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Full-Text Articles in Medicine and Health Sciences
Yellow Fever Vaccine: An Updated Assessment Of Advanced Age As A Risk Factor For Serious Adverse Events, Alena Y. Khromava, Rachel Barwick Eidex, Leisa H. Weld, Katrin S. Kohl, Robert D. Bradshaw, Robert T. Chen, Martin S. Cetron
Yellow Fever Vaccine: An Updated Assessment Of Advanced Age As A Risk Factor For Serious Adverse Events, Alena Y. Khromava, Rachel Barwick Eidex, Leisa H. Weld, Katrin S. Kohl, Robert D. Bradshaw, Robert T. Chen, Martin S. Cetron
Uniformed Services University of the Health Sciences
Since 1996, the scientific community has become aware of 14 reports of yellow fever vaccine (YEL)-associated viscerotropic disease (YEL-AVD) cases and four reports of YEL-associated neurotropic disease (YEL-AND) worldwide, changing our understanding of the risks of the vaccine. Based on 722 adverse event reports after YEL submitted to the U.S. Vaccine Adverse Event Reporting System in 1990–2002, we updated the estimates of the age-adjusted reporting rates of serious adverse events, YEL-AVD and YEL-AND.We found that the reporting rates of serious adverse events were significantly higher among vaccinees aged ≥60 years than among those 19–29 years of age (reporting rate ratio …
Factor Structure And Construct Validity Of The Anxiety Sensitivity Index Among Island Puerto Ricans, Jennifer A. Cintrón, Michele M. Carter, Sonia Suchday, Tracy Sbrocco, James Gray
Factor Structure And Construct Validity Of The Anxiety Sensitivity Index Among Island Puerto Ricans, Jennifer A. Cintrón, Michele M. Carter, Sonia Suchday, Tracy Sbrocco, James Gray
Uniformed Services University of the Health Sciences
The factor structure and convergent and discriminant validity of the Anxiety Sensitivity Index (ASI) were examined among a sample of 275 island Puerto Ricans. Results from a confirmatory factor analysis (CFA) comparing our data to factor solutions commonly reported as representative of European American and Spanish populations indicated a poor fit. A subsequent exploratory factor analysis (EFA) indicated that a two-factor solution (Factor 1, Anxiety Sensitivity; Factor 2, Emotional Concerns) provided the best fit. Correlations between the ASI and anxiety measures were moderately high providing evidence of convergent validity, while correlations between the ASI and BDI were significantly lower providing …
Targeting Of Tsc13p To Nucleus–Vacuole Junctions: A Role For Very-Long-Chain Fatty Acids In The Biogenesis Of Microautophagic Vesicles, Erik Kvam, Kenneth Gable, Teresa M. Dunn, David S. Goldfarb
Targeting Of Tsc13p To Nucleus–Vacuole Junctions: A Role For Very-Long-Chain Fatty Acids In The Biogenesis Of Microautophagic Vesicles, Erik Kvam, Kenneth Gable, Teresa M. Dunn, David S. Goldfarb
Uniformed Services University of the Health Sciences
TSC13 is required for the biosynthesis of very-long-chain fatty acids (VLCFAs) in yeast. Tsc13p is a polytopic endoplasmic reticulum (ER) membrane protein that accumulates at nucleus–vacuole (NV) junctions, which are formed through Velcro-like interactions between Nvj1p in the perinuclear ER and Vac8p on the vacuole membrane. NV junctions mediate piecemeal microautophagy of the nucleus (PMN), during which bleb-like portions of the nucleus are extruded into invaginations of the vacuole membrane and degraded in the vacuole lumen. We report that Tsc13p is sequestered into NV junctions from the peripheral ER through Vac8p-independent interactions with Nvj1p. During nutrient limitation, Tsc13p is incorporated …