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Potential Neuroprotective Effect Of Artemisinin In A Rotenone-Induced Mice Model Of Parkinson’S Disease, Nada M. Hamada, Hanan Eissa, Nirmeen Megahed, Mohamed H. Daba, Ahlam Elmasry
Potential Neuroprotective Effect Of Artemisinin In A Rotenone-Induced Mice Model Of Parkinson’S Disease, Nada M. Hamada, Hanan Eissa, Nirmeen Megahed, Mohamed H. Daba, Ahlam Elmasry
Mansoura Medical Journal
Background: Parkinson’s disease (PD) is characterized by motor dysfunctions including tremors, rigidity and bradykinesia. Medications for PD alleviate motor symptoms rather than targeting disease pathogenesis. Recently discovered features of artemisinin suggested that it might be used to treat neurodegenerative diseases. Objective: to explore the possible neuroprotective effect of artemisinin in different doses in a rotenone-induced model of PD. Materials & methods: Twenty-five mice were randomly divided into five groups: group 1; negative-control, group 2; positive-control, and groups 3&4&5: artemisinin-treated (30, 40 and 50 mg/kg) respectively. For PD induction, rotenone (3mg/Kg/day) was administered intraperitoneally for 42 days (6 weeks). Behavioral assessment …