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- Keyword
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- Nuclear Medicine & Medical;; Imaging (5)
- 18F-fluorodeoxyglucose;; Bone scintigraphy;; F-18;; Fluoride-positron emission tomography;; Gallium;; Infection;; Labeled leukocytes;; Positron emission tomography;; Prosthetic joint (1)
- ACUTE ISCHEMIC-STROKE;; TISSUE-PLASMINOGEN-ACTIVATOR;; HYPERACUTE;; INTRACEREBRAL HEMORRHAGE;; DIGITAL-SUBTRACTION-ANGIOGRAPHY;; AMERICAN-HEART-ASSOCIATION;; COOPERATIVE ACUTE STROKE;; ACUTE HEMISPHERIC;; STROKE;; CEREBRAL-ARTERY SIGN;; THROMBOLYTIC THERAPY;; CT-ANGIOGRAPHY;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- ANEURYSMAL SUBARACHNOID HEMORRHAGE;; PERFUSION-CT;; CEREBRAL PERFUSION;; ACUTE STROKE;; ANGIOGRAPHY;; PARAMETERS;; VALUES;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Adolescent;; Adult;; Anisotropy;; Brain Concussion/ diagnosis/pathology;; Case-Control Studies;; Diffusion Tensor Imaging/ methods;; Female;; Glasgow Coma Scale;; Humans;; Image Interpretation (1)
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- Algorithms. Blood-Brain Barrier / *radiography. Humans. Models (1)
- Atherectomy;; calcification;; cardiovascular intervention;; clinical trial;; coronary;; ELUTING STENT IMPLANTATION;; SPEED ROTATIONAL ATHERECTOMY;; SINGLE-CENTER;; EXPERIENCE;; ANGIOGRAPHIC FOLLOW-UP;; ARTERY-DISEASE;; INTRAVASCULAR;; ULTRASOUND;; BALLOON ANGIOPLASTY;; CLINICAL-OUTCOMES;; COMPLEX LESIONS;; INTERVENTION;; Cardiac & Cardiovascular Systems (1)
- Atp7b;; Wilson’s disease;; diagnosis;; metal complex;; positron emission tomography;; radiocopper;; therapy (1)
- Brachiocephalic vein;; EC-IC bypass;; Infratemporal approach;; Internal;; maxillary artery;; CAROTID-ARTERY;; ANEURYSMS;; REVASCULARIZATION;; SURGERY;; VEIN;; DISEASE;; GRAFTS;; FOSSA;; Clinical Neurology;; Surgery (1)
- COMPUTED-TOMOGRAPHY;; OUTCOME MEASURES;; VASOSPASM;; ANGIOGRAPHY;; DEFINITION;; MANAGEMENT;; SURGERY;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Computer-Assisted / *methods. Signal-To-Noise Ratio. Stroke / *radiography. Tomography (1)
- Computer-Assisted;; Male;; Middle Aged;; Nerve Fibers (1)
- DELAYED CEREBRAL-ISCHEMIA;; DIGITAL-SUBTRACTION-ANGIOGRAPHY;; COMPUTED-TOMOGRAPHY;; VASOSPASM;; DEFINITION;; INFARCTION;; VALUES;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Diffusion tensor imaging (DTI);; chronic pain;; neuroimaging;; white matter (1)
- HUNTINGTONS-DISEASE;; HUMAN STRIATUM;; BRAIN;; DOSIMETRY;; ATROPHY;; PET;; Biotechnology & Applied Microbiology;; Medicine (1)
- Myelinated/ pathology;; Observer Variation;; Prospective Studies;; Tomography (1)
- PERFUSION COMPUTED-TOMOGRAPHY;; OUTCOME MEASURES;; CT ANGIOGRAPHY;; BEDSIDE;; MICRODIALYSIS;; CASE-FATALITY;; ACUTE STROKE;; VASOSPASM;; INFARCTION;; TRIALS;; SPECTROSCOPY;; Clinical Neurology;; Neuroimaging;; Radiology (1)
- Research & Experimental (1)
- Theoretical. Radiation Dosage. Radiographic Image Interpretation (1)
- X-Ray Computed (1)
- X-Ray Computed / *methods;; Index Medicus;; Blood-brain barrier permeability;; Patlak model;; Radiation dose reduction;; Sparse high-dose induced prior (1)
Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Radiation Absorbed Dose To The Basal Ganglia From Dopamine Transporter Radioligand F-18-Fpcit, W. Robeson, V. Dhawan, Y. L. Ma, D. Bjelke, C. Margouleff, T. Chaly, D. Eidelberg
Radiation Absorbed Dose To The Basal Ganglia From Dopamine Transporter Radioligand F-18-Fpcit, W. Robeson, V. Dhawan, Y. L. Ma, D. Bjelke, C. Margouleff, T. Chaly, D. Eidelberg
Journal Articles
Our previous dosimetry studies have demonstrated that for dopaminergic radiotracers, F-18-FDOPA and F-18-FPCIT, the urinary bladder is the critical organ. As these tracers accumulate in the basal ganglia (BG) with high affinity and long residence times, radiation dose to the BG may become significant, especially in normal control subjects. We have performed dynamic PET measurements using F-18-FPCIT in 16 normal adult subjects to determine if in fact the BG, although not a whole organ, but a well-defined substructure, receives the highest dose. Regions of interest were drawn over left and right BG structures. Resultant time-activity curves were generated and used …
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Journal Articles
Vaginal bleeding in early pregnancy is a common emergency department complaint. Point-of-care ultrasound is a useful tool to evaluate for intrauterine ectopic pregnancy. Emergency physicians performing these studies need to be cognizant of artifacts produced by ultrasound technology, as they can lead to misdiagnosis. We present two cases where mirror-image artifacts initially led to a concern for heterotopic pregnancies but were excluded on further imaging.
Internal Maxillary Artery-Middle Cerebral Artery Bypass: Infratemporal Approach For Subcranial-Intracranial (Sc-Ic) Bypass, E. Nossek, P. Costantino, M. Eisenberg, A. R. Dehdashti, A. Setton, D. J. Chalif, R. A. Ortiz, D. J. Langer
Internal Maxillary Artery-Middle Cerebral Artery Bypass: Infratemporal Approach For Subcranial-Intracranial (Sc-Ic) Bypass, E. Nossek, P. Costantino, M. Eisenberg, A. R. Dehdashti, A. Setton, D. J. Chalif, R. A. Ortiz, D. J. Langer
Journal Articles
BACKGROUND:Internal maxillary artery (IMax)-middle cerebral artery (MCA) bypass has been recently described as an alternative to cervical extracranial-intracranial bypass. This technique uses a keyhole craniectomy in the temporal fossa that requires a technically challenging end-to-side anastomosis.OBJECTIVE:To describe a lateral subtemporal craniectomy of the middle cranial fossa floor to facilitate wide exposure of the IMax to facilitate bypass.METHODS:Orbitozygomatic osteotomy is used followed by frontotemporal craniotomy and subsequently laterotemporal fossa craniectomy, reaching its medial border at a virtual line connecting the foramen rotundum and foramen ovale. The IMax was identified by using established anatomic landmarks, neuronavigation, and micro Doppler probe (Mizuho Inc. …
Pivotal Trial To Evaluate The Safety And Efficacy Of The Orbital Atherectomy System In Treating De Novo, Severely Calcified Coronary Lesions (Orbit Ii), J. W. Chambers, R. L. Feldman, S. I. Himmelstein, R. Bhatheja, A. E. Villa, K. C. Patel, J. A. Puma, P. Makam, B. D. Bertolet, G. Y. Nseir, +10 Additional Authors
Pivotal Trial To Evaluate The Safety And Efficacy Of The Orbital Atherectomy System In Treating De Novo, Severely Calcified Coronary Lesions (Orbit Ii), J. W. Chambers, R. L. Feldman, S. I. Himmelstein, R. Bhatheja, A. E. Villa, K. C. Patel, J. A. Puma, P. Makam, B. D. Bertolet, G. Y. Nseir, +10 Additional Authors
Journal Articles
Objectives The ORBIT II (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) trial evaluated the safety and efficacy of the coronary Orbital Atherectomy System (OAS) to prepare de novo, severely calcified coronary lesions for stent placement. Background Despite advances in interventional techniques, treatment of calcified coronary lesions remains a challenge. Stent placement in these lesions may result in stent underexpansion, malapposition, and procedural complications. Methods ORBIT II is a prospective, multicenter, nonblinded clinical trial that enrolled 443 consecutive patients with severely calcified coronary lesions at 49 U.S. sites from May 25, 2010, to November 26, …
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Diagnosis Of Abnormal Biliary Copper Excretion By Positron Emission Tomography With Targeting Of (64)Copper-Asialofetuin Complex In Lec Rat Model Of Wilson's Disease, R. Bahde, S. Kapoor, K. K. Bhargava, C. J. Palestro, S. Gupta
Journal Articles
Identification by molecular imaging of key processes in handling of transition state metals, such as copper (Cu), will be of considerable clinical value. For instance, the ability to diagnose Wilson's disease with molecular imaging by identifying copper excretion in an ATP7B-dependent manner will be very significant. To develop highly effective diagnostic approaches, we hypothesized that targeting of radiocopper via the asialoglycoprotein receptor will be appropriate for positron emission tomography, and examined this approach in a rat model of Wilson's disease. After complexing (64)Cu to asialofetuin we studied handling of this complex compared with (64)Cu in healthy LEA rats and diseased …
Improving Low-Dose Blood-Brain Barrier Permeability Quantification Using Sparse High-Dose Induced Prior For Patlak Model, R. Fang, K. Karlsson, T. Chen, P. C. Sanelli
Improving Low-Dose Blood-Brain Barrier Permeability Quantification Using Sparse High-Dose Induced Prior For Patlak Model, R. Fang, K. Karlsson, T. Chen, P. C. Sanelli
Journal Articles
Blood-brain barrier permeability (BBBP) measurements extracted from the perfusion computed tomography (PCT) using the Patlak model can be a valuable indicator to predict hemorrhagic transformation in patients with acute stroke. Unfortunately, the standard Patlak model based PCT requires excessive radiation exposure, which raised attention on radiation safety. Minimizing radiation dose is of high value in clinical practice but can degrade the image quality due to the introduced severe noise. The purpose of this work is to construct high quality BBBP maps from low-dose PCT data by using the brain structural similarity between different individuals and the relations between the high- …
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Appropriate Use Of Ct Perfusion Following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach, R. P. Killeen, A. Gupta, H. Delaney, C. E. Johnson, A. J. Tsiouris, M. E. Fink, H. S. Mangat, A. Z. Segal, A. I. Mushlin, P. C. Sanelli, +1 Additional Author
Journal Articles
These investigators evaluated the test characteristics of CTP in patients with SAH for detection of delayed cerebral ischemia. Ninety-seven patients were assessed with CTP for ischemia and with DSA for vasospasm. The authors concluded that positive CTP findings identified patients who should be carefully considered for induced hypertension, hypervolemia, and hemodilution and/or intra-arterial therapy while negative CTP findings are useful in guiding a no-treatment decision. BACKGROUND AND PURPOSE: In recent years CTP has been used as a complementary diagnostic tool in the evaluation of delayed cerebral ischemia and vasospasm. Our aim was to determine the test characteristics of CTP for …
White Matter Involvement In Chronic Musculoskeletal Pain, G. Lieberman, M. Shpaner, R. Watts, T. Andrews, C. G. Filippi, M. Davis, M. R. Naylor
White Matter Involvement In Chronic Musculoskeletal Pain, G. Lieberman, M. Shpaner, R. Watts, T. Andrews, C. G. Filippi, M. Davis, M. R. Naylor
Journal Articles
There is emerging evidence that chronic musculoskeletal pain is associated with anatomic and functional abnormalities in gray matter. However, little research has investigated the relationship between chronic musculoskeletal pain and white matter. In this study, we used whole-brain tract-based spatial statistics and region-of-interest analyses of diffusion tensor imaging data to demonstrate that patients with chronic musculoskeletal pain exhibit several abnormal metrics of white matter integrity compared with healthy controls. Chronic musculoskeletal pain was associated with lower fractional anisotropy in the splenium of the corpus callosum and the left cingulum adjacent to the hippocampus. Patients also had higher radial diffusivity in …
Combined Pulmonary Venous Thromboembolism And Renal Artery Thrombosis In A Patient With Non-Small Cell Lung Cancer, G. Mavani, S. Machnicki, R. Lavie
Combined Pulmonary Venous Thromboembolism And Renal Artery Thrombosis In A Patient With Non-Small Cell Lung Cancer, G. Mavani, S. Machnicki, R. Lavie
Journal Articles
No abstract provided.
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Ct Perfusion For Detection Of Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: A Systematic Review And Meta-Analysis, D. I. A. Mir, A. Gupta, A. Dunning, L. Puchi, C. L. Robinson, H. A. B. Epstein, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a significant cause of morbidity and mortality after aneurysmal SAH, leading to poor outcomes. The purpose of this study was to evaluate the usefulness of CTP in determining delayed cerebral ischemia in patients with aneurysmal SAH. MATERIALS AND METHODS: We conducted a systematic review evaluating studies that assessed CTP in patients with aneurysmal SAH for determining delayed cerebral ischemia. Studies using any of the following definitions of delayed cerebral ischemia were included in the systematic review: 1) new onset of clinical deterioration, 2) cerebral infarction identified on follow-up CT or MR imaging, and …
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Does The Location Of The Arterial Input Function Affect Quantitative Ctp In Patients With Vasospasm?, B. J. Shin, N. Anumula, S. Hurtado-Rua, P. Masi, R. Campbell, R. Spandorfer, A. Ferrone, T. Caruso, A. Gupta, P. C. Sanelli, +2 Additional Authors
Journal Articles
BACKGROUND AND PURPOSE: In recent years, there has been increasing use of CTP imaging in patients with aneurysmal SAH to evaluate for vasospasm. Given the critical role of the arterial input function for generation of accurate CTP data, several studies have evaluated the effect of varying the arterial input function location in patients with acute stroke. Our aim was to determine the effect on quantitative CTP data when the arterial input function location is distal to significant vasospasm in patients with aneurysmal SAH. MATERIALS AND METHODS: A retrospective study was conducted of patients with aneurysmal SAH admitted from 2005 to …
Nuclear Medicine And The Failed Joint Replacement: Past, Present, And Future, C. J. Palestro
Nuclear Medicine And The Failed Joint Replacement: Past, Present, And Future, C. J. Palestro
Journal Articles
Soon after the introduction of the modern prosthetic joint, it was recognized that radionuclide imaging provides useful information about these devices. The bone scan was used extensively to identify causes of prosthetic joint failure. It became apparent, however, that although sensitive, regardless of how the images were analyzed or how it was performed, the test was not specific and could not distinguish among the causes of prosthetic failure. Advances in anatomic imaging, notably cross sectional modalities, have facilitated the diagnosis of many, if not most, causes of prosthetic failure, with the important exception of infection. This has led to a …
Cost-Effectiveness Of Ct Angiography And Perfusion Imaging For Delayed Cerebral Ischemia And Vasospasm In Aneurysmal Subarachnoid Hemorrhage, P. C. Sanelli, A. Pandya, A. Z. Segal, A. Gupta, S. Hurtado-Rua, J. Ivanidze, K. Kesavabhotla, D. Mir, A. I. Mushlin, M. G. Hunink
Cost-Effectiveness Of Ct Angiography And Perfusion Imaging For Delayed Cerebral Ischemia And Vasospasm In Aneurysmal Subarachnoid Hemorrhage, P. C. Sanelli, A. Pandya, A. Z. Segal, A. Gupta, S. Hurtado-Rua, J. Ivanidze, K. Kesavabhotla, D. Mir, A. I. Mushlin, M. G. Hunink
Journal Articles
BACKGROUND AND PURPOSE: Delayed cerebral ischemia and vasospasm are significant complications following SAH leading to cerebral infarction, functional disability, and death. In recent years, CTA and CTP have been used to increase the detection of delayed cerebral ischemia and vasospasm. Our aim was to perform comparative-effectiveness and cost-effectiveness analyses evaluating CTA and CTP for delayed cerebral ischemia and vasospasm in aneurysmal SAH from a health care payer perspective. MATERIALS AND METHODS: We developed a decision model comparing CTA and CTP with transcranial Doppler sonography for detection of vasospasm and delayed cerebral ischemia in SAH. The clinical pathways were based on …
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Imaging And Treatment Of Patients With Acute Stroke: An Evidence-Based Review, P. C. Sanelli, J. B. Sykes, A. L. Ford, J. M. Lee, K. D. Vo, D. K. Hallam
Journal Articles
Evidence-based medicine has emerged as a valuable tool to guide clinical decision-making, by summarizing the best possible evidence for both diagnostic and treatment strategies. Imaging plays a critical role in the evaluation and treatment of patients with acute ischemic stroke, especially those who are being considered for thrombolytic or endovascular therapy. Time from stroke-symptom onset to treatment is a strong predictor of long-term functional outcome after stroke. Therefore, imaging and treatment decisions must occur rapidly in this setting, while minimizing unnecessary delays in treatment. The aim of this review was to summarize the best available evidence for the diagnostic and …
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Delayed Cerebral Ischemia In Aneurysmal Subarachnoid Hemorrhage: Proposal Of An Evidence-Based Combined Clinical And Imaging Reference Standard, P. C. Sanelli, S. Kishore, A. Gupta, H. Mangat, A. Rosengart, H. Kamel, A. Segal
Journal Articles
Aneurysmal subarachnoid hemorrhage is associated with high morbidity and mortality, with delayed neurologic deficits from delayed cerebral ischemia contributing to a large portion of the adverse outcomes in this patient population. There is currently no consensus reference standard for establishing the diagnosis of delayed cerebral ischemia either in the research or clinical settings, ultimately limiting strategies for preventing delayed infarction and permanent neurologic deficits. There are currently both clinical and imaging-based criteria for the diagnosis of delayed neurologic deficits and vasospasm, respectively, however, neither clinical nor angiographic assessment alone has been shown to identify patients who develop adverse outcomes from …
Potholes And Molehills: Bias In The Diagnostic Performance Of Diffusion-Tensor Imaging In Concussion, R. Watts, A. Thomas, C. G. Filippi, J. P. Nickerson, K. Freeman
Potholes And Molehills: Bias In The Diagnostic Performance Of Diffusion-Tensor Imaging In Concussion, R. Watts, A. Thomas, C. G. Filippi, J. P. Nickerson, K. Freeman
Journal Articles
PURPOSE: To investigate the extent of bias in a clinical study involving "pothole analysis" of diffusion-tensor imaging (DTI) data used to quantify white matter lesion load in diseases with a heterogeneous spatial distribution of pathologic findings, such as mild traumatic brain injury (TBI), and create a mathematical model of the bias. MATERIALS AND METHODS: Use of the same reference population to define normal findings and make comparisons with a patient group introduces bias, which potentially inflates reported diagnostic performance. In this institutional review board-approved prospective observational cohort study, DTI data were obtained in 20 patients admitted to the emergency department …