Medicine and Health Sciences Commons^™

Diagnosis And Excision Of A Solitary Trichoepithelioma, Leonid Skorin Jr., Do, Od, Ms

Optometric Clinical Practice

Abstract

Background: Solitary trichoepithelioma is a rare benign tumor of hair follicle origin. Although trichoepithelioma has a predilection for the face and neck, it is not usually found on the eyelids. It has similar clinicopathological features to basal cell carcinoma. Surgical excision and histopathologic analysis is helpful for correct diagnosis.

Case Report: A 59-year-old Caucasian female presented with a raised, reddish oval mass on the right lower eyelid. The mass had telangiectatic blood vessels on its surface, was non-pigmented and slightly umbilicated. It was in close approximation of the eyelid margin causing distortion and poor apposition of the lid to …

Odor Detection Of Cancer Cell Metabolites By Scent-Detection Dogs, Geontae Park, Dongwook Kim, Seongsoo Jeong, Dongsun Park, Gonhyung Kim

The Thai Journal of Veterinary Medicine

Dogs have a superior olfactory system; thus, they have been trained and used to detect various nonbiological and biological scents. In addition, many studies have recently reported dogs’ ability to detect the odor of certain cancers or cancer cells. A previous study documented that a dog trained to detect a certain malignant cancer cell could also detect another, unfamiliar malignant cancer cell well, implying that these two cancer cells share a certain specific odor. Thus, given the hypothesis that malignant cancer cells of different origins may contain a common cancer-specific odor, the purpose of the present study was to evaluate …

The Hispanic Paradox In Non-Small Cell Lung Cancer, Rohit Kumar, Franklin Castillero, Shruti Bhandari, Sindhu Malapati, Goetz Kloecker

Hematology/Oncology and Stem Cell Therapy

Objective/Background: According to the U.S. Census Bureau, 18% of the total population in the United States identified themselves as Hispanic in 2016 making it the largest minority group. This study aimed to evaluate the effect of Hispanic ethnicity on the overall survival of patients with non-small cell lung cancer (NSCLC) using a large national cancer database. Methods: We used the National Cancer Database to identify patients diagnosed with NSCLC between 2010 and 2015. The two comparative groups for this study were non-Hispanic Whites (NHWs) and Hispanics. The primary outcome was overall survival. Results: Of the 555,475 patients included in the …

Patterns Of Postmastectomy Radiation Therapy In Clinically Node-Positive Breast Cancerpatients With Pathologically Negative Lymph Nodes After Neoadjuvant Chemotherapy, Mutlay Sayan, Irina Vergalasova, Mridula George, Maria Kowzun, Lindsay Potdevin, Shicha Kumar, Bruce Haffty, Nisha Ohri

Turkish Journal of Medical Sciences

Background/aim: To analyze postmastectomy radiation therapy (PMRT) utilization and its association with overall survival (OS) in patients presenting with node-positive breast cancer who are pathologically node-negative (ypN0) after neoadjuvant chemotherapy (NAC). Materials and methods: Using the National Cancer Data Base (NCDB), we identified patients diagnosed between 2004 and 2013 with clinical T1-4 node-positive nonmetastatic breast cancer who received NAC and underwent mastectomy with pathologically negative lymph node sampling. Multivariable regression models identified factors associated with PMRT use. The Cox proportional hazards model was used to evaluate predictors of mortality. Results: The study included 8766 clinically node-positive patients who met the …

Value Of L-Alanyl-L-Glutamine Parenteral Formula In Patients With Head And Neck Cancer Receiving Radiotherapy, Eman A. Tawfeek, Enas A. Elkhouly, Mohamed A. Shehata, Mohammed A. Shalaby, Shaimaa S. Soliman, Suzy F. Gohar

Menoufia Medical Journal

Objective The aim was to determine the effect of administration of parenteral l-alanyl-l-glutamine-containing formula on occurrence of treatment-related malnutrition and acute radiotherapy (RT)-related toxicities in patients with head and neck cancer. Background Studies have shown that glutamine-containing nutritional therapy can improve the nutritional status of adult patients with cancer. Patients and methods A total of 40 patients with head and neck carcinoma were randomized to receive either parenteral l-alanyl-l-glutamine-containing formula (0.4 mg/kg) during the first 2 weeks of RT (with or without chemotherapy) or placebo. Nutritional assessment was done for all patients at diagnosis and on weekly basis till end …

Carcinoma Renal Con Translocación Xp11.2 En Una Infante, Gloria Paredes-Guerra, Javier Larios-León, Carol Gonzales-Gonzales

Revista de la Facultad de Medicina Humana

El carcinoma de células renales con translocación (CRT) es un subtipo de carcinoma de células renales (CCR). El presente caso trata de una niña de 11 años con dolor en fosa ilíaca derecha de dos semanas de evolución. Se evidenció tumoración de 2,2 x 1,9 x 2,8 cm en el polo superior del riñón derecho, por ecografía. Luego, fue sometida a nefrectomía radical derecha y a disección ganglionar regional, tras lo cual se diagnosticó CRT subtipo Xp 11.2. Posteriormente, se inició tratamiento de primera línea con pazopanib y quimioterapia concomitante. Esta enfermedad es más frecuente entre los 10 y 15 …

Treatment Of Basal Cell Carcinoma With Vismodegib, Sunitha Johns, Katlyn Brown, Emily Loudermilk, Crystal Zheng, Anh Dao Le, Sophocles Chrissobolis

Pharmacy and Wellness Review

The most prevalent nonmelanoma skin cancers are basal cell carcinoma (BCC) and locally advanced basal cell carcinoma (aBCC). Current, effective first-line treatments for BCC aim to remove and destroy cancerous skin cells through excision surgery, Mohs surgery, radiation therapy and cryotherapy, while treatment of aBCC remains limited. An emerging treatment option for aBCC that promotes tumor size reduction is vismodegib, a pharmaceutical product approved in 2012 by the U.S. Food and Drug Administration (FDA). Vismodegib was approved for the treatment of aBCC, metastasized HCC (mBCC) or recurrent BCC after surgery as well as for use in adults who are not …

Programmed Death Pathway Inhibition: Emerging Therapeutic Options For Treatment Of Advanced Or Refractory Cancers, Katherine Elsass, Morgan Homan, Jana Randolph, Brendan Rasor, David Kinder

Pharmacy and Wellness Review

The programmed death-1 (PD-1) pathway has a significant role in the promotion of immune tolerance. The PD-1 receptor ligands are normally expressed on various inactive immune cells. When cancer cells express these ligands, they are able to interact with active T and B lymphocytes to induce this tolerance. Nivolumab and pembrolizumab are two recently approved agents that act to disrupt this binding and facilitate an immune response against cancer cells. Numerous trials, including KEYNOTE-002 and CheckMate 063, have demonstrated the superior safety and efficacy of these drugs in patients with advanced or refractory cancers. Initially approved for the treatment of …

Sebaceous Carcinoma Of Parotid With Cervical Lymph Node Metastasis: Case Report And Review Of Literature, Ramaswamy Balakrishnan, Agarwal Ashish C, Venkitachalam Shruti

Manipal Journal of Medical Sciences

We report the case of a 72-year-old woman who was presented to us with a right pre- and infra-auricular and neck swelling. On evaluation, she was diagnosed to have parotid malignancy with cervical lymph node metastasis. The mass was surgically excised, and a histopathological report of sebaceous carcinoma was obtained. She had a past history of right eye malignancy. A review of literature on sebaceous carcinoma was carried out. This article is about a rare tumour at an atypical site

A Pilot Study Of Circulating Tumor Cells In Stage Iv Non-Small Cell Lung Carcinoma, Max Haid, Edward Chesna, Mary Theodoroff, Debra K. Spaeth, Cheruppolil R. Santhosh-Kumar, Zahid N. Dar

Journal of Patient-Centered Research and Reviews

Purpose

Measurement of the number of circulating tumor cells (CTCs) in the bloodstream has been shown to have prognostic significance in treating breast carcinoma. This pilot study was formulated to determine if stage IV non-small cell lung carcinomas similarly shed malignant cells into the circulation and if their presence has prognostic significance.

Methods

Patients with stage IV non-small cell lung carcinomas were tested once for CTCs in 7.5 ml of their blood prior to receiving any treatments. A proprietary blood collection kit produced by Veridex LLC (Raritan, NJ), which manufactures the instrument that performs the immunomagnetic CELLSEARCH^® CTC assay, …

Evaluation Of Β-Catenin Expression In Muscle-Invasive Urothelial Bladder Carcinoma, Eid Abdel-Rasoul Elsherif, Fatma Ahmed Elserafy, Marwa Mohamed Dawood, Mohamed Sayed El Gharabawy, Noha Mohamed Nor-Eldin-Elkady, Tarek Mohamed Abdel Elbaky

Menoufia Medical Journal

Objectives This study aimed at evaluation of the expression of β-catenin in muscle-invasive urothelial bladder carcinoma and its correlation with other clinicopathological parameters of prognostic importance. Background β-Catenin is a protein that is encoded by the CTNNB1 gene that can function as an oncogene. Activation of the Wnt/β-catenin signaling pathway by aberrant accumulation of stabilized β-catenin contributes to the progression of several human cancers. Therefore, inhibition of the Wnt pathway may have a major therapeutic potential. Patients and methods This study was conducted as a retrospective study at Urology and Pathology Departments, Faculty of Medicine, Menoufia University, during the period …

Long-Term Results Of Pancreaticoduodenectomy And Endoscopic Resection In The Treatment Of Early Stage Carcinoma Of The Ampulla Of Vater: Case Series And Review Of The Literature, Abdulkadi̇r Dökmeci̇, Mustafa Yakut, Necati̇ Örmeci̇, Hasan Özkan, Gökhan Kabaçam

Turkish Journal of Medical Sciences

We retrospectively evaluated 6 cases to explore the role of curative pancreaticoduodenectomy and endoscopic resection of ampulla of Vater tumors. Six patients diagnosed with stage 1 ampullary tumors at Ankara University Hospital between January 1994 and September 2009 were analyzed retrospectively. Icterus was the cardinal symptom in all patients. The median time for the symptoms caused by the lesion of the papilla was 7 weeks in patients with carcinoma. The diameters of the visualized tumors were less than 20 mm. Diabetes mellitus was observed in 2 patients. When the patients were classified according to TNM staging, all patients were in …

Differentiating Renal Cell Carcinoma Clear Cell Subtype From Other Subtypes On Multiphasic Multidetector Computed Tomography, N Lertlarpwasin, K Sasiwimonphan, W. Kittikowit

Chulalongkorn Medical Journal

Background : Renal cell carcinomas (RCC) represent about 1 - 3% of all visceral cancers and 85% of renal cancers in adults. The tumors occur most often in old age, usually in sixth and seventh decades of life, and more predominantly in males. There are different prognosis between each subtype of RCC and different targeted therapy of choice for clear cell and non-clear cell subtypes of RCC. Subtype differentiation of RCC is quite important for guided treatments and predicted prognosis. (according to the NCCN's Clinical Practice Guideline for Renal Cancer 2009). Objective : This study aims to differentiate clear cell …

Isolated Rupture Of Extrahepatic Bile Ductfollowing Blunt Abdominal Trauma, A. Mahayosnond, C. Sangthammarat, S. Roekwibunsi

Chulalongkorn Medical Journal

No abstract provided.

Systemic Lupus Erythematosus: How Does Itaffect Pregnancy Outcome?, B. Uerpairojkit, W. Tharamas, S. Tanawattanacharoen, S. Manotaya, Y. Tannirandorn, D. Charoenvidhya

Chulalongkorn Medical Journal

No abstract provided.

เมตาสแตติคคอริโอคาร์ซิโนมาของช่องปาก : รายงานผู้ป่วย, สุรศักดิ์ ชี้รัตน์

Chulalongkorn University Dental Journal

รายงานผู้ป่วยหนึ่งราย เป็นหญิงจีน อายุ 36 ปี มีก้อนเนื้องอกสีแดงจัด ลักษณะอ่อนนุ่ม เลือดออกง่าย งอกขึ้นมาจากแผลถอนฟันของเบ้ากระดูกรองรับฟันที่ไม่หายและเหงือกบริเวณ 22 วินิจฉัยทางคลินิกว่าเป็นมะเร็ง ลักษณะจุลพยาธิวิทยาของเนื้องอกนี้ ประกอบด้วยไซโตทรอโฟบลาสและซินไซติโอทรอโฟบลาสและพบบริเวณที่มีเลือดออกและเนื้อตายจากขาดเลือดอยู่ใต้เยื่อบุผิวช่องปาก ผลการวินิจฉัยทางจุลพยาธิวิทยาเป็น "เมตาสแตติคคอริโอคาร์ซิโนมาของเหงือกและกระดูกแม็กซิลลา บริเวณ 22"

Review Of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind The Cancer Scares, Sarah Redfield

RISK: Health, Safety & Environment (1990-2002)

Review of: Elizabeth M. Whelan, Toxic Terror: The Truth Behind the Cancer Scares (Prometheus Books 1993). Acknowledgements, appendix, figures, foreword by Norman F. Borlaug, index, notes tables. LC 92-34154; ISBN 0-87975-788-4. [476 pp. Cloth $26.95. 59 John Glenn Drive, Buffalo NY 14228-2197.]

Cancer Eye Of Cattle, M R. Gardiner, J. L. Anderson, D. E. Robertson

Journal of the Department of Agriculture, Western Australia, Series 4

Cancer of the eye and eyelids is mainly a disease of cattle, although it occasionally occurs in most species of animals and in man. It is the most common cancer in cattle, especially in certain breeds.