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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Modeling The Oxidative Metabolic Breakdown Of Ethanol And Its Effects On The Cardiovascular System, Jessica F. Farfan, Allan Knox, Grady Hanrahan
Modeling The Oxidative Metabolic Breakdown Of Ethanol And Its Effects On The Cardiovascular System, Jessica F. Farfan, Allan Knox, Grady Hanrahan
International Journal of Exercise Science: Conference Proceedings
Chronic ethanol consumption contributes to the global prevalence’s of cardiovascular disease by mechanisms involving an inflammatory response and consequent lipid peroxidation. Cytochrome p450 is a part of the microsomal ethanol oxidizing system (MEOS) and can utilize iron complexes and the reductant NADPH to catalyze the breakdown of acute/chronic ethanol consumption. However, efficacy of MEOS to prevent cardiovascular burden induced by ethanol consumption is not clear. PURPOSE: To demonstrate the response of the cardiovascular system in response to the oxidative metabolic breakdown of ethanol via MEOS. METHODS: An extensive literature search provided data to develop a mechanistic model of the metabolism …
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
Removal Of Mimosine From Leucaena Leucocephala (Lam.) De Wit Seeds To Increase Their Benefits As Nutraceuticals, Sri Wardatun, Yahdiana Harahap, Abdul Mun'im, Fadlina Chany Saputri Dr., Noorwati Sutandyo
Removal Of Mimosine From Leucaena Leucocephala (Lam.) De Wit Seeds To Increase Their Benefits As Nutraceuticals, Sri Wardatun, Yahdiana Harahap, Abdul Mun'im, Fadlina Chany Saputri Dr., Noorwati Sutandyo
Pharmaceutical Sciences and Research
The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value. The extraction yields show the number of compounds that have been extracted by solvent. However, Leucaena leucocephala (Lam.) de Wit seeds also contain mimosine, which can cause hair loss. The present study investigated the process of removing mimosine from the seeds. Three treatments were applied to these seeds: treatment without soaking, soaking with distilled water for 24 hours, and splitting the seeds in half and then soaking …
Effectiveness Of Embalming Solutions With Partial Replacement Of Formaldehyde And Phenol With Ethanol And Sodium Chloride On Mice Over 18 Months, Kriengyot Sajjacharoenpong, Pawana Chuesiri
Effectiveness Of Embalming Solutions With Partial Replacement Of Formaldehyde And Phenol With Ethanol And Sodium Chloride On Mice Over 18 Months, Kriengyot Sajjacharoenpong, Pawana Chuesiri
The Thai Journal of Veterinary Medicine
Animal preservation for anatomy teaching has been required to replace formaldehyde and phenolwhich represent a health hazard to humans. A comparative study of embalming solutions with partial replacement of formaldehyde and phenol with sodium chloride and ethanol was evaluated in mouse cadavers over an 18-month period. Twelve adult mouse carcasses were divided into six groups of two mice each. After openingthe mouse’s skin,the internal organswere removed and preserved with the remaining cadavers by freezing (Group I, control group) or in the respective embalming solution (Groups II to VI) and examined after 3, 6, 12 and 18 months. For the embalming …
Our Energy Future, Fall/Winter 2007, Issue 15
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Background/aim: The effects of chronic ethanol consumption on male sexual function are debateable, and its effects on the Rho/ Rho-kinase pathway are unknown. Therefore, we investigated smooth muscle reactivity and Rho/Rho-kinase signalling in the corpus cavernosum of ethanol-fed mice. Materials and methods: Ethanol was added to drinking water at 5% concentration in the first 2 days with 5% increment every subsequent 2 days, up to a final concentration of 20% for 45 days. Corpora cavernosa were isolated and a cumulative dose-response curve to phenylephrine was obtained. Acetylcholine (10-6 M), electrical field stimulation (EFS, 40 V, 8-16 Hz) and Y-27632 (10-6-10-5 …
Moderate Ethanol Consumption Results In Cognitive Protection From Alzheimer’S Disease, Dementia, And Related Cognitive Decline: A Critical Review, Sean P. Coffinger
Moderate Ethanol Consumption Results In Cognitive Protection From Alzheimer’S Disease, Dementia, And Related Cognitive Decline: A Critical Review, Sean P. Coffinger
Butler Journal of Undergraduate Research
Moderate ethanol preconditioning, a result of prolonged moderate alcohol intake, serves as a protective process by staving off cognitive decline while providing neuronal protection through several mechanisms. These individual mechanisms are relatively well known, however a comprehensive and integrated conversation of ethanol’s protective tendencies is lacking from literature and the field of neuroscience. First, a review of the leading theories behind moderate ethanol preconditioning’s biological and cognitive benefits is presented, including overviews of neuroprotective, antioxidant, and neurotropic mechanisms responsible for neurological benefit. Secondly, an integrative model is presented, incorporating all research into a novel collaborative model. An additional discussion regarding …
Effects Of Some Of The Regional Turkish Fermented Foods And Medications On Respiratory Alcohol Levels, Cem Uysal, Mustafa Karapi̇rli̇, Mehmet Aki̇f İnanici
Effects Of Some Of The Regional Turkish Fermented Foods And Medications On Respiratory Alcohol Levels, Cem Uysal, Mustafa Karapi̇rli̇, Mehmet Aki̇f İnanici
Turkish Journal of Medical Sciences
Alcohols are used in many areas like medicine and industry. They may be naturally found in some fruits and vegetables secondary to fermentation. According to the traffic law in Turkey, professional drivers are prohibited from driving while they are under the influence of alcohol; nonprofessional drivers are allowed to drive vehicles with a blood alcohol level of up to 50 mg/dL. The aim of this research is to determine whether or not consumed medicine or fermented, nonalcoholic beverages cause false positive results in breathalyzer tests. Materials and methods: In this research, we used nonalcoholic fermented foods and 6 medicines. After …
Effect Of Oocyte Quality And Activation Protocols On Bovine Embryo Development Following Intracytoplasmic Sperm Injection, Ömer Korkmaz, Şükrü Küplülü, Yüksel Ağca, İbrahi̇m Mert Polat
Effect Of Oocyte Quality And Activation Protocols On Bovine Embryo Development Following Intracytoplasmic Sperm Injection, Ömer Korkmaz, Şükrü Küplülü, Yüksel Ağca, İbrahi̇m Mert Polat
Turkish Journal of Veterinary & Animal Sciences
The purpose of this study was to investigate the effects of oocyte quality and activation protocols on the in vitro developmental competence of bovine embryos after intracytoplasmic sperm injection (ICSI). Bovine oocytes were grouped as being of excellent, good, and poor quality. All of the oocytes were activated using a calcium ionophore only, ethanol only, and 6-dimethylaminopurine (6-DMAP) following calcium ionophore. For the excellent quality oocytes, cleavage rates after ICSI were 70% in the Ca ionophore + 6-DMAP activation group, 47% in the ethanol activation group, 41.82% in the Ca ionophore group, and 30% in the nontreated control group. Cleavage …
Contribution Of Phospholipase C And Protein Kinase C But Not Endothelin-Converting Enzyme To Contractile Responses Of Ethanol, Naci̇ye Döndaş, Hali̇l Mahi̇r Kaplan, Derya Kaya, Erği̇n Şi̇ngi̇ri̇k
Contribution Of Phospholipase C And Protein Kinase C But Not Endothelin-Converting Enzyme To Contractile Responses Of Ethanol, Naci̇ye Döndaş, Hali̇l Mahi̇r Kaplan, Derya Kaya, Erği̇n Şi̇ngi̇ri̇k
Turkish Journal of Medical Sciences
Aim: To evaluate the possible roles of phospholipase C, protein kinase C, and endothelin-converting enzyme on contractions induced by ethanol (164 mM) in isolated gastric fundal strips of mice. Materials and methods: After the mice were killed, the stomach of each was removed and longitudinal muscle strips were prepared from the gastric fundus. The strips were mounted in organ baths and their responses were recorded isometrically. Ethanol (164 mM) was added to the organ baths and a steady-state contraction was obtained. After the first ethanol response was recorded, the preparations were incubated separately with lidocaine (1-100 µM), neomycin (10-500 µM), …
Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong
Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong
The Thai Journal of Veterinary Medicine
The aim of this study was to compare the efficacy of ethanol and acetone in dehydration of canine bodysheets before preservation in resin for a 16-week period. A 10-kg male dog which died of the respiratory failure waspreserved in 10% formalin via common carotid artery at room temperature for 7 days prior to being kept in a freezerat -250C for 7 days. The body of the dog was cut into 2.5-cm-thick sheets with a band saw. The body sheets wereseparately dehydrated for 3 days with either acetone or ethanol. In this study, the color of muscles and fat fromacetone-dehydrated sheets …
Effect Of Pre-Evisceration, Skin-On Carcass Decontamination Sanitation Strategies For Reducing Bacterial Contamination Of Cattle During Skinning, Mehmet Çalicioğlu, Dennis R. Buege, John B. Luchansky
Effect Of Pre-Evisceration, Skin-On Carcass Decontamination Sanitation Strategies For Reducing Bacterial Contamination Of Cattle During Skinning, Mehmet Çalicioğlu, Dennis R. Buege, John B. Luchansky
Turkish Journal of Veterinary & Animal Sciences
The effectiveness of pre-evisceration, skin-on carcass sanitation on reducing bacterial contamination of beef carcasses was tested using 3 cattle per treatment and 3 cattle as controls at each of 3 abattoirs in southern Wisconsin. The sanitation procedure included stunning, bleeding, tying off the esophagus, sealing the anus, and then sanitizing the hide with: i) 20% trisodium phosphate, ii) 200 ppm iodophor, iii) 75% ethanol, or iv) hot water (ca. 80 °C). Two sets of combined sponge samples (3 × 100 cm^2) were taken from the hide before and after the sanitation step, as well as from the carcass after the …
E-85 Vs. Regular Gasoline: Effects On Engine Performance, Fuel Efficiency, And Exhaust Emissions, Jordan W. Steinhaus, Donald M. Johnson, George W. Wardlow
E-85 Vs. Regular Gasoline: Effects On Engine Performance, Fuel Efficiency, And Exhaust Emissions, Jordan W. Steinhaus, Donald M. Johnson, George W. Wardlow
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
This study compared the performance, fuel efficiency, and exhaust emissions of a 2.61 kW engine fueled with regular unleaded gasoline (87 octane) and an 85% ethanol blend (E85) under two load conditions. Four 1-h tests were conducted with each fuel at both governor’s maximum (3400 rpm) and peak torque (2800 rpm) conditions for a total of 16 tests. At governor’s maximum engine speed, there were no significant differences (p>0.05) between fuels for engine torque, power, specific carbon dioxide (sCO2 ), specific carbon monoxide (sCO), specific hydrocarbons (sHC), or specific oxides of nitrogen (sNOX) emissions. However, there was a significant …
The Treatment Of Experimental Acute Ethylene Glycol (Antifreeze) Toxication Using 4-Methyl Pyrazol And Ethanol In Dogs, Vehbi̇ Güneş, Çeti̇nkaya Şendi̇l
The Treatment Of Experimental Acute Ethylene Glycol (Antifreeze) Toxication Using 4-Methyl Pyrazol And Ethanol In Dogs, Vehbi̇ Güneş, Çeti̇nkaya Şendi̇l
Turkish Journal of Veterinary & Animal Sciences
The effects of ethanol and 4-methyl pyrazole were investigated in the treatment of 30 dogs toxicated with antifreeze (AF). The AF toxication produced significant increases in blood urea, creatinin and potassium and a decrease in blood calcium levels. Calcium-oxalate monohydrate, which is pathognomic for AF toxication, was consistently seen in urine sediment. Ethanol was rarely effective on the multisystemic effects that occurred in dogs or ADH inhibition. CNS findings were also observed after ethanol administration. The results indicated that 4-MP treatment provided earlier and safer healing than ethanol. It was deduced that 4-MP + NaHCO_3 was more effective than ethanol …
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Turkish Journal of Medical Sciences
The aim of this study was to determine the histological changes of the thoracic aorta in rats fed on alcohol for a period of 24 weeks. Twenty male Wistar rats were divided into two groups. The ethanol group (n=10) was fed on a modified liquid diet (MLD) containing 7.2% ethanol for 24 weeks. The control group (n=10) was fed on MLD without ethanol throughout the experiment. At the end of the 24 weeks, the carotid arteries of the rats were cannulated and their blood pressures were measured. Ethanol levels measured by using the NAD+/NADH enzyme-spectrophotometric method. Rats were killed by …
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
Turkish Journal of Veterinary & Animal Sciences
In this study, some blood, liver and kidney parameters of rats which were given alcohol orally were investigated at the end of 1st, 7th, 14th and 21st days. Forty male Wistar Albino rats (mean 196 g), 20 wk of age, were used as materials. Serum AST and \gamma-GT activities at the end of 1st day were significantly different between control and experimental groups from 40 rats studied. At the end of 7th, 14th and 21st days, the difference between two groups for AST and \gamma-GT activities in serum and liver were significant (p