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Full-Text Articles in Medicine and Health Sciences
Myelin-Associated Glycoprotein Interacts With Neurons Via A Sialic Acid Binding Site At Arg118 And A Distinct Neurite Inhibition Site, Song Tang, Ying Jing Shen, Maria Elena Debellard, Gitali Mukhopadhyay, James L. Salzer, Paul R. Crocker, Marie T. Filbin
Myelin-Associated Glycoprotein Interacts With Neurons Via A Sialic Acid Binding Site At Arg118 And A Distinct Neurite Inhibition Site, Song Tang, Ying Jing Shen, Maria Elena Debellard, Gitali Mukhopadhyay, James L. Salzer, Paul R. Crocker, Marie T. Filbin
Publications and Research
Inhibitory components in myelin are largely responsible for the lack of regeneration in the mammalian CNS. Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo. Here, we show that MAG’s sialic acid binding site is distinct from its neurite inhibitory activity. Alone, sialic acid–dependent binding of MAG to neurons is insufficient to effect inhibition of axonal growth. Thus, while soluble MAG-Fc (MAG extracellular domain fused to Fc), a truncated form of MAG-Fc missing Ig-domains 4 and 5, MAG(d1-3)-Fc, …
Transcranial Magnetic Stimulation Of The Prefrontal Cortex Delays Contralateral Endogenous Saccades, Tony Ro, Avishai Henik, Liana Machado, Robert D. Rafal
Transcranial Magnetic Stimulation Of The Prefrontal Cortex Delays Contralateral Endogenous Saccades, Tony Ro, Avishai Henik, Liana Machado, Robert D. Rafal
Publications and Research
The contributions of the superior prefrontal cortex (SPFC) and the superior parietal lobule (SPL) in generating voluntary endogenous and reflexive visually guided saccades were investigated using transcranial magnetic stimulation (TMS). Subjects made choice saccades to the left or right visual field in response to a central arrowhead (endogenous go signal) or a peripheral asterisk (exogenous go signal) that were presented along with a single TMS pulse at varying temporal intervals. TMS over the SPFC increased latencies for saccades made in response to an endogenous go signal toward the contralateral hemifield. No effects were observed when the go signal was exogenous …
Effects Of A Sugar-Free Hypoallerdenic Diet And Nutrtional Supplementation On Ulcerative Colitis, William (Bill) H. Williams, Robert C. Atkins Md, Joel S. Edman
Effects Of A Sugar-Free Hypoallerdenic Diet And Nutrtional Supplementation On Ulcerative Colitis, William (Bill) H. Williams, Robert C. Atkins Md, Joel S. Edman
Publications and Research
Few clinical studies have found that dietary or nutritional factors significantly influence ulcerative colitis (UC}(l,2}. It is noteworthy, however, that a range of factors have been researched including dietary components such as refined sugars (3,4}, allergenic foods (1,5,6} and fast foods (7), as well as nutritional supplement effects from fish oil (2), zinc (8), glutamine (9), folate (10, 11} and alpha-tocopherolquinone (12}. More recently investigators have also examined the interelationships between bowel flora and UC, including factors such as flora changes (13,14), endotoxemia (15} and supplementation effects with Lactobacillous species (16,17). These studies taken together and a recent review of …
Minor Physical Anomalies: Modifiers Of Environmental Risk For Psychopathology, Daniel S. Pine, David Shaffer, Irvin Sam Schonfeld, Mark Davies
Minor Physical Anomalies: Modifiers Of Environmental Risk For Psychopathology, Daniel S. Pine, David Shaffer, Irvin Sam Schonfeld, Mark Davies
Publications and Research
Tested the hypothesis that minor physical anomalies (MPAs) modify an adolescent's vulnerability to environmental risk factors for psychopathology. 118 male 17-yr-olds who had been evaluated as 7-year-olds received a comprehensive neuropsychiatric evaluation. The evaluation included standardized assessments of environmental risk factors for psychiatric impairment, neurological signs, IQ, MPAs, and psychiatric impairment. The relationship between psychiatric status and environmental risk was examined as a function of the MPA profile. There was a significant interaction between MPAs and environmental risk in predicting psychiatric status. Environmental risk was more predictive of psychiatric impairment at age 17 in Ss with high scores on the …
Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth
Psychiatric Outcomes In Low Birthweight Children At Age Six: Relation To Neonatal Cranial Ultrasound Abnormalities, Agnes H. Whitaker, Ronan Van Rossem, Judy F. Feldman, Irvin Sam Schonfeld, Jennifer A. Pinto-Martin, Carolyn Torre, David Shaffer, Nigel Paneth
Publications and Research
Examined the relation of neonatal cranial ultrasonography abnormalities to later psychiatric disorder in 564 low birth weight children (aged 5.2–8.7 yrs). Psychiatric diagnoses were assessed by means of the Diagnostic Interview Schedule for Children–Parent version, and detailed information was collected on other predictors and outcomes. Results show that 454 Ss had no cranial abnormalities, 78 had germinal matrix hemorrhage (GMH) and/or intraventricular hemorrhage (IVH), and 32 had a parenchymal lesion (PL) or ventricular enlargement (VE). 22% of the Ss had at least 1 psychiatric disorder, the most common being attention deficit hyperactivity disorder (ADHD). Isolated GMH/IVH did not increase …