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Articles 1 - 29 of 29
Full-Text Articles in Medicine and Health Sciences
Assessing 2 D-Dimer Age-Adjustment Strategies To Optimize Computed Tomographic Use In Ed Evaluation Of Pulmonary Embolism, A. Gupta, A. S. Raja, I. K. Ip, R. Khorasani
Assessing 2 D-Dimer Age-Adjustment Strategies To Optimize Computed Tomographic Use In Ed Evaluation Of Pulmonary Embolism, A. Gupta, A. S. Raja, I. K. Ip, R. Khorasani
Journal Articles
STUDY OBJECTIVE: Validate the sensitivity and specificity of 2 age adjustment strategies for d-dimer values in identifying patients at risk for pulmonary embolism (PE) compared with traditional D-dimer cutoff value (500 ng/mL) to decrease inappropriate computed tomography pulmonary angiography (CTPA) use. METHODS: This institutional review board-approved, Health Insurance Portability and Accountability Act-compliant retrospective study included all adult emergency department patients evaluated for PE over a 32-month period (1/1/11-8/30/13). Only patients undergoing CTPA and D-dimer testing were included. We used a validated natural language processing algorithm to parse CTPA radiology reports and determine the presence of acute PE. Outcome measures were …
Incidence And Predictors Of Acute Psychological Distress And Dissociation After Motor Vehicle Collision: A Cross-Sectional Study, G. C. Lewis, T. F. Platts-Mills, I. Liberzon, E. Bair, R. Swor, N. Rathlev, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors
Incidence And Predictors Of Acute Psychological Distress And Dissociation After Motor Vehicle Collision: A Cross-Sectional Study, G. C. Lewis, T. F. Platts-Mills, I. Liberzon, E. Bair, R. Swor, N. Rathlev, D. Lee, R. Domeier, P. Hendry, S. A. Mclean, +2 Additional Authors
Journal Articles
Objective: We examined the incidence and predictors of peritraumatic distress and dissociation after one of the most common forms of civilian trauma exposure: motor vehicle collision (MVC). Method: In this study, patients presenting to the emergency department after MVCs who were without serious injury and discharged to home after evaluation (n = 935) completed an emergency department interview evaluating sociodemographic, collision-related, and psychological characteristics. Results: The incidence and predictors of distress (Peritraumatic Distress Inventory score 23) and dissociation (Michigan Critical Events Perception Scale score >3) were assessed. Distress was present in 355 of 935 patients (38%), and dissociation was present …
Sideline Coverage: When To Get Radiographs? A Review Of Clinical Decision Tools, S. J. Gould, D. A. Cardone, J. Munyak, P. J. Underwood, S. A. Gould
Sideline Coverage: When To Get Radiographs? A Review Of Clinical Decision Tools, S. J. Gould, D. A. Cardone, J. Munyak, P. J. Underwood, S. A. Gould
Journal Articles
CONTEXT: Sidelines coverage presents unique challenges in the evaluation of injured athletes. Health care providers may be confronted with the question of when to obtain radiographs following an injury. Given that most sidelines coverage occurs outside the elite level, radiographs are not readily available at the time of injury, and the decision of when to send a player for radiographs must be made based on physical examination. Clinical tools have been developed to aid in identifying injuries that are likely to result in radiographically important fractures or dislocations. EVIDENCE ACQUISITION: A search for the keywords x-ray and decision rule along …
Effect Of Clinical Decision Support On Documented Guideline Adherence For Head Ct In Emergency Department Patients With Mild Traumatic Brain Injury, A. Gupta, I. K. Ip, A. S. Raja, J. E. Andruchow, A. Sodickson, R. Khorasani
Effect Of Clinical Decision Support On Documented Guideline Adherence For Head Ct In Emergency Department Patients With Mild Traumatic Brain Injury, A. Gupta, I. K. Ip, A. S. Raja, J. E. Andruchow, A. Sodickson, R. Khorasani
Journal Articles
Imaging utilization in emergency departments (EDs) has increased significantly. More than half of the 1.2 million patients with mild traumatic brain injury (MTBI) presenting to US EDs receive head CT. While evidence-based guidelines can help emergency clinicians decide whether to obtain head CT in these patients, adoption of these guidelines has been highly variable. Promulgation of imaging efficiency guidelines by the National Quality Forum has intensified the need for performance reporting, but measuring adherence to these imaging guidelines currently requires labor-intensive and potentially inaccurate manual chart review. We implemented clinical decision support (CDS) based on published evidence to guide emergency …
Examining Clinical Decision Support Integrity: Is Clinician Self-Reported Data Entry Accurate?, A. Gupta, A. S. Raja, R. Khorasani
Examining Clinical Decision Support Integrity: Is Clinician Self-Reported Data Entry Accurate?, A. Gupta, A. S. Raja, R. Khorasani
Journal Articles
The aim of this study was to assess the accuracy of clinician-entered data in imaging clinical decision support (CDS). We used CDS-guided CT angiography (CTA) for pulmonary embolus (PE) in the emergency department as a case example because it required clinician entry of d-dimer results which could be unambiguously compared with actual laboratory values. Of 1296 patients with CTA orders for suspected PE during 2011, 1175 (90.7%) had accurate d-dimer values entered. In 55 orders (4.2%), incorrectly entered data shielded clinicians from intrusive computer alerts, resulting in potential CTA overuse. Remaining data entry errors did not affect user workflow. We …
The Hmgb1/Rage Inflammatory Pathway Promotes Pancreatic Tumor Growth By Regulating Mitochondrial Bioenergetics, R. Kang, D. Tang, N. E. Schapiro, T. Loux, K. M. Livesey, T. R. Billiar, H. Wang, B. Van Houten, M. T. Lotze, H. J. Zeh
The Hmgb1/Rage Inflammatory Pathway Promotes Pancreatic Tumor Growth By Regulating Mitochondrial Bioenergetics, R. Kang, D. Tang, N. E. Schapiro, T. Loux, K. M. Livesey, T. R. Billiar, H. Wang, B. Van Houten, M. T. Lotze, H. J. Zeh
Journal Articles
Tumor cells require increased adenosine triphosphate (ATP) to support anabolism and proliferation. The precise mechanisms regulating this process in tumor cells are unknown. Here, we show that the receptor for advanced glycation endproducts (RAGE) and one of its primary ligands, high-mobility group box 1 (HMGB1), are required for optimal mitochondrial function within tumors. We found that RAGE is present in the mitochondria of cultured tumor cells as well as primary tumors. RAGE and HMGB1 coordinately enhanced tumor cell mitochondrial complex I activity, ATP production, tumor cell proliferation and migration. Lack of RAGE or inhibition of HMGB1 release diminished ATP production …
Middle Cerebral Artery Arrow Sign, Z. D. Levy, R. E. Temes, A. R. Dehdashti
Middle Cerebral Artery Arrow Sign, Z. D. Levy, R. E. Temes, A. R. Dehdashti
Journal Articles
No abstract provided.
Hmgb1-Dna Complex-Induced Autophagy Limits Aim2 Inflammasome Activation Through Rage, L. Y. Liu, M. H. Yang, R. Kang, Y. P. Dai, X. J. Sun, X. L. Li, J. H. Li, H. C. Wang, L. Z. Cao, D. L. Tang, +3 Additional Authors
Hmgb1-Dna Complex-Induced Autophagy Limits Aim2 Inflammasome Activation Through Rage, L. Y. Liu, M. H. Yang, R. Kang, Y. P. Dai, X. J. Sun, X. L. Li, J. H. Li, H. C. Wang, L. Z. Cao, D. L. Tang, +3 Additional Authors
Journal Articles
High mobility group box 1 (HMGB1) is a prototype damage-associated molecular pattern (DAMP) that can induce inflammatory and immune responses alone as well as in combination with other molecules such as DNA. However, the intricate molecular mechanisms underlying HMGB1-DNA complex-mediated innate immune response remains largely elusive. In this study, we demonstrated that HMGB1-DNA complex initially induced absent in melanoma 2 (AIM2)-dependent inflammasome activation, and promoted rapid release of inflammasome-dependent early proinflammatory cytokines such as interleukin 10 (IL-1 beta). Subsequently, HMGB1 - DNA complex stimulated an ATG5-dependent cellular degradation process, autophagy, which was paralleled by a cessation of AIM2 inflammasome activation …
Molecular Mechanism And Therapeutic Modulation Of High Mobility Group Box 1 Release And Action: An Updated Review, B. Lu, C. Wang, M. Wang, W. Li, F. P. Chen, K. J. Tracey, H. C. Wang
Molecular Mechanism And Therapeutic Modulation Of High Mobility Group Box 1 Release And Action: An Updated Review, B. Lu, C. Wang, M. Wang, W. Li, F. P. Chen, K. J. Tracey, H. C. Wang
Journal Articles
High mobility group box 1 (HMGB1) is an evolutionarily conserved protein, and is constitutively expressed in virtually all types of cells. Infection and injury converge on common inflammatory responses that are mediated by HMGB1 secreted from immunologically activated immune cells or passively released from pathologically damaged cells. Herein we review the emerging molecular mechanisms underlying the regulation of pathogen-associated molecular patterns (PAMPs)-induced HMGB1 secretion, and summarize many HMGB1-targeting therapeutic strategies for the treatment of infection- and injury-elicited inflammatory diseases. It may well be possible to develop strategies that specifically attenuate damage-associated molecular patterns (DAMPs)-mediated inflammatory responses without compromising the PAMPs-mediated …
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Mirror Image Artifact Mimicking Heterotopic Pregnancy On Transvaginal Ultrasound: Case Series, R. Malhotra, R. M. Bramante, M. Radomski, M. Nelson
Journal Articles
Vaginal bleeding in early pregnancy is a common emergency department complaint. Point-of-care ultrasound is a useful tool to evaluate for intrauterine ectopic pregnancy. Emergency physicians performing these studies need to be cognizant of artifacts produced by ultrasound technology, as they can lead to misdiagnosis. We present two cases where mirror-image artifacts initially led to a concern for heterotopic pregnancies but were excluded on further imaging.
Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release And Limits Acute Pancreatitis In Mice, R. Kang, Q. Zhang, W. Hou, Z. Yan, R. Chen, J. Bonaroti, P. Bansal, T. R. Billiar, A. Tsung, Q. Wang, D. L. Bartlett, D. C. Whitcomb, E. B. Chang, X. Zhu, H. Wang, B. Lu, K. J. Tracey, L. Cao, X. G. Fan, M. T. Lotze, H. J., 3rd Zeh, D. Tang
Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release And Limits Acute Pancreatitis In Mice, R. Kang, Q. Zhang, W. Hou, Z. Yan, R. Chen, J. Bonaroti, P. Bansal, T. R. Billiar, A. Tsung, Q. Wang, D. L. Bartlett, D. C. Whitcomb, E. B. Chang, X. Zhu, H. Wang, B. Lu, K. J. Tracey, L. Cao, X. G. Fan, M. T. Lotze, H. J., 3rd Zeh, D. Tang
Journal Articles
BACKGROUND & AIMS: High mobility group box 1 (HMGB1) is an abundant protein that regulates chromosome architecture and also functions as a damage-associated molecular pattern molecule. Little is known about its intracellular roles in response to tissue injury or during subsequent local and systemic inflammatory responses. We investigated the function of Hmgb1 in mice after induction of acute pancreatitis. METHODS: We utilized a Cre/LoxP system to create mice with pancreas-specific disruption in Hmbg1 (Pdx1-Cre; HMGB1(flox/flox) mice). Acute pancreatitis was induced in these mice (HMGB1(flox/flox) mice served as controls) after injection of l-arginine or cerulein. Pancreatic tissues and acinar cells were …
Incidence And Predictors Of Neck And Widespread Pain After Motor Vehicle Collision Among Us Litigants And Nonlitigants, S. A. Mclean, J. C. Ulirsch, G. D. Slade, A. C. Soward, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, E. Bair, +3 Additional Authors
Incidence And Predictors Of Neck And Widespread Pain After Motor Vehicle Collision Among Us Litigants And Nonlitigants, S. A. Mclean, J. C. Ulirsch, G. D. Slade, A. C. Soward, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, E. Bair, +3 Additional Authors
Journal Articles
Debate continues regarding the influence of litigation on pain outcomes after motor vehicle collision (MVC). In this study we enrolled European Americans presenting to the emergency department (ED) in the hours after MVC (n = 948). Six weeks later, participants were interviewed regarding pain symptoms and asked about their participation in MVC-related litigation. The incidence and predictors of neck pain and widespread pain 6 weeks after MVC were compared among those engaged in litigation (litigants) and those not engaged in litigation (nonlitigants). Among the 859 of 948 (91%) participants completing 6-week follow-up, 711 of 849 (83%) were nonlitigants. Compared to …
A Consensus Parameter For The Evaluation And Management Of Angioedema In The Emergency Department, J. J. Moellman, J. A. Bernstein, C. Lindsell, A. Banerji, P. J. Busse, C. A., Jr. Camargo, S. P. Collins, R. L. Campbell, S. Schneider, R. Sinert, +10 Additional Authors
A Consensus Parameter For The Evaluation And Management Of Angioedema In The Emergency Department, J. J. Moellman, J. A. Bernstein, C. Lindsell, A. Banerji, P. J. Busse, C. A., Jr. Camargo, S. P. Collins, R. L. Campbell, S. Schneider, R. Sinert, +10 Additional Authors
Journal Articles
Despite its relatively common occurrence and life-threatening potential, the management of angioedema in the emergency department (ED) is lacking in terms of a structured approach. It is paramount to distinguish the different etiologies of angioedema from one another and more specifically differentiate histaminergic-mediated angioedema from bradykinin-mediated angioedema, especially in lieu of the more novel treatments that have recently become available for bradykinin-mediated angioedema. With this background in mind, this consensus parameter for the evaluation and management of angioedema attempts to provide a working framework for emergency physicians (EPs) in approaching the patient with angioedema in terms of diagnosis and management …
Case Report: Transient Small Bowel Intussusception Presenting As Right Lower Quadrant Pain In A 6-Year-Old Male, M. J. Nelson, T. Paterson, C. Raio
Case Report: Transient Small Bowel Intussusception Presenting As Right Lower Quadrant Pain In A 6-Year-Old Male, M. J. Nelson, T. Paterson, C. Raio
Journal Articles
In children presenting to the emergency room with right lower quadrant pain, ultrasound is the preferred initial modality. In our patient, a 6-year-old male with a sudden onset of severe right lower quadrant pain, the differential is broad, including appendicitis and intussusception. In order to narrow our differential and secure the diagnosis, our first modality was ultrasonography. With the increased use of point-of-care ultrasound in the emergency department, the diagnosis of appendicitis and ileo-colic intussusception has been made more frequently. In addition, other entities such as transient small bowel intussusception may be identified. As in our case, obstruction secondary to …
Hmgb1 In Health And Disease, R. Kang, R. C. Chen, Q. H. Zhang, W. Hou, S. Wu, X. G. Fan, Z. W. Yan, X. F. Sun, H. C. Wang, D. L. Tang, +8 Additional Authors
Hmgb1 In Health And Disease, R. Kang, R. C. Chen, Q. H. Zhang, W. Hou, S. Wu, X. G. Fan, Z. W. Yan, X. F. Sun, H. C. Wang, D. L. Tang, +8 Additional Authors
Journal Articles
Complex genetic and physiological variations as well as environmental factors that drive emergence of chromosomal instability, development of unscheduled cell death, skewed differentiation, and altered metabolism are central to the pathogenesis of human diseases and disorders. Understanding the molecular bases for these processes is important for the development of new diagnostic biomarkers, and for identifying new therapeutic targets. In 1973, a group of non-histone nuclear proteins with high electrophoretic mobility was discovered and termed high-mobility group (HMG) proteins. The HMG proteins include three superfamilies termed HMGB, HMGN, and HMGA. High-mobility group box 1 (HMGB1), the most abundant and well-studied HMG …
Gender Differences In Acute And Chronic Pain In The Emergency Department: Results Of The 2014 Academic Emergency Medicine Consensus Conference Pain Section, P. I. Musey, S. D. Linnstaedt, T. F. Platts-Mills, J. R. Miner, A. V. Bortsov, D. C. Lee, C. S. Nam, R. G. Patel, R. B. Fillingim, S. A. Mclean, +12 Additional Authors
Gender Differences In Acute And Chronic Pain In The Emergency Department: Results Of The 2014 Academic Emergency Medicine Consensus Conference Pain Section, P. I. Musey, S. D. Linnstaedt, T. F. Platts-Mills, J. R. Miner, A. V. Bortsov, D. C. Lee, C. S. Nam, R. G. Patel, R. B. Fillingim, S. A. Mclean, +12 Additional Authors
Journal Articles
Pain is a leading public health problem in the United States, with an annual economic burden of more than $630 billion, and is one of the most common reasons that individuals seek emergency department (ED) care. There is a paucity of data regarding sex differences in the assessment and treatment of acute and chronic pain conditions in the ED. The Academic Emergency Medicine consensus conference convened in Dallas, Texas, in May 2014 to develop a research agenda to address this issue among others related to sex differences in the ED. Prior to the conference, experts and stakeholders from emergency medicine …
The Use Of Decision Support To Measure Documented Adherence To A National Imaging Quality Measure, A. S. Raja, A. Gupta, I. K. Ip, A. M. Mills, R. Khorasani
The Use Of Decision Support To Measure Documented Adherence To A National Imaging Quality Measure, A. S. Raja, A. Gupta, I. K. Ip, A. M. Mills, R. Khorasani
Journal Articles
RATIONALE AND OBJECTIVES: Present methods for measuring adherence to national imaging quality measures often require a resource-intensive chart review. Computerized decision support systems may allow for automated capture of these data. We sought to determine the feasibility of measuring adherence to a national quality measure (NQM) regarding computed tomography pulmonary angiograms (CTPAs) for pulmonary embolism using measure-targeted clinical decision support and whether the associated increased burden of data captured required by this system would affect the use and yield of CTs. MATERIALS AND METHODS: This institutional review board-approved prospective cohort study enrolled patients from September 1, 2009, through November 30, …
No Man Is An Island: Living In A Disadvantaged Neighborhood Influences Chronic Pain Development After Motor Vehicle Collision, J. C. Ulirsch, M. A. Weaver, A. V. Bortsov, A. C. Soward, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, S. A. Mclean, +2 Additional Authors
No Man Is An Island: Living In A Disadvantaged Neighborhood Influences Chronic Pain Development After Motor Vehicle Collision, J. C. Ulirsch, M. A. Weaver, A. V. Bortsov, A. C. Soward, R. A. Swor, D. A. Peak, J. S. Jones, N. K. Rathlev, D. C. Lee, S. A. Mclean, +2 Additional Authors
Journal Articles
Living in a lower socioeconomic status neighborhood has been shown to alter stress system function and is associated with a number of adverse health outcomes, but its influence on musculoskeletal pain (MSP) outcomes after traumatic stress exposures such as motor vehicle collision (MVC) has not been assessed. We performed a multicenter, prospective study that enrolled 948 European-American individuals within 24 hours of MVC who were discharged home after emergency department evaluation. Follow-up evaluations were completed via telephone or Internet survey 6 weeks, 6 months, and 1 year after MVC on 91%, 89%, and 91% of participants, respectively. A robust aggregate …
Targeting Hmgb1 In The Treatment Of Sepsis, H. C. Wang, M. F. Ward, A. E. Sama
Targeting Hmgb1 In The Treatment Of Sepsis, H. C. Wang, M. F. Ward, A. E. Sama
Journal Articles
Introduction: Sepsis refers to the host's deleterious and non-resolving systemic inflammatory response to microbial infections and represents the leading cause of death in the intensive care unit. The pathogenesis of sepsis is complex, but partly mediated by a newly identified alarmin molecule, the high mobility group box 1 (HMGB1). Areas covered: Here we review the evidence that support extracellular HMGB1 as a late mediator of experimental sepsis with a wider therapeutic window and discuss the therapeutic potential of HMGB1-neutralizing antibodies and small molecule inhibitors (herbal components) in experimental sepsis. Expert opinion: It will be important to evaluate the efficacy of …
Patients In A Private Hospital In India Leave The Emergency Department Against Medical Advice For Financial Reasons, S. Naderi, J. R. Acerra, K. Bailey, P. Mukherji, T. Taraphdar, T. Mukherjee, A. Pal, M. F. Ward, K. Miele, M. Mathias, R. Tan, M. Kline, K. Alagappan, R. Silverman
Patients In A Private Hospital In India Leave The Emergency Department Against Medical Advice For Financial Reasons, S. Naderi, J. R. Acerra, K. Bailey, P. Mukherji, T. Taraphdar, T. Mukherjee, A. Pal, M. F. Ward, K. Miele, M. Mathias, R. Tan, M. Kline, K. Alagappan, R. Silverman
Journal Articles
BACKGROUND: Some reports indicate financial concerns as a factor affecting ED patients leaving the acute care setting against medical advice (AMA). In India, no person is supposed to be denied urgent care because of inability to pay. Since a large proportion of the Indian health care system is financed by out-of-pocket expenses, we investigate the role of financial constraints for ED patients at a private hospital in India in leaving AMA. METHODS: A prospective ED-based cross-sectional survey of patients leaving AMA was conducted at a private hospital in India from 1 October 2010 to 31 December 2010. Descriptive statistics and …
Pkm2 Regulates The Warburg Effect And Promotes Hmgb1 Release In Sepsis, L. C. Yang, M. Xie, M. H. Yang, Y. Yu, S. Zhu, M. T. Lotze, T. R. Billiar, H. C. Wang, L. Z. Cao, D. L. Tang, +2 Additional Authors
Pkm2 Regulates The Warburg Effect And Promotes Hmgb1 Release In Sepsis, L. C. Yang, M. Xie, M. H. Yang, Y. Yu, S. Zhu, M. T. Lotze, T. R. Billiar, H. C. Wang, L. Z. Cao, D. L. Tang, +2 Additional Authors
Journal Articles
Increasing evidence suggests the important role of metabolic reprogramming in the regulation of the innate inflammatory response, but the underlying mechanism remains unclear. Here we provide evidence to support a novel role for the pyruvate kinase M2 (PKM2)-mediated Warburg effect, namely aerobic glycolysis, in the regulation of high-mobility group box 1 (HMGB1) release. PKM2 interacts with hypoxia-inducible factor 1 alpha (HIF1 alpha) and activates the HIF-1 alpha-dependent transcription of enzymes necessary for aerobic glycolysis in macrophages. Knockdown of PKM2, HIF1 alpha and glycolysis-related genes uniformly decreases lactate production and HMGB1 release. Similarly, a potential PKM2 inhibitor, shikonin, reduces serum lactate …
Intraperitoneal Administration Of Fetuin-A Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Failure In Mouse, P. Zhang, H. Shen, J. L. Huang, H. C. Wang, B. X. Zhang, R. R. Zhou, B. Y. Zhong, X. G. Fan
Intraperitoneal Administration Of Fetuin-A Attenuates D-Galactosamine/Lipopolysaccharide-Induced Liver Failure In Mouse, P. Zhang, H. Shen, J. L. Huang, H. C. Wang, B. X. Zhang, R. R. Zhou, B. Y. Zhong, X. G. Fan
Journal Articles
Fulminant hepatic failure (FHF) is a devastating syndrome, which sometimes results in death or liver transplantation, in which inflammation would aggravate the development of fetuin-A which would act as an anti-inflammatory factor and may be an available approach to attenuate FHF. The purpose of this study was to investigate the effects of fetuin-A on d-galactosamine/lipopolysaccharide (d-GalN/LPS)-induced liver failure in mice. A mouse model of FHF induced by d-GalN/LPS was established and fetuin-A was injected intraperitoneally prior to d-GalN/LPS treatment. At different time points after d-GalN/LPS intervention, serum TNF-alpha and IL-6 levels were measured by ELISA. Fetuin-A mRNA and protein expression …
Inhibition Of Extracellular Hmgb1 Attenuates Hyperoxia-Induced Inflammatory Acute Lung Injury, M. Entezari, M. Javdan, D. J. Antoine, D. M. Morrow, R. A. Sitapara, V. Patel, M. Wang, L. Sharma, H. Wang, L. L. Mantell, +7 Additional Authors
Inhibition Of Extracellular Hmgb1 Attenuates Hyperoxia-Induced Inflammatory Acute Lung Injury, M. Entezari, M. Javdan, D. J. Antoine, D. M. Morrow, R. A. Sitapara, V. Patel, M. Wang, L. Sharma, H. Wang, L. L. Mantell, +7 Additional Authors
Journal Articles
Prolonged exposure to hyperoxia results in acute lung injury (ALI), accompanied by a significant elevation in the levels of proinflammatory cytokines and leukocyte infiltration in the lungs. However, the mechanisms underlying hyperoxia-induced proinflammatory ALI remain to be elucidated. In this study, we investigated the role of the proinflammatory cytokine high mobility group box protein 1 (HMGB1) in hyperoxic inflammatory lung injury, using an adult mouse model. The exposure of C57BL/6 mice to >/=99% O2 (hyperoxia) significantly increased the accumulation of HMGB1 in the bronchoalveolar lavage fluids (BALF) prior to the onset of severe inflammatory lung injury. In the airways of …
Comment On "Effectiveness Of Naltrexone In The Prevention Of Delayed Respiratory Arrest In Opioid-Naive Methadone-Intoxicated Patients'', B. D. Kessler, R. S. Hoffman
Comment On "Effectiveness Of Naltrexone In The Prevention Of Delayed Respiratory Arrest In Opioid-Naive Methadone-Intoxicated Patients'', B. D. Kessler, R. S. Hoffman
Journal Articles
No abstract provided.
Arthroscopic Treatment Of Bucket-Handle Labral Tear And Acetabular Fracture, K. J. Stabile, J. A. Neumann, S. Mannava, E. A. Howse, A. J. Stubbs
Arthroscopic Treatment Of Bucket-Handle Labral Tear And Acetabular Fracture, K. J. Stabile, J. A. Neumann, S. Mannava, E. A. Howse, A. J. Stubbs
Journal Articles
Traumatic hip dislocations are associated with chondral and labral pathology as well as loose bodies that can be incarcerated in the joint. These types of injury often lead to traumatic arthritis. In some cases an osseo-labral fragment may become incarcerated in the joint that is not readily visualized preoperatively. In place of open surgery, hip arthroscopy permits a technique to remove loose bodies and repair labral tears to restore joint congruity and achieve fracture reduction and fixation.
Arthroscopic Hip Labral Repair: The Iberian Suture Technique, A. J. Stubbs, J. S. Andersen, S. Mannava, B. M. Wooster, E. A. Howse, S. B. Winter
Arthroscopic Hip Labral Repair: The Iberian Suture Technique, A. J. Stubbs, J. S. Andersen, S. Mannava, B. M. Wooster, E. A. Howse, S. B. Winter
Journal Articles
Arthroscopic hip labral repair has beneficial short-term outcomes; however, debate exists regarding ideal surgical labral repair technique. This technical note presents an arthroscopic repair technique that uses intrasubstance labral suture passage to restore the chondrolabral interface. This "Iberian suture technique" allows for an anatomic repair while posing minimal risk of damage to the labral and chondral tissues.
Bilateral Hydronephrosis And Cystitis Resulting From, V. H. Tran, M. Nelson, J. Nogar, R. M. Bramante
Bilateral Hydronephrosis And Cystitis Resulting From, V. H. Tran, M. Nelson, J. Nogar, R. M. Bramante
Journal Articles
Ketamine associated urinary dysfunction has become increasingly more common worldwide. Point-of-care ultrasound (POCUS) is an established modality for diagnosing hydronephrosis in the emergency department. We describe a case of a young male ketamine abuser with severe urinary urgency and frequency in which POCUS performed by the emergency physician demonstrated bilateral hydronephrosis and a focally thickened irregular shaped bladder. Emergency physicians should consider using POCUS evaluate for hydronephrosis and bladder changes in ketamine abusers with lower urinary tract symptoms. The mainstay of treatment is discontinuing ketamine abuse.
Should Osteopathic Students Applying To Allopathic Emergency Medicine Programs Take The Usmle Exam?, M. Weizberg, D. Kass, A. Hussains, J. Cohen, B. Hahn
Should Osteopathic Students Applying To Allopathic Emergency Medicine Programs Take The Usmle Exam?, M. Weizberg, D. Kass, A. Hussains, J. Cohen, B. Hahn
Journal Articles
INTRODUCTION: Board scores are an important aspect of an emergency medicine (EM) residency application. Residency directors use these standardized tests to objectively evaluate an applicant's potential and help decide whether to interview a candidate. While allopathic (MD) students take the United States Medical Licensing Examination (USMLE), osteopathic (DO) students take the Comprehensive Osteopathic Medical Licensing Examination (COMLEX). It is difficult to compare these scores. Previous literature proposed an equation to predict USMLE based on COMLEX. Recent analyses suggested this may no longer be accurate. DO students applying to allopathic programs frequently ask whether they should take USMLE to overcome this …
Effect Of Pain Location And Duration On Life Function In The Year After Motor Vehicle Collision, A. V. Bortsov, T. F. Platts-Mills, D. A. Peak, J. S. Jones, R. A. Swor, D. C. Lee, N. K. Rathlev, P. L. Hendry, R. B. Fillingim, S. A. Mclean, +1 Additional Author
Effect Of Pain Location And Duration On Life Function In The Year After Motor Vehicle Collision, A. V. Bortsov, T. F. Platts-Mills, D. A. Peak, J. S. Jones, R. A. Swor, D. C. Lee, N. K. Rathlev, P. L. Hendry, R. B. Fillingim, S. A. Mclean, +1 Additional Author
Journal Articles
Persistent musculoskeletal pain is common after motor vehicle collision (MVC) and often results in substantial disability. The objective of this study was to identify distributions of post-MVC pain that most interfere with specific life functions and that have the greatest interference with aggregate life function. Study data were obtained from a prospective longitudinal multicenter emergency department-based cohort of 948 European Americans experiencing MVC. Overall pain (0-10 numeric rating scale [NRS]), pain in each of 20 body regions (0-10 NRS), and pain interference (Brief Pain Inventory, 0-10 NRS) were assessed 6 weeks, 6 months, and 1 year after MVC. After adjustment …