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In Vitro Effects Of Some Anthelminthics On Themalate Dehydrogenase And Lactate Dehydrogenaseenzyme Activities Of Taenia Saginata, A. Yasemi̇n Öztop, Gülendame Saygi, H. Nursevi̇n Öztop
In Vitro Effects Of Some Anthelminthics On Themalate Dehydrogenase And Lactate Dehydrogenaseenzyme Activities Of Taenia Saginata, A. Yasemi̇n Öztop, Gülendame Saygi, H. Nursevi̇n Öztop
Turkish Journal of Medical Sciences
Malate Dehydrogenase (MDH) and Lactate Dehydrogenase (LDH) activities were demonstrated in the mitochondrial and cytosolic fractions of an intestinal cestode, Taenia saginata, and then the in vitro effects of three anthelminthics, albendazole, niclosamide, and piperazine on these enzymes were investigated. The Vmax and Km values of MDH were found to be 3.00 \mumol (min mg protein) -1 and 0.0166 mM respectively. In vitro addition of albendazole and niclosamide increased the Vmax value of MDH, whereas it decreased Km value of MDH (p