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Full-Text Articles in Medicine and Health Sciences

Leader-Member Exchange And Supervisor Career Mentoring As Complementary Constructs In Leadership Research, Terri Scandura Nov 1994

Leader-Member Exchange And Supervisor Career Mentoring As Complementary Constructs In Leadership Research, Terri Scandura

Terri A. Scandura

No abstract provided.


The Forms And Limits Of Medical Ethics, Barry Hoffmaster Oct 1994

The Forms And Limits Of Medical Ethics, Barry Hoffmaster

C. Barry Hoffmaster

As medical ethics has evolved over the past several decades, it has come to be regarded as a domain of applied ethics, that is, the application of a rationally based, philosophical theory to moral problems in health care. But an array of difficulties arise in the attempt to apply general moral theories or norms to concrete problems, difficulties that expose the incompleteness and indeterminacy of philosophical moral theory. The doubtful ability of applied ethics to be practically helpful has led to the development of two main competitors. One is the attempt to reprise and rehabilitate the tradition of moral casuistry, …


Biomedical Ethics In A Canadian Context, Charles Weijer Sep 1994

Biomedical Ethics In A Canadian Context, Charles Weijer

Charles Weijer

No abstract provided.


Redistribution Of Insoluble Interphotoreceptor Matrix Components During Photoreceptor Differentiation In The Mouse Retina, Kristina Mieziewska, Agoston Szel, Theo Van Veen, Gustavo D. Aguirre, Nancy Philp Jun 1994

Redistribution Of Insoluble Interphotoreceptor Matrix Components During Photoreceptor Differentiation In The Mouse Retina, Kristina Mieziewska, Agoston Szel, Theo Van Veen, Gustavo D. Aguirre, Nancy Philp

Gustavo D. Aguirre, VMD, PhD

The development of the nervous-system is largely influenced by the extracellular matrix (ECM). In the neural retina, the photoreceptors are surrounded by a unique ECM, the interphotoreceptor matrix (IPM). The IPM plays a central and possibly crucial role in the development, maintenance and specific function of the photoreceptors. Therefore, the characterization of IPM components is necessary to understand the mechanisms regulating photoreceptor differentiation.

The IPM in the mouse retina was examined during photoreceptor morphogenesis with the monoclonal antibody (MAb) F22, which recognizes a 250 kDa component of the interphotoreceptor matrix. The binding pattern of MAb F22 revealed a striking redistribution …


Momento Mori, Charles Weijer Apr 1994

Momento Mori, Charles Weijer

Charles Weijer

No abstract provided.


The Duty To Exclude: Excluding People At Undue Risk From Research, Charles Weijer, Abraham Fuks Mar 1994

The Duty To Exclude: Excluding People At Undue Risk From Research, Charles Weijer, Abraham Fuks

Charles Weijer

The clinical trial is the major investigational tool of clinical medicine. Two recent reports highlight the fact that the most often quoted mechanisms for the protection of research subjects, viz., research ethics board review and eligibility criteria, are insufficient to achieve this end. In this paper, we argue that the prime mechanism for the protection of persons in clinical trials should be the clinical judgement of the physician-investigator. The clinical investigator has a duty to protect subjects from both harm and undue risk. It is argued that the clinical investigator has a duty to screen for, and exclude, potential research …


Plasma Lipid Changes In Prcd-Affected And Normal Miniature Poodles Given Oral Supplements Of Linseed Oil. Indications For The Involvement Of N-3 Fatty Acids In Inherited Retinal Degenerations, Robert E. Anderson, Maureen B. Maude, Gregory M. Acland, Gustavo D. Aguirre Jan 1994

Plasma Lipid Changes In Prcd-Affected And Normal Miniature Poodles Given Oral Supplements Of Linseed Oil. Indications For The Involvement Of N-3 Fatty Acids In Inherited Retinal Degenerations, Robert E. Anderson, Maureen B. Maude, Gregory M. Acland, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

It has previously been shown that miniature poodles with regressive rod-cone degeneration (PRCD) have lower plasma levels of docosahexaenoic acid (22:6n-3) than normal poodles and it has been suggested that affected animals have a defect in the motabolism of 22:6n-3. To test this hypothesis in vivo, PRCD affected and normal miniature poodles were given daily oral supplements of linsee oil (enriched in 19:3n-3, 20:5n-3, and 22:5n-3 between affected and normal dogs. Therefore, there appears to be no abnormality in the elongation and desaturation system that takes 18:3n-3 and 22:5n-3. Surprisingly, the plasma level of 22:6n-3 was reduced in both groups …


Cortical Type 2 Astrocytes Are Not Dye Coupled Nor Do They Express The Major Gap Junction Genes Found In The Central Nervous System, Daniel Belliveau, C. Naus Dec 1993

Cortical Type 2 Astrocytes Are Not Dye Coupled Nor Do They Express The Major Gap Junction Genes Found In The Central Nervous System, Daniel Belliveau, C. Naus

Daniel J. Belliveau

The O‐2A progenitor cell first described from the rat optic nerve is a bipotential precursor of oligodendrocytes and type 2 astrocytes. Each cell expresses specific markers that distinguish them as unique cell types. O‐2A progenitors cultured in high serum preferentially differntiate into type 2 astrocytes and when exposed to defined medium or low serum develop along the oligodendrocyte lineage. We analyzed the gap junction gene expression of type 2 astrocytes to determine if they are coupled to form a syncytium, like their type 1 astrocyte counterparts. Dye coupling experiments demonstrated that cortical type 2 astrocytes are not coupled, while type …


Decreased Opsin Mrna And Immunoreactivity In Progressive Rod-Cone Degeneration (Prcd): Cytochemical Studies Of Early Disease And Degeneration, Jun Huang, Marie-Françoise Chesselet, Gustavo Aguirre Dec 1993

Decreased Opsin Mrna And Immunoreactivity In Progressive Rod-Cone Degeneration (Prcd): Cytochemical Studies Of Early Disease And Degeneration, Jun Huang, Marie-Françoise Chesselet, Gustavo Aguirre

Gustavo D. Aguirre, VMD, PhD

Opsin mRNA level and immunoreactivity were examined by in situ hybridization and immunocytochemistry in normal and progressive rod cone degeneration (prcd)-affected dogs. In situ hybridization used 35S- and/or 3 H-labeled bovine opsin cRNA probes; immunocytochemistry used six monoclonal mouse anti-bovine opsin antibodies (MAb1) that are specific to different regions of the N-terminal, loop v-vi and the C-terminal domains. Optimal labeling and histological resolution at the single cell level were achieved with semi-thin sections of DGD wax-embedded tissues; it was possible to correlate the cytochemical observations with the disease staging in topographically defined regions that exhibited different disease severity. In early …