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Onset Of The Immune Response, S. G. Bradley
Onset Of The Immune Response, S. G. Bradley
MCV/Q, Medical College of Virginia Quarterly
In our studies on the primary immune response, we have used germfree, colostrum-deprived swine taken three to five days prematurely by hysterectomy. These piglets lack gamma globulin until they are immunized. Upon antigenic stimulation, early macroglobulin antibody is produced within 48 hours; subsequently late euglobulin antibody is produced. Our results have led me to formulate a new instructive model for the onset of antibody formation.
The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
MCV/Q, Medical College of Virginia Quarterly
The total complex of immune expression is an interplay between nonspecific antimicrobial humoral systems plus specific antibodies and accessory factors. These systems are backstopped by the phagocytic functions of PMNs. If these fail, mononuclear phagocytes respond as a second line of defense to carry out chronic engagements. In addition to a direct activation process by "substrate," macrophages may be activated and mobilized by a lymphocyte-mediated immunologic reaction which probably involves either a "lymphotoxin" and/or a specific antibody cytophilic for macrophages. Immunologically activated lymphocytes appear to be the primary effector cells of anti-tissue (transplantation) cellular immunity, whereas immunologically activated macrophages appear …