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Cannabinoid Receptor Expression And Phosphorylation Are Differentially Regulated Between Male And Female Cerebellum And Brain Stem After Repeated Stress: Implication For Ptsd And Drug Abuse, Guoqiang Xing, Janis Carlton, Lei Zhang, Xiaolong Jiang, Carol Fullerton, He Li, Robert Ursano
Cannabinoid Receptor Expression And Phosphorylation Are Differentially Regulated Between Male And Female Cerebellum And Brain Stem After Repeated Stress: Implication For Ptsd And Drug Abuse, Guoqiang Xing, Janis Carlton, Lei Zhang, Xiaolong Jiang, Carol Fullerton, He Li, Robert Ursano
Uniformed Services University of the Health Sciences
Recent study demonstrated a close relationship between cerebellum atrophy and symptom severity of pediatric maltreatment-related posttraumatic stress disorder (PTSD). It has also been known that females are more vulnerable than males in developing anxiety disorders after exposure to traumatic stress. The mechanisms are unknown. Because cannabinoid receptors (CB1 and CB2) are neuroprotective and highly expressed in the cerebellum, we investigated cerebellar CB expression in stressed rats. Young male and female Sprague-Dawley rats were given 40 unpredictable electric tail-shocks for 2 h daily on 3 consecutive days. CB1 and CB2 mRNA and protein levels in rat …