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Full-Text Articles in Medicine and Health Sciences
Viruses And The Conntective Tissue Diseases, Morris Ziff
Viruses And The Conntective Tissue Diseases, Morris Ziff
MCV/Q, Medical College of Virginia Quarterly
A number of observations in the last few years have attracted attention to the possibility of viral infection in systemic lupus erythematosus (SLE). One of these is the occurrence of interwoven tubular structures, usually in the endothelial cells of the kidney but also in the lymphocytes and in fibroblasts when SLE skin fibroblasts are cultured. These tubular structures have resembled viruses (they were thought by their discoverers to be myxo- or paramyxoviruses), but it has been argued that they are not viruses because of their size and appearance and because they have been produced in tissue cultures from subjects who …
The "Three R'S" Of Delayed Hypersensitivity, David Horwitz
The "Three R'S" Of Delayed Hypersensitivity, David Horwitz
MCV/Q, Medical College of Virginia Quarterly
Delayed hypersensitivity is one of several immune responses initiated by thymus-derived (T) lymphocytes. The mononuclear infiltrate of delayed hypersensitivity is a collaborative phenomenon between T lymphocytes and monocytes. This collaboration can be separated into components which I have chosen to call the "three R's" of delayed hypersensitivity. In this discussion I will define these "three R's" and examine the usefulness of this concept in clinical medicine.
Juvenile Rheumatoid Arthritis: Early Diagnosis, Management, And Prognosis, John J. Calabro
Juvenile Rheumatoid Arthritis: Early Diagnosis, Management, And Prognosis, John J. Calabro
MCV/Q, Medical College of Virginia Quarterly
Rheumatoid arthritis (RA) is the major chronic rheumatic disorder of childhood. It affects as many as 250,000 American children and is slightly more common in girls than boys.
Modern Immunology: Cells And Molecules, Franklin Mullinax
Modern Immunology: Cells And Molecules, Franklin Mullinax
MCV/Q, Medical College of Virginia Quarterly
In this presentation I shall discuss 1) some historical highlights n the field of immunology; 2) the molecules of immunity, particularly the immunoglobulins; and 3) the cells of immunity, particularly the immunocytes. This presentation may provide a background for subsequent articles.
Introduction, Robert Irby
Introduction, Robert Irby
MCV/Q, Medical College of Virginia Quarterly
The 45th Annual McGuire Lecture Series has been devoted to the subject of Immunology and the Rheumatic Diseases. In this two-day period, 22 outstanding physicians in the field of immunology and rheumatology brought an up-to-date overall concept in the field of rheumatic diseases. Subjects included not only aspects of pathogenesis but also modern laboratory methods in the diagnosis of various connective tissues diseases. The remedial surgical approaches for prevention of pain and disability in rheumatoid arthritis were discussed from a practical viewpoint.
A Review Of Some Aspects Of L-Forms And Gonococci, Charles L. Cooke, Bernard Germain, Bonnie Balducci, Harry P. Dalton
A Review Of Some Aspects Of L-Forms And Gonococci, Charles L. Cooke, Bernard Germain, Bonnie Balducci, Harry P. Dalton
MCV/Q, Medical College of Virginia Quarterly
Systemic manifestations of gonococcal disease, such as arthritis, are often sterile on the usual culture methods used to grow gonococci. Allergic mechanisms have been invoked to explain this but with little evidence to support the concept. With the report by Holmes et al., that L-forms of gonococci were isolated from joint fluid of a patient with gonococcal arthritis, we decided to investigate the possible role of L-forms in gonococcal disease.
Immune Complex Reactions In Systemic Lupus Erythematosus, John Staige Davis Iv
Immune Complex Reactions In Systemic Lupus Erythematosus, John Staige Davis Iv
MCV/Q, Medical College of Virginia Quarterly
We should first try to define systemic lupus erythematosus (SLE). Table 1 lists criteria proposed by a committee of the American Rheumatism Association. If four of these 14 major criteria are positive, then there should be about 98% specificity for SLE. There are clearly many facets to this disorder. Let us consider mechanisms that might account for a multisystem disease such as this.
Summary Of Papers Presented At The 45th Annual Mcguire Lecture Series, Robert Irby
Summary Of Papers Presented At The 45th Annual Mcguire Lecture Series, Robert Irby
MCV/Q, Medical College of Virginia Quarterly
It is the purpose of this presentation to quickly review some of the important points of the papers which were presented at the 45th Annual McGuire Lecture Series on the subject of immunology and rheumatic diseases.
Anklylosing Spondylitis, John Baum
Anklylosing Spondylitis, John Baum
MCV/Q, Medical College of Virginia Quarterly
Within the last few years, the study of ankylosing spondylitis has produced some of the more remarkable new developments in the field of the rheumatic diseases. In modern days the disease has been described in Germany by Strümpell and in France by Marie. As a result, in Germany it is known as Strümpell's disease and in France as Marie's disease. Physicians in the United States and England, to be fair, call it Marie-Strümpell disease. It should be emphasized at this point that ankylosing spondylitis is not a variant of rheumatoid arthritis as it had been considered for a number of …
Histocompatibility Antigens And Spondylitis, Robert Irby, William Edwards, James Pierce, Roderick Macdonald
Histocompatibility Antigens And Spondylitis, Robert Irby, William Edwards, James Pierce, Roderick Macdonald
MCV/Q, Medical College of Virginia Quarterly
This is a transcript of a discussion about HL-A antigens and spondylitis at Medical Grand Rounds by the Department of Medicine, Surgery, and Ophthalmology on January 29, 1974, at the Medical College of Virginia, Richmond.
Introduction, Robert Irby
Introduction, Robert Irby
MCV/Q, Medical College of Virginia Quarterly
This issue of the MCV/Q is a continuation of the first issue of this year, which was devoted to the subject of Immunology and the Rheumatic Diseases. Many of the papers presented at the 45th Annual McGuire Lecture Series were published in the first issue and this will complete those papers which were submitted for publication.
Onset Of The Immune Response, S. G. Bradley
Onset Of The Immune Response, S. G. Bradley
MCV/Q, Medical College of Virginia Quarterly
In our studies on the primary immune response, we have used germfree, colostrum-deprived swine taken three to five days prematurely by hysterectomy. These piglets lack gamma globulin until they are immunized. Upon antigenic stimulation, early macroglobulin antibody is produced within 48 hours; subsequently late euglobulin antibody is produced. Our results have led me to formulate a new instructive model for the onset of antibody formation.
The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
MCV/Q, Medical College of Virginia Quarterly
The total complex of immune expression is an interplay between nonspecific antimicrobial humoral systems plus specific antibodies and accessory factors. These systems are backstopped by the phagocytic functions of PMNs. If these fail, mononuclear phagocytes respond as a second line of defense to carry out chronic engagements. In addition to a direct activation process by "substrate," macrophages may be activated and mobilized by a lymphocyte-mediated immunologic reaction which probably involves either a "lymphotoxin" and/or a specific antibody cytophilic for macrophages. Immunologically activated lymphocytes appear to be the primary effector cells of anti-tissue (transplantation) cellular immunity, whereas immunologically activated macrophages appear …