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A Brief Literature Review Of Low-Level Laser Therapy For Treating Amyotrophic Lateral Sclerosis And Confirmation Of Its Effectiveness, Sergey Vladimirovich Moskvin

BioMedicine

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a steadily progressive course due to the death of central and peripheral motor neurons responsible for voluntary movements. Low-level laser therapy (LLLT) is a treatment method unique in its universality and efficacy, particularly for neurodegenerative diseases.

Methods: In this review, we discuss the effect and application of LLLT in the treatment of ALS. A literature search for English and Russian publications for the keywords "Amyotrophic Lateral Sclerosis", "Low-Level Laser Therapy" was performed using PubMed, Scopus, Google Scholar, Web of Science and Russian Science Citation Index (RSCI) databases.

Results: The article …

Is Gut Microbiota Of Patients With Als Different From That Of Healthy Individuals?, Zeri̇n Özaydin Aksun, Seyda Erdoğan, Ayşe Kalkanci, Eli̇f Ayça Şahi̇n, Tuğba Çuhadar, H. Özden Şener

Turkish Journal of Medical Sciences

Background/aim: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Several studies shown that alterations of microbiota, increase the risk of neurodegenerative disorders. We aimed to reveal whether there is a difference in the gut microbiota of patients with ALS.Materials and methods: The participants are divided into three groups. Group 1 formed patients with ALS. Healthy family members living in the same house of the patients formed Group 2. Lastly, sex, age-matched healthy people were included in Group 3. Fecal samples were collected in 15 mL falcon tubes and stored at -80 °C. Genomic DNA isolation was performed on samples. …

Determining The Initial Content Validity Of The Clinical Competency Assessment Tool (Cat) For Occupational Therapists Treating Patients With Neurodegenerative Disease, Scott G. Rushanan, Dawn M. Nilsen, Lenin Grajo

The Open Journal of Occupational Therapy

The provision of occupational therapy (OT) interventions for people with neurodegenerative disorder (NDD) requires advanced clinical competency; therefore, a means to evaluate that competency is needed. The Clinical Competency Assessment Tool for Occupational Therapists Treating Patients with Neurodegenerative Disease (CAT) was recently developed as a self-report assessment that aims to identify gaps in clinical competence and measure outcomes of professional development programs specific to occupational therapists treating patients with NDD. The purpose of this study is to explore preliminary content validity of the CAT. Classical test theory was used to test for content validity. A panel of 10 expert occupational …

Amyotrophic Lateral Sclerosis Presenting As Chronic Cough, Marjorie Friedman, Md

The Medicine Forum

INTRODUCTION

Amyotrophic Lateral Sclerosis (ALS) is a debilitating, uniformly fatal disease. While it most commonly presents with limb weakness, patients may also present with neurocognitive, respiratory, or bulbar symptoms. Despite its poor prognosis, an early diagnosis can save patients from unnecessary and expensive testing, lead to interventions that improve quality of life, and give patients and family time for advanced planning.1 This case highlights an unusual presentation of ALS.

KEY POINTS

• Our patient presented with chronic cough and restrictive lung disease and after extensive workup was diagnosed with ALS.
• Bulbar and respiratory symptoms are uncommon initial presentations of ALS.
• Early …

Cross-Sectional Survey Of Relevant Literatures As To The Current Proposed Disease Mechanisms And Treatments Of Amyotrophic Lateral Sclerosis (Als), Zachary Sanford

Marshall Journal of Medicine

Amyotrophic Lateral Sclerosis (ALS), more commonly referred to as Lou Gehrig’s disease, is a progressively degenerative neuromuscular disorder affecting both the upper and lower motor neurons and preferentially affecting males in their forties to seventies. Although the pathology of ALS has been clearly elucidated elsewhere, the precise mechanisms by which the disease progresses and the means by which it is acquired are still poorly understood areas of medicine. Current genomic and proteomic studies in human and animal models have yielded exciting and promising new findings that may help elucidate this pathology. It is the purpose of this review article to …

Amyotrophic Lateral Sclerosis (Als) And Spinal Muscular Atrophy (Sma): A Genetic Linkage?, Michael Groden

The Science Journal of the Lander College of Arts and Sciences

Neurodegenerative motor neuron disorders (MNDs) have devastating effects. Spinal Muscular Atrophy (SMA), for example, is a debilitating and sometimes lethal disease in children. SMA is monogenic, autosomal recessively inherited disorder caused by a loss-of-function mutation of surviving motor neuron 1 (SMN1). SMN2 is an identical copy of this gene and produces abbreviated transcripts without exon 7 though some full transcripts are produced that ameliorate the disease. Previous clinical trials for this disease have not produced consistent results. However, in a recent cross-sectional study, biomarkers for SMA (BforSMA), protein candidates and metabolite markers were identified (Finkel et al., 2012). These markers …

Stem Cells As A Cure For Amyotrophic Lateral Sclerosis, Chaya K. Hirsch

The Science Journal of the Lander College of Arts and Sciences

Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease which affects approximately 30,000 Americans at any given time (alsa.org, 2010). The etiology of this terminal disease unfortunately remains an unsolved mystery and has therefore severely limited the ability to find a cure. The use of stem cells to regenerate neurons has been vastly studied and have produced very promising results. However, its practicality as a cure or treatment for neurodegenerative diseases, such as ALS, is greatly compromised. Three different therapies involving stem cells were examined, Embryonic Stem Cells (ESC), induced pluripotent stem cells, (iPSC) and direct reprogramming of adult …

ปูมแพทย์จุฬา ตอนที่ 5, Pichet Sampaatanukul

Chulalongkorn Medical Journal

No abstract provided.