Medicine and Health Sciences Commons^™

Comparisons Of Eating Disorder Presentation, Research Participation, And Treatment Utilization Between Racial And Ethnic Groups Of College Women With Eating Disorders, Grace Monterubio

Arts & Sciences Electronic Theses and Dissertations

The inclusion of racial and ethnic minority individuals in research is imperative in furthering generalizable and comprehensive research on eating disorder (ED) populations and improving the disparities for minorities with EDs. The current study investigates such disparities by 1) assessing the presentation of EDs and comorbidities across racial and ethnic groups, as well as 2) assessing whether minority individuals are less likely to participate in a research study, or utilize the offered interventions versus their majority counterparts in the Healthy Body Image Program (HBI), a study of an online, guided self-help, ED intervention vs. referral to in-person care among college …

Evaluation Of The New Onset Diabetic Education Program For Navajo Adults, Denise S. Bartley

Nursing ETDs

The prevalence of diabetes mellitus (DM) is higher in American Indians/Alaska Natives (AI/AN) than in any other racial or ethnic group in the United States (U.S. Department of Health and Human Services [USDHHS] Centers for Disease Control and Prevention [CDC], 2018). In response to this escalating health issue, the U.S. government funded a number of DM education and treatment programs focusing on AI/AN populations. The purpose of this study was to evaluate the New Onset Diabetes Education Program (NODEP) based at Northern Navajo Medical Center (NNMC) in Shiprock, N.M.

The Navajo philosophy of learning was used as a guiding framework. …

The Effects Of Psychotropic Medications On Developing Brains, Abass Jafuneh

Nursing Capstones

No abstract provided.

Reducing Polypharmacy, Gladys A. Ndege

Nursing Capstones

No abstract provided.

Acquired Bracket Pellicle Modulation Via Exposure To Histatin 3, Niklas W. Neilson

Electronic Thesis and Dissertation Repository

Objectives: To investigate the effect of histatin 3 on the protein pellicle formation on the orthodontic bracket surface.

Methods: Our study consisted of 4 sample groups. A sample of human parotid saliva without histatin functioned as a control group. Other groups were immersed with or without histatin 3 and human parotid saliva. Each group was incubated for 2 hours in their respective substrate at 37°C. The acquired pellicle from each group was harvested, then analyzed with SDS-PAGE and LC-ESI-MS/MS.

Results: Thirty-nine proteins were identified in the control group, 18 were identified in group 2, and 21 were identified in group …

Identifying And Targeting Cancer Stem Cells In Colorectal Cancer, Amber Harnett

Electronic Thesis and Dissertation Repository

The cancer stem cell hypothesis posits that cancer stem cells (CSCs) are the driving force behind tumour progression and metastasis, making them ideal therapeutic targets. Previous research identified Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a marker of CSCs in colorectal cancer (CRC). However, it is not known whether more than one CSC population exists in CRC. Identifying and targeting CSCs in CRC is important for effective treatment of cancer patients. Here, I show that Keratin-19 (K19) labels intestinal CSCs in mouse tumours that recapitulate the early stages of CRC. Moreover, selective ablation of Lgr5 has no effect on tumour …

Effect Of Strong Electrolyte Containing Gelling Aids On The Sol-Gel Transition Temperature Of Hypromellose 2910, Elnaz Sadeghi

Biomedical Engineering ETDs

Hypromellose, or hydroxypropyl methylcellulose (HPMC) - has been widely used for biomedical and pharmaceutical applications due to its advantages, including that it is modifiable in terms of viscosity, and it has the ability to form thermally reversible hydrogels. The thermal gelation temperature (T_Gel) of a given HPMC solution strongly depends on its characteristic grade and the solution concentration. Applying certain additives can modify the T_Gel even further; depending on their nature and concentration. With the addition of said additives, a lower or higher T_Gel can be obtained. For example, the addition of sodium chloride (NaCl) reduces …

The Effects Of Inhibiting Pi3k On Tumor Suppressor Gene P53 And Cell Proliferation, Kelsi Peters

Undergraduate Theses and Capstone Projects

When the cell surface molecule, Human EGF Receptor (HER2), is overexpressed, the cell can become cancerous. MDA-MB-453 is an established breast cancer cell line made cancerous by HER2 overexpression. This mutation that causes HER2 overexpression affects the cell signaling pathway of phosphoinositide 3-kinase (PI₃K), Akt, MDM2, and p53. We predicted that PI₃K would be inhibited with the compound, LY294002, sending signals for Akt and MDM2 to be deactivated in MDA-MB-453 cells. Deactivated MDM2 signals for p53 to be activated. P53 is a tumor suppressor protein that exists in low quantities in normal cells, but when damage …

Impact Of Technology On Improving Hiv And Tuberculosis Health Outcomes Among African Countries, Sunny Ibeneme

Dissertations & Theses (Open Access)

This study used health analytics approach to evaluate the association between population health outcomes and Information and Communication Technology (ICT) infrastructures at a country level. This study used aggregate data obtained from the World Bank database, and the International Telecommunication Union (ITU) database for 53 African countries for the periods 2000 to 2016, and quantitatively explored the impact of ICT infrastructures’ diffusion on population health outcomes.

ICT data was obtained from the ITU database. Similarly, population health attributes were retrieved from the World Bank database. ICT infrastructure variables used in this study include: internet access, mobile phone use, and fixed …

The Role Of Interest Groups In Shaping U.S. Governmental Responses To Military Sexual Trauma, Patricia Ann Harnois-Church

Nursing ETDs

Military sexual trauma (MST) is a significant problem in U.S. military service branches, service academies, and National Guard units, with both immediate and longer term traumatic effects on survivors who are disproportionately female. MST includes sexual harassment or assault during military service and the ensuing consequences for physical health and psychosocial well-being of service members and veterans. The Department of Defense is committed to reducing the incidence of sexual assault and harassment among service members, encouraging victims to report, and mitigating the impact of MST. However, the estimated prevalence of sexual assault among active duty service members remains unacceptably high, …

Treatment Challenges Of Delusional Disorders, Amanda Mikhaeil

Nursing Capstones

No abstract provided.

Unlocking The Mysteries Of Weed And Mexico, Eddy Martinez

Capstones

An American biotech firm named Phylos Bioscience is interested in entering the Mexican marijuana market once it legalizes. Before it can do that, it must deal with the Mexican government and a conservative society.

https://eddymartinezcunyedu.atavist.com/figuring-out-the-mysteries-of-weed-and-mexico

Addicted To The Answer, Charumathi Raman

Capstones

Hypochondria, which is now broadly known as health anxiety, is the fear of a serious illness that continues despite evidence to the contrary from laboratory tests and the reassurance of physicians. In the past people with this disorder would go from doctor to doctor seeking an answer, but now many people rely solely upon online information.

For people with health anxiety, the Internet provides a lot of fodder. Researchers have recently coined the term "cyberchondria" to describe the phenomenon of increased health anxiety due to online health searches.

Entering questions like “Who started World War Two?” or “Who was the …

Surviving A Death Sentence, Amy K. Mackinnon

Capstones

Diagnosed with HIV at the peak of the AIDS epidemic, Sean McKenna had planned to die. Now, decades after life-saving drugs were first released, he and other long-term survivors are still figuring out how to live.
https://amykmackinnon.wordpress.com/capstone/

Women Are Being Cut During Childbirth Without Need Or Consent, Molly Cora Enking

Capstones

An episiotomy, a surgical cut used to enlarge the vaginal opening during childbirth, can be extremely painful, hard to recover from and can increase the risk of severe complications. In 2018, episiotomies are rarely necessary, but at some U.S. hospitals they happen much more than they should. And in the course reporting this story, New York City News Service found that it is common for doctors to cut women without the mother’s consent.

https://medium.com/@mollyenking/women-are-being-cut-during-childbirth-without-need-or-consent-7677de7eddae

Burden Of Proof: Insurance Companies Are Refusing To Pay For Mental Healthcare And Regulators Are Letting Them. Patients Are Left To Fend For Themselves., Graison Dangor

Capstones

When their mental health claims are denied, patients who are supposed to be protected by state and federal law have a choice: Don’t get care or pay for the care themselves, then fight to get paid back.

Link to capstone: https://graisondangor.github.io/mental-healthcare-equality/

The Invisible Brain Injury Crisis, Michael E. Rosenthal

Capstones

According to the Center for Disease Control and Prevention’s 2013 data, over 282,000 hospitalizations and 2.5 million emergency department visits were at least in part attributable to TBI. In the same year, about 56,000 people died.

Emergency departments in 2012 treated about 329,290 kids under 20 for TBI following an injury taking place during physical activity.

This project explores the rise in traumatic brain injuries and examines the difficult path that some of the survivors have to go through during recovery. By telling the story through my own personal experiences, I guide the reader through what the initial trauma and …

The Effectiveness Of Bispectral Index Monitoring On Intraoperative Awareness In Adult Surgical Patients Undergoing General Anesthesia, Eugene D. Lee

Master's Theses, Dissertations, Graduate Research and Major Papers Overview

Intraoperative awareness (IA), or the unexpected and explicit recall by patients of events that occurred intraoperatively, is a rare but serious event. Incidences of IA have been associated with extreme anxiety, physiologic stress, and the development of post-traumatic stress disorder. Anesthesia has debated the efficacy of brain monitoring devices, such as the Bispectral (BIS) index monitor, to reduce the incidence of IA. By analyzing EEG waves, these monitors can be used to alert the anesthesia provider when the patient may not be sufficiently anesthetized. An integrative review was conducted to evaluate the current evidence on the use of BIS monitoring …

Psychostimulants And Psychosis, Cherri L. Runde

Nursing Capstones

No abstract provided.

Synthetic Cannabinoid-Induced Psychosis, Kenna Kennedy

Nursing Capstones

No abstract provided.

Neural And Behavioral Associations Of Drinking And Empathic Processing, Charles Samuel Henry Robinson

Psychology ETDs

Alcohol Use Disorder (AUD) is a major health problem, yet most individuals with AUD do not perceive a need for formal treatment and do not receive treatment. The lack of treatment seeking among individuals with AUD may suggest a lack of self-awareness and insight into the seriousness of AUD related problems. Moreover, individuals who have lost or are at risk of losing major relationships are especially likely to perceive the need for help. Thus, it may be the case that awareness of the influence of one’s drinking on social relationships and the feelings of others (i.e., empathy) could improve treatment …

Design, Synthesis, And Evaluation Of C5 Substituted Carbapenem Antibiotics To Counter Resistant Pathogens, Noora Mohammed S.A Al-Kharji

Chemistry Theses and Dissertations

The 21st century has seen a dramatic acceleration in the evolution of bacterial resistance. Many classes of commercial antibiotics, including most current commercial β-lactams, were structurally optimized to counter 20th century pathogens. The carbapenems represent the most potent and broadest spectrum of the β-lactams, representing crucial last line agents to treat lifethreatening infections. While the 21st century has seen the appearance of carbapenem-resistant strains, the basic substitution pattern of commercial carbapenem antibiotics has remained constant, other than minor modifications at the C2 position. This research will investigate whether substitution at an atypical carbapenem position, the C5 position, can improve the …

Songbook And Activities: Popular Black Music Popular Songs From The 70’S To Present Day, Akeira Hill

Music Therapy Theses

Songbook and Activities: Popular Black music Popular Songs from the 70’s to present day

The Relationship Of Force-Time Variables Between The Loaded Squat Jump And The Midthigh Block Clean Pull, Hannah Marie Macke

Theses and Dissertations from 2018

Loaded squat jumps and midthigh block clean pulls are exercises that can be used in a strength and conditioning program to increase lower-body power. Lower-body power is critical in jumping, sprinting, and other sport specific movements. Intensities of 45-pound barbell, 20%, 40%, and 60% of a high-force, low-velocity movement were used to assess the force-time variables of the loaded squat jump and midthigh block clean pull. The current study compared peak power output as well as peak barbell velocity to find which exercise and intensity combination would be most beneficial for an athlete to increase lower-body power. A linear position …

An Interdisciplinary Code Sepsis Team To Improve Sepsis Bundle Compliance In The Emergency Department, Jill M. Delawder

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Purpose: Sepsis is one of the leading causes of mortality with over 700,000 hospitalizations and 200,000 deaths annually. Various tools exist to aid in the early identification and treatment of sepsis including electronic alert systems, standardized order sets, nurse-initiated protocols and specialty trained teams. Despite available guidelines, mortality rates for severe sepsis and septic shock are near 50%.

Methods: The aims of this rapid cycle quality improvement project were 1) to develop and implement an interdisciplinary team to address early implementation of evidence-based sepsis bundles in the emergency department and 2) to compare sepsis bundle compliance three months pre-and three …

Use Of Telemedicine To Improve Cpap Non-Adherence In Patients With Obstructive Sleep Apnea, A Pilot Study, Kristin L. Hanger

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Abstract

The aim of this project is to improve continuous positive airway pressure (CPAP) non-adherence in patients newly diagnosed with obstructive sleep apnea. Obstructive sleep apnea (OSA) is caused by recurrent collapse of the upper airway during sleep. Untreated, OSA is associated with co-morbidity and decreased quality of life. The standard for OSA treatment is CPAP. Adherence to CPAP is not optimal. Applying telemedicine technology to monitor adherence of CPAP treatment, allows for early intervention. Prior research has shown mixed results with use of telemedicine on non-adherence rates.

This is a pilot study using telemedicine to monitor adherence data to …

Video-Based Diabetes Education For A Culturally Diverse Population, Heather Harris

Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects

Immigrants and refugees represent an underserved population in need of quality, accessible, and culturally appropriate healthcare and education. Diabetes is a chronic condition frequently seen in this population. The author utilized the Wagner Chronic Care Model (CCM) as a theoretical framework for planning diabetes education delivery in this diverse population. Studies report significant health disparities in diabetes care and subsequent poor diabetes quality indicators in refugees and immigrants. Research has found that culturally sensitive diabetes education can improve diabetes outcomes in ethnically diverse populations. The author implemented a translational project to develop and evaluate a video-based diabetes health education intervention …

An Analysis Of Interprofessional Rounds Effect On Readmission Rates And Patient Satisfaction, Cynthia Atkinson

Doctor of Nursing Practice (DNP) Final Clinical Projects, 2016-2019

Evidence supports an interprofessional approach to patient care reduces readmissions, mortality, costs, and length of stay while simultaneously increasing communication, collaboration, and satisfaction of care providers and patients (Vazirani, S., et al, 2005). The health care team in an acute care setting, especially direct patient care providers such as nurses and ancillary disciplines must assess the discharge needs of patients from admission to the hospital until discharge disposition (Zakzesky, Klink, McAndrew, Schroeter, & Johnson, 2015). The purpose of this study was to determine if interprofessional rounds improved patient satisfaction and reduced readmission rates. The interprofessional team consisted of the hospitalists, …

Cocoa, Postprandial Lipoproteins, And Inflammation In Type 2 Diabetes: A Secondary Data Analysis, Rickelle Tallent

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Type 2 Diabetes (T2D) is associated with dyslipidemia and chronic low-grade inflammation, which greatly increases the risk of cardiovascular disease (CVD) in this population. Hyperlipidemia and inflammation in the postprandial state substantially contribute to atherosclerosis development and CVD risk, and have shown to be exacerbated by high-fat meals. Dietary cocoa is a rich source of flavanols that is associated with favorable effects on cardiovascular health, such as improvements in the lipid profile and chronic inflammation, in non-diabetic adults.

Objective: To conduct a secondary data analysis using unpublished data from a previously conducted clinical study to determine whether acute cocoa …

Sequence Analysis Methods For The Design Of Cancer Vaccines That Target Tumor-Specific Mutant Antigens (Neoantigens), Jasreet Hundal

Arts & Sciences Electronic Theses and Dissertations

The human adaptive immune system is programmed to distinguish between self and non-self proteins and if trained to recognize markers unique to a cancer, it may be possible to stimulate the selective destruction of cancer cells. Therapeutic cancer vaccines aim to boost the immune system by selectively increasing the population of T cells specifically targeted to the tumor-unique antigens, thereby initiating cancer cell death.. In the past, this approach has primarily focused on targeted selection of ‘shared’ tumor antigens, found across many patients. The advent of massively parallel sequencing and specialized analytical approaches has enabled more efficient characterization of tumor-specific …