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Full-Text Articles in Medicine and Health Sciences
Tumor Immunity Following Adenovirus Mediated Herpes Simplex Thymidine Kinase Gene Transfer To Experimental Rat Gliomas, Maulik Raj Shah
Tumor Immunity Following Adenovirus Mediated Herpes Simplex Thymidine Kinase Gene Transfer To Experimental Rat Gliomas, Maulik Raj Shah
Theses and Dissertations
Previous studies have determined adenovirus mediated herpes simplex thymidine kinase gene transfer (AV-TK) to be effective for the treatment of experimental gliomas. In this study we report three distinct phenomenon. First, animals with complete regression of subcutaneous tumors upon intratumoral injections of AV-TK with concomitant Ganciclovir® (GCV) administration developed tumor immunity. These animals had the ability to reject a subsequent inoculum of lethal doses of tumor cells. This tumor immunity was long standing and protective as far as 6 months from the time of initial tumor ablation. Of interest, adoptive transfer of splenocytes from AV-TK treated-tumor ablated animals to naive …
Comparison Of Epidural And Intravenous Fentanyl Patient-Controlled Analgesia After Cesarean Section Under Epidural Anesthesia With Chloroprocaine, Kim M. Larsen
Theses and Dissertations
This study compared two methods of postcesarean fentanyl patient- controlled analgesia (PCA). Fentanyl was administered intravenously (PCAI) or epidurally (PCAE) following cesarean section under epidural chloroprocaine anesthesia. Twenty-one ASA I and II parturients were randomly assigned to receive fentanyl PCAI (n = 9) or PCA (n = 12). At surgical completion fentanyl 1.0 mcg/kg was given and the PCA initiated with a dose of 30 mcg, a lockout interval of 10 minutes, a maximum dose of 180 mcg/hr, and no basal rate. Data were collected over 24 hours including visual analog scale (VAS) pain scores, …