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Full-Text Articles in Medicine and Health Sciences
Pten Function In Postnatal Brain Development And Tumorigenesis, Guo Zhu
Pten Function In Postnatal Brain Development And Tumorigenesis, Guo Zhu
Theses and Dissertations (ETD)
PTEN (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase antagonizing phosphorylation by phosphatidylinositol‑3‑OH kinases (PI3Ks) and thus serves as a major negative regulator of the PI3K pathway. Homozygous Pten knock-out mice die during embryogenesis. Conditional Pten knock-out in the nervous system showed that Pten negatively regulates self-renewal and proliferation of neural stem cells, negatively controls neuronal size, is required for proper neuronal positioning and is involved in the development and …
Expression Of Lpp3 In Bergmann Glia Is Required For Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling And Development, Alejandro Lopez-Juarez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J. Morris, Diana Escalante-Alcalde
Expression Of Lpp3 In Bergmann Glia Is Required For Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling And Development, Alejandro Lopez-Juarez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J. Morris, Diana Escalante-Alcalde
Health & Biomedical Sciences Faculty Publications and Presentations
Bioactive lipids serve as intracellular and extracellular mediators in cell signaling in normal and pathological conditions. Here we describe that an important regulator of some of these lipids, the lipid phosphate phosphatase-3 (LPP3), is abundantly expressed in specific plasma membrane domains of Bergmann glia (BG), a specialized type of astrocyte with key roles in cerebellum development and physiology. Mice selectively lacking expression of LPP3/Ppap2b in the nervous system are viable and fertile but exhibit defects in postnatal cerebellum development and modifications in the cytoarchitecture and arrangement of BG with a mild non-progressive motor coordination defect. Lipid and gene profiling studies …
Avian Cerebellum Specialization In Relation To Acrobatic Courtship Displays In Manakins (Pipridae), Steven Ray Wilkening
Avian Cerebellum Specialization In Relation To Acrobatic Courtship Displays In Manakins (Pipridae), Steven Ray Wilkening
Electronic Theses and Dissertations
The courtship displays of male manakins (Pipridae) involve an array of acrobatic and postural elements. Previously it was found that species with elaborate displays exhibit specializations in motor planning and coordination areas of the brain. Several studies have suggested a relationship between cerebellum (Cb) morphology and distinct motor-related functions for the anterior Cb (somatosensory, flying, hopping/walking), posterior Cb (vision, audition, flying, hopping/walking), and vestibular Cb (flying, hopping/walking, vestibular). The anterior, posterior and vestibular Cb as well as basic morphological features of the Cb were measured and tested for a relationship with courtship display complexity in manakins. I compared Cb morphology …
Cannabinoid Receptor Expression And Phosphorylation Are Differentially Regulated Between Male And Female Cerebellum And Brain Stem After Repeated Stress: Implication For Ptsd And Drug Abuse, Guoqiang Xing, Janis Carlton, Lei Zhang, Xiaolong Jiang, Carol Fullerton, He Li, Robert Ursano
Cannabinoid Receptor Expression And Phosphorylation Are Differentially Regulated Between Male And Female Cerebellum And Brain Stem After Repeated Stress: Implication For Ptsd And Drug Abuse, Guoqiang Xing, Janis Carlton, Lei Zhang, Xiaolong Jiang, Carol Fullerton, He Li, Robert Ursano
Uniformed Services University of the Health Sciences
Recent study demonstrated a close relationship between cerebellum atrophy and symptom severity of pediatric maltreatment-related posttraumatic stress disorder (PTSD). It has also been known that females are more vulnerable than males in developing anxiety disorders after exposure to traumatic stress. The mechanisms are unknown. Because cannabinoid receptors (CB1 and CB2) are neuroprotective and highly expressed in the cerebellum, we investigated cerebellar CB expression in stressed rats. Young male and female Sprague-Dawley rats were given 40 unpredictable electric tail-shocks for 2 h daily on 3 consecutive days. CB1 and CB2 mRNA and protein levels in rat …
Cerebrocerebellar Hypometabolism Associated With Repetitive Blast Exposure Mild Traumatic Brain Injury In 12 Iraq War Veterans With Persistent Post-Concussive Symptoms, Elaine R. Peskind, Eric C. Petrie, Donna J. Cross, Kathleen Pagulayan, Kathleen Mccraw, David Hoff, Kim Hart, Chang-En Yu, Murray A. Raskind, David G. Cook, Satoshi Minoshima
Cerebrocerebellar Hypometabolism Associated With Repetitive Blast Exposure Mild Traumatic Brain Injury In 12 Iraq War Veterans With Persistent Post-Concussive Symptoms, Elaine R. Peskind, Eric C. Petrie, Donna J. Cross, Kathleen Pagulayan, Kathleen Mccraw, David Hoff, Kim Hart, Chang-En Yu, Murray A. Raskind, David G. Cook, Satoshi Minoshima
Public Health Resources
Disagreement exists regarding the extent to which persistent post-concussive symptoms (PCS) reported by Iraq combat Veterans with repeated episodes of mild traumatic brain injury (mTBI) from explosive blasts represent structural or functional brain damage or an epiphenomenon of comorbid depression or posttraumatic stress disorder (PTSD). Objective assessment of brain function in this population may clarify the issue. To this end, twelve Iraq war Veterans (32.0±8.5 [mean±standard deviation (SD)] years of age) reporting one or more blast exposures meeting American Congress of Rehabilitation Medicine criteria for mTBI and persistent PCS and 12 cognitively normal community volunteers (53.0±4.6 years of age) without …