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Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
Genetic Polymorphism Of The Ipah Multicopy Antigen Gene In Shigella Spps. And Enteroinvasive Escherichia Coli, Jerry M. Buysse, Antoinette B. Hartman, Nancy Strockbine, Malabi Venkatesan
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The ipaH loci comprise a multicopy antigen gene family unique to Shigella species and enteroinvasive Escherichia coli (EIEC). DNA probes derived from the Shigella flexneri stereotype 5 ipaH7.8 gene were used to compare the molecular arrangement of ipaH alleles in a variety of Shigella and EIEC strains. Multiple copies of ipaH-homologous sequences were detected in all invasion plasmids examined. Oligonucleotide probes covering discrete 24 bp segments of the ipaH7.8 gene and sequences flanking the ipaH4.5 (probe H25) and ipaH2.5 (probe H24) loci were used to define the extent of homology among invasion plasmid copies of …