlviii, Number 3, September 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 3, September 1999 Commencement and Reunions, Page 4 A Class Day to Remember, Page 8 Seeking a Balance among the Three Legs of the Stool, Page 9 U.S. News Ranks Jefferson One of Best in Nation, Page 14 Smullens is Named Chief Medical Officer of JHS, Page 14 Gene Repair Molecules Are Created, Page 17 Mary Monteith Honored on Her Retirement, Page 18 Bacharach Appointed Associate Dean for Alumni Relations, Page 18 Annual Giving, Page 19 Heckman, Canale in National Orthopaedics Posts, Page 53 Morrow Directs Cancer Department of ACS, Page 59 Andriole …

Phosphoinositide-Ap-2 Interactions Required For Targeting To Plasma Membrane Clathrin-Coated Pits., I Gaidarov, James H. Keen

Department of Microbiology and Immunology Faculty Papers

The clathrin-associated AP-2 adaptor protein is a major polyphosphoinositide-binding protein in mammalian cells. A high affinity binding site has previously been localized to the NH(2)-terminal region of the AP-2 alpha subunit (Gaidarov et al. 1996. J. Biol. Chem. 271:20922-20929). Here we used deletion and site- directed mutagenesis to determine that alpha residues 21-80 comprise a discrete folding and inositide-binding domain. Further, positively charged residues located within this region are involved in binding, with a lysine triad at positions 55-57 particularly critical. Mutant peptides and protein in which these residues were changed to glutamine retained wild-type structural and functional characteristics by …

Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …

Jefferson Alumni Bulletin – Volume Xlviii, Number 2, June 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 2, June 1999 Meeting Challenges from the Start, Page 4 Developing the Curriculum, Page 5 Building a Campus, Page 6 Leaders in Their Fields: The 19th Century, Page 12 In the Nation’s Service, Page 11 Keeping Pace for the 20th Century, Page 12 A Comprehensive Medical School, Page 14 How Do We Monitor the Quality of the Education? Page 17 The Jefferson Health System, Page 20 Education in the Health System, Page 22 Teaching under Managed Care, Page 24 A Student’s Perspective, Page 26 JeffHOPE: Learning and Caring Go Hand in Hand, Page …

1999 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

Signal Transducer And Activator Of Transcription (Stat)5 Activation By Bcr/Abl Is Dependent On Intact Src Homology (Sh)3 And Sh2 Domains Of Bcr/Abl And Is Required For Leukemogenesis., M Nieborowska-Skorska, M A Wasik, A Slupianek, P Salomoni, T Kitamura, B Calabretta, T Skorski

Department of Microbiology and Immunology Faculty Papers

Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/ ABL-expressing cells, but the mechanisms and functional consequences of such activation are unknown. We show here that BCR/ABL induces phosphorylation and activation of STAT5 by a mechanism that requires the BCR/ABL Src homology (SH)2 domain and the proline-rich binding site of the SH3 domain. Upon expression in 32Dcl3 growth factor-dependent myeloid precursor cells, STAT5 activation-deficient BCR/ABL SH3+SH2 domain mutants functioned as tyrosine kinase and activated Ras, but failed to protect from apoptosis induced by withdrawal of interleukin 3 and/or serum and did not induce leukemia in severe combined …

Radiculopathy And Myelopathy At Segments Adjacent To The Site Of A Previous Anterior Cervical Arthrodesis., Alan S. Hilibrand, Gregory D. Carlson, M A Palumbo, P K Jones, H H Bohlman

Rothman Institute Faculty Papers

BACKGROUND: We studied the incidence, prevalence, and radiographic progression of symptomatic adjacent-segment disease, which we defined as the development of new radiculopathy or myelopathy referable to a motion segment adjacent to the site of a previous anterior arthrodesis of the cervical spine.

METHODS: A consecutive series of 374 patients who had a total of 409 anterior cervical arthrodeses for the treatment of cervical spondylosis with radiculopathy or myelopathy, or both, were followed for a maximum of twenty-one years after the operation. The annual incidence of symptomatic adjacent-segment disease was defined as the percentage of patients who had been disease-free at …

Jefferson Alumni Bulletin – Volume Xlviii, Number 1, March 1999

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVIII, Number 1, March 1999 Otolaryngology-Head and Neck Surgery, Page 4 Gene Therapy in a Liquid: an Easier Treatment, Page 10 Gene Repair Technique is Developed, Page 10 Moving Closer to Gene Therapy for Lung Cancer, Page 11 Frankford Hospital Joins Jefferson Health System, Page 14 Dean Gonnella Receives AAMC’s Flexner Award, Page 17

Integrin-Dependent Control Of Translation: Engagement Of Integrin Alphaiibbeta3 Regulates Synthesis Of Proteins In Activated Human Platelets., Ravinder Pabla, Andrew S. Weyrich, Dan A. Dixon, Paul F. Bray, Thomas M. Mcintyre, Stephen M. Prescott, Guy A. Zimmerman

Cardeza Foundation for Hematologic Research

Integrins are widely expressed plasma membrane adhesion molecules that tether cells to matrix proteins and to one another in cell-cell interactions. Integrins also transmit outside-in signals that regulate functional responses of cells, and are known to influence gene expression by regulating transcription. In previous studies we found that platelets, which are naturally occurring anucleate cytoplasts, translate preformed mRNA transcripts when they are activated by outside-in signals. Using strategies that interrupt engagement of integrin alphaIIbbeta3 by fibrinogen and platelets deficient in this integrin, we found that alphaIIbbeta3 regulates the synthesis of B cell lymphoma 3 (Bcl-3) when platelet aggregation is induced …

Department Of Radiology-Annual Executive Summary Report-July 1, 1998 To June 30, 1999, David C. Levin, M.D.

Department of Radiology Administrative Documents and Reports

102 page Department of Radiology Annual Executive Summary Report, July 1, 1998 to June 30, 1999, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.