Medicine and Health Sciences Commons^™

Estimating Root Volumes By Limited Segmentation: A Volumetric Analysis Of Cbct And Micro-Ct Data, Theresa C. Baldwin

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The increased dimensional accuracy of images provided by cone beam computed tomography (CBCT) scans allows for more in-depth diagnosis and treatment planning. Expedient interpolation of segmented data that provides clinically acceptable results will encourage clinicians to frequently use CBCT images for clinical/radiographic evaluation. Some of these applications include, quantification of root resorption, determination of force required for specific tooth movements, and customized appliances. Purpose: The study had two purposes. The first was to compare the accuracy of digital tooth volumes acquired from CBCT to the gold standard, micro-computed tomography (micro-CT). The second was to determine the effect of axial …

The Relationship Between Psychotherapist Personality And Therapeutic Alliance, Michael Finlay

Loma Linda University Electronic Theses, Dissertations & Projects

Time-limited effective psychotherapy is a topic that is frequently addressed in clinical therapy research. Though a wide range of therapeutic factors, expectancy effects, techniques, and extratherapeutic have all been demonstrated to be related to outcome, researchers have consistently identified the therapeutic alliance as one of the strongest factors in predicting psychotherapy outcomes. Researchers are beginning to measure the effectiveness of therapy by evaluating improvements in outcome measures, and client reported therapeutic alliance. Researchers have recently began investigating the common personality profiles among psychotherapists, and have hypothesized that there is a relationship between psychotherapist personality and therapeutic alliance. The goal of …

Using The Theory Of Planned Behavior To Understand Student Compliance To Tobacco-Free Policies In California Universities, Harit Agroia

Loma Linda University Electronic Theses, Dissertations & Projects

Background: In California, the mortality rate associated with smoking ranks as the sixth highest among all states in the nation (CDPH, 2016). To reduce this rate, many universities in California have adopted tobacco-free policies in recent years (Mamudu, Veeranki, Kioko, Boghozian & Littleton, 2016). Due to the recent adoption of such policies, there is limited research available which aim to assess the effectiveness of these on tobacco use behavior on campus among university students.

Purpose: The purpose of this study was to understand student compliance to tobacco-free policies within select universities in California, specifically those that implemented their …

A Novel Exo-Proteomic Approach To The Study Of Traumatic Brain Injury, Ron B. Moyron

Loma Linda University Electronic Theses, Dissertations & Projects

Concussions and Traumatic Brain Injuries (TBI) are significant health concerns and affect a wide cross section of society. Current diagnostic criteria and modalities, such as brain imaging and subjective measures of consciousness such as the Glasgow Coma Scale (GCS) score, are insufficient to properly diagnose the full spectrum of head injuries. Assessment of injury severity and outcome are further complicated by the vast array of symptoms, many of which mimic those displayed by other disorders. It is important to possess a better diagnostic tool for head injury triage and outcome prediction. One current line of inquiry seeks to discover a …

Neuroprotective Functions Of Docosahexaenoic Acid And Epidermal Fatty Acid Binding Protein, Manuel Luis Montero

Loma Linda University Electronic Theses, Dissertations & Projects

Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition of necroptosis and promotion of autophagy do. DHA decreases the expression of HIF-1α and BNIP3 and rescues PA-induced cell death by inhibiting apoptosis and necroptosis. Besides DHA stimulates the mRNA expression, phosphorylation and conjugation of autophagy controlling proteins. Inhibiting autophagy during DHA treatment decreases its capacity …

Saudi Nurse Knowledge, Cultural Perspective, And Intent Regarding Cervical Cancer Prevention, Alaa Mujallad

Loma Linda University Electronic Theses, Dissertations & Projects

Cervical cancer can be controlled by providing screening and vaccination. Although rates for this female cancer are decreasing in developed countries, these low rates are not observed in the other countries. In Saudi Arabia, cervical cancer cases are increasing dramatically (from only 152 cases in 2014, to 241 cases in 2017). Lack of knowledge about cervical cancer prevention presumably contributes to the morbidity and mortality rate among Saudi women, as do religio-cultural beliefs about modesty, sexuality, and premarital virginity. Therefore, this study sought to describe how Saudi nurses’ knowledge and religio-cultural beliefs effected their intentions to promote cervical cancer prevention. …

In-Vitro Evaluation Of Accuracy Of Conventional And Cad/Cam Removable Partial Denture Frameworks, Pooya Soltanzadeh

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: Computer-aided design/computer-aided manufacturing (CAD/CAM) technology is gaining popularity in dentistry, and more recently, to fabricate removable partial dentures (RPD). The purpose of this study was 1) to evaluate the overall accuracy and fit of conventional versus CAD/CAM fabricated printed RPD frameworks based on STL data analysis, and 2) to evaluate the accuracy and fit of each component of the RPD framework. Materials and Methods: A maxillary metal framework was designed for a Kennedy class III modification I situation. The master model was scanned and used to compare the fit and accuracy of the RPD frameworks. A total of 40 …

Aminoflavone Inhibits Α6-Integrin And Growth Of Tamoxifen Resistant Breast Cancer, Petreena S. Campbell

Loma Linda University Electronic Theses, Dissertations & Projects

Approximately 40% of estrogen receptor positive (ER+) breast cancer patients develop resistance to standard of care agent tamoxifen, while ER negative (ER-) breast cancer patients are intrinsically resistant to tamoxifen. Resistance often promotes metastasis, recurrence and death. Tumor-initiating cells (TICs) represent key contributors to resistance and adhesion protein α6-integrin is a putative TIC biomarker. Investigational agent Aminoflavone (AF) demonstrates efficacy against breast cancer cells irrespective of ER status. Interestingly, we found tamoxifen resistant (TamR) cells and tumors exhibited elevated α6-integrin expression in comparison to their tamoxifen sensitive counterparts. AF effectively disrupted mammospheres enriched for TICs and reduced α6-integrin levels in …

Reliability And Accuracy Of A Novel Photogrammetric Orthodontic Monitoring System, Vahe Ohanesian

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This study quantitatively investigated the reliability and accuracy of Dental Monitoring’sTM proprietary orthodontic tracking system in comparison to an established reference. Materials and Methods: Intraoral scans (True Definition Scanner, 3MTM) and video scans (iPhone 7, AppleTM) were taken of 30 subjects undergoing comprehensive orthodontic treatment at Loma Linda University’s Graduate Orthodontic Clinic at T1 (initial) and T2 (3 months later). At each time point, an intraoral scan was taken by the operator followed by three video scans- two taken by the patient and one by the operator. Three linear and three angular measurements were analyzed using Dental Monitoring’sTM tracking …

Accuracy Of Cephalometric Analyses And Tooth Movements Of Conventional Vs Cbct-Generated Cephalograms, Thanh Khong Ng

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The aim of this study was to compare Ricketts and American Board of Orthodontics (ABO) cephalometric measurements and tooth movements from tracings between conventional lateral cephalograms (Sirona Orthophos XG Plus, Charlotte, NC) and CBCT-generated cephalograms (NewTom 5G; QR srl, Verona, Italy). Materials and Methods: Patients who had bilateral Angle’s class II molar were evaluated. Pre-treatment (T1) and post-treatment (T2) conventional lateral cephalograms (CLCs) and CBCT-generated lateral cephalograms (CBLCs) were traced in Quick Ceph Studio using Ricketts and ABO cephalometric analyses. Linear and angular cephalometric measurements from tracings were compared between the two radiographic modalities using one-sample Wilcoxon signed rank …

A Retrospective Cephalometric Growth Study Of Sagittal Airway In Skeletal Class Ii Patients, Sue V. Kim

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The study retrospectively determined the average sagittal pharyngeal airway widths in Class II males and females between 7 to 16 years of age and changes in sagittal airway with increasing age. Additionally, this study determined whether average airway differs between gender at each age and compared the average airway widths in relation to increasing age between Class I and II patients. Materials and Methods: Longitudinal cephalograms were digitally traced for 38 untreated subjects (23 males, 15 females) from age 7 to 16 with skeletal and dental Class II patterns. These records were previously taken through growth studies conducted between …

An Empirical Examination Of Doctoral Training Models In Clinical Psychology In The United States, Katherine E. Dautenhahn

Loma Linda University Electronic Theses, Dissertations & Projects

Since as early as 1908, psychology as a discipline has grappled with how to integrate research and practice into the field’s professional identity. To further define the area of expertise of a psychologist, three main models of clinical training have been proposed: the scientist-practitioner model, the practitioner-scholar model, and the clinical scientist model. Despite clinical psychology’s universal claim for empirical moorings, the debate about the foundation of training in clinical psychology has remained primarily theoretical. The purpose of this study is to expand upon the limited research exploring the differences between training models to empirically determine which factors significantly predicted …

Measuring A Sample Of Orthodontic Models/Panographs At Llusd Using The Cr-Eval, Jonathan Michael Drew

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: An index must be used to quantify the improvement in the position of teeth treated by orthodontics. The Cast-Radiograph Evaluation is the index used by the American Board of Orthodontics. The purpose of this study is to use this index to evaluate treatment outcomes in the graduate orthodontic clinic at Loma Linda University from 2012-2016. Materials and Methods: Patients included were comprehensively treated, debonded between 1/1/2012 and 12/31/2016, and under age 30. A total of 80 patients were randomly selected, with 16 coming from each year. The ABO DI was used to score the T1 models, and the CR-Eval …

Healthy Aging: Factors That Predict Preservation Of Cognitive Functioning In Older Adults, Imari-Ashley F. Palma

Loma Linda University Electronic Theses, Dissertations & Projects

As the human race continues to defy chronological aging in due part to medical advancements, an overarching goal for the older adult population and researchers is to determine how to promote aging well. Cognitive functioning is a heavily researched area due to the exponentially increasing number of older adults experiencing cognitive decline. Preservation of cognitive functioning is one aspect of aging well. Three domains of cognition that have shown to be particularly sensitive to the effects of aging are memory, executive functioning, and processing speed. The aims of this current study are: (i) to provide supporting evidence for research that …

The Wear Of Acrylic Resin And Composite Resin Teeth Against Polished And Glazed Zirconia, Abdulkareem Alshehri

Loma Linda University Electronic Theses, Dissertations & Projects

Background: Excessive wear for the occlusal surfaces of teeth results in decreased masticatory efficiency, poor esthetics and leads to reduced the occlusal vertical dimension which could lead to the development of temporomandibular disorders, consequently, further compromise function. Very few studies have been performed on the wear resistance of zirconia against artificial denture teeth and human enamel. Aim: The purpose of this study was to investigate the influence of polished zirconia (PZ) and glazed zirconia (GZ) on the 2-body wear resistance (vertical substance loss) of seven commercially available denture teeth made of different resins. Material and Method: Eight groups (n=10) of …

Rna-Seq Reveals Transcriptomic Program Associated With Stemness In Taxane Resistant Prostate Cancer, Christina K. Cajigas-Du Ross

Loma Linda University Electronic Theses, Dissertations & Projects

There is no cure for advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the benchside, but clinical trials have not resulted in newly approved drugs due in part to redundant survival pathways utilized by prostate tumor cells to maintain therapy-resistance. Using RNAsequencing—an innovative approach for quantifying gene expression changes—this dissertation sought to elucidate chemoresistance-associated molecular pathways as a catalyst to develop new therapeutic targets. Results revealed a differential upregulation of stemness-associated genes …

Effect Of Adding Stretching Techniques To Standardized Intervention On Nonspecific Mechanical Neck Pain, Saad S. Alfawaz

Loma Linda University Electronic Theses, Dissertations & Projects

Mechanical neck pain is becoming one of the leading causes of musculoskeletal disorders in the general adult population. Mobilization intervention is considered one of the most effective therapeutic techniques to treat non-specific neck pain. The purpose of this study was to investigate the benefit of adding stretching exercises as part of a rehabilitation program for patients with non-specific mechanical neck pain. Methods: Thirty-eight subjects with non-specific neck pain for at least 2 weeks with mean± SD age 30.9±8.1 years and body mass index (BMI) 26.8±6.7 kg/m2 participated in the study. Participants were randomly assigned to either the combined intervention (passive …

The Design Of Complex Weapons Systems In Scorpions: Sexual, Ontogenetic, And Interspecific Variation, Gerard A. A. Fox

Loma Linda University Electronic Theses, Dissertations & Projects

Scorpions possess two integrated multifunctional weapons systems. Anteriorly, they maintain a grasping system comprised of a pair of pedipalps ending in chelae that seize and manipulate prey, ward off predators, and secure mates. Posteriorly, they wield a venom delivery system consisting of a tail-like metasoma with a stinger at the tip of the terminal segment (telson) that can be thrust into prey, predators, or mates to inject venom. Given the complexity of these systems, I hypothesized that weaponry design is subject to selective forces arising from differences in usage between the sexes, during ontogeny, and among closely-related species occupying different …

Changes In The Morphology Of Hypoglossal Motor Neurons In The Brainstem Of Developing Rats, Paul Allen Williams

Loma Linda University Electronic Theses, Dissertations & Projects

The autonomic brainstem generates and modifies breathing rhythm by integrating inputs from chemo- and mechanosensors in the viscera while coordinating descending outputs from higher CNS structures. Hypoglossal motoneurons (XII MNs) receive inputs from respiratory premotor neurons in the medulla. Previous studies in rodents have demonstrated significant changes in breathing control during the first three weeks of life, with a sensitive period at 10 to 13 days post-birth (P10–P13) characterized by pronounced changes in neurotransmitters, receptors, excitation-inhibition balance, and breathing. However, age-dependent morphological changes of XII MNs during the first three weeks post-birth and especially during this sensitive period, have not …

Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised In Asian Americans, Dean Lim

Loma Linda University Electronic Theses, Dissertations & Projects

Prior research has indicated that the prevalence of eating disorders, which are recognized as one of most lethal psychological disorders with an approximately 20% mortality rate, are increasing among Asian Americans with rates comparable to those of the general population in the United States. However, research has also suggested that Asian Americans may not be fully reporting symptoms related to eating disorders because of sociocultural stigma and the desire to uphold cultural values, such as interdependence, harmony within the community, humility, and emotional restraint. The SATAQ-4R is a widely-used measure of sociocultural influences on body image and eating disturbance, which …

Effect Of High Antioxidant Cacao Consumption On Behaviors In Children With Autism Spectrum Disorder, Amy Sadek

Loma Linda University Electronic Theses, Dissertations & Projects

BACKGROUND- Children with Autism Spectrum Disorder (ASD) demonstrate a physiological imbalance between free radicals, resulting from oxidative stress, and antioxidants. Oxidative stress is linked to the pathogenesis of this neurocognitive disorder. The objectives of this pilot feasibility study: 1) to examine the effect of consumption of high concentration antioxidant cacao on behavior of children as perceived by the child’s teacher and 2) as perceived by the child’s parent. METHODS- This clinical trial was a prospective experimental study. Participants consumed 8 squares (or 16 grams) per day of the dark chocolate which had a concentration of 70% cacao and 30% organic …

Neurocognitive And Psychosocial Effects Of Repeated Concussions In Children And Adolescents, Shina Halavi

Loma Linda University Electronic Theses, Dissertations & Projects

In the United States, an estimated 1.7 million people sustain a traumatic brain injury (TBI) annually. About 75% of these TBIs are mild, which are referred to as “concussions.” This study assessed the neurocognitive and psychosocial effects of repeated concussions in children and adolescents and their interactions with age and gender. It also assessed the correlation between psychosocial functioning and neurocognitive functioning. Given the paucity of research on the effects of concussion in the developing brain, the current study characterized the neurocognitive and psychosocial effects of concussion in young populations. The overarching hypothesis stated that repeated concussions would induce more …

A Digitized Comparison Using Cone Beam Computed Tomography And Intraoral Scanning, Yvette Carrillo

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The purpose of this study was to evaluate the accuracy of digital workflow by evaluating the absolute technical differences in various scanning methods on jaw models with scanning bodies.

Material and Methods: Twenty identical 3-dimensionally printed mandibular quadrant jaw models with a single implant and scanning body replacing a missing tooth in area #19 were examined. Cone beam computed tomography .STL files were used as the first test group. Intraoral scans were used as the second test group. Desktop scans of each model and the .STL file was used as a control. The .STL files were then …

African Americans Navigating Through Relationships Towards Marriage: A Grounded Theory Study, Moosgar Yrveens Borieux

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to explore if and how early parent-participant relationships affect subsequent intimate relationships among African American couples. Given the clear gap between African Americans’ attitudes about marriage and the data that show them to be the least likely to be married among other racial or ethnic groups in the United States of America, a unique conceptualization [Life Course Developmental framework, Object Relations theory, Symbolic Interactionism perspective] was used to explore the role that early key figure-child social interactions potentially have in influencing young African Americans interactions with their significant others. To carry out the research …

Effect Of Bacillus Coagulans And Galactomannans On Obese Patients Undergoing Sleeve Gastrectomy, Fay Kazzi

Loma Linda University Electronic Theses, Dissertations & Projects

Background/Purpose: Obesity is fast becoming a worldwide epidemic. Bariatric Surgery (BS) is an effective treatment to decrease obesity and the risk of associated diseases. The purpose of this study was to examine the effect of probiotics and prebiotics (LactoWise®) on weight loss, clinical lab values, and quality of life in morbidly obese patients undergoing LSG.

Methods: Sixty patients undergoing LSG were recruited to participate in the study and randomized into either a LactoWise® or placebo group. The LactoWise® group received 4.5 billion live cells of bacillus coagulans and galactomannans (300 mg); the placebo group received 600 mg of calcium citrate …

Effects Of Omega-3s And Vitamin E Prophylactic Diets And The Implications Of Lipid Transport In Spinal Cord Injury, Kathia Cordero-Caban

Loma Linda University Electronic Theses, Dissertations & Projects

Traumatic injury to the central nervous system (CNS) presents a devastating problem to our society. Although current interventions are promising, no effective treatments are available. The neural membrane fatty acid composition is markedly altered during the first few days after spinal cord injury (SCI). SCI results in autonomic dysfunction, paralysis, spasticity, and significant chronic neuropathic pain. The trauma leads to significantly increased levels of free radical and oxidative stress that contribute to obstructing tissue healing and recovery. A growing body of evidence shows that administration of hydrophobic molecules such as Vitamin E and long-chain omega-3 polyunsaturated fatty acids (ω3PUFAs) are …

The Relationship Between Plantar Fascia Thickness, Metatarsophalangeal Joint Position And Gender, Michael J. Granado

Loma Linda University Electronic Theses, Dissertations & Projects

Ultrasound is a widely used diagnostic tool for patients with plantar fasciitis. It provides an inexpensive and noninvasive method for quantifying the plantar fascia with accuracy levels comparable to magnetic resonance imaging (MRI). However, some researchers have criticized the lack of standardization in the ultrasound measurement process for plantar fascia thickness as it calls into question the validity of the final measures. One critical component lacking any standardization during the procedure is metatarsophalangeal (MTP) joint position as ultrasound examiners often extend the toe position during the process. This variation has made it difficult to understand the etiology of plantar fasciitis …

Gene Delivery Of Adenoviral-Tmbim6 Vector Protects The Neonatal Brain After Hypoxic-Ischemic Injury, Desislava Doycheva

Loma Linda University Electronic Theses, Dissertations & Projects

Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive oxygen species (ROS), from cytochrome P450 members (CYP) and NADPH-P450 reductases (NPR), in combination with activation of the unfolded protein response (UPR) are two major consequences of ER stress that cause oxidative damage and cell death. Herein we identified the role of Bax Inhibitor-1 (BI-1), an evolutionary conserved protein encoded by the Transmembrane Bax inhibitor Motif Containing …

The Role Of Glucocorticoid Signaling In Prostate Cancer Health Disparities, Leanne W. Burnham

Loma Linda University Electronic Theses, Dissertations & Projects

African-American men are more likely to develop aggressive prostate cancer (PCa) and die from the disease than other ethnic groups. Glucocorticoid signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. The mechanism involves glucocorticoids binding to glucocorticoid receptor (GR) and bypassing the androgen receptor (AR) signaling pathway to activate AR-target genes that promote tumor aggressiveness and therapy-resistance. This is problematic as African-American men have hypersensitive GR signaling and chronically-elevated levels of glucocorticoids linked to cumulative stressful life events. To explore the role of glucocorticoid …

Epidemiological, Environmental, And Biological Risk Factors For Gastroschisis, Arti Ketan Desai

Loma Linda University Electronic Theses, Dissertations & Projects

Gastroschisis, a congenital defect of the abdominal wall, manifests as external herniation of viscera, most commonly the fetal bowel. The worldwide prevalence of gastroschisis continues to rise, and this increase can also be seen in California with an overall birth prevalence of 2-3 per 10,000 births. While the etiology and pathogenesis of gastroschisis remains unknown, previous studies indicate several risk factors including young maternal age, nulliparity, and low maternal body mass index, in addition to environmental factors and exposure, given the increase in global prevalence with a predisposition of cases to occur in clusters, and absence of a genetic link. …