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Full-Text Articles in Medicine and Health Sciences
Oral Glucose Challenge Impairs Skeletal Muscle Microvascular Blood Flow In Healthy People, Ryan D. Russell, Donghua Hu, Timothy Greenaway, James E. Sharman, Stephen Rattigan, Stephen M. Richards, Michelle A. Keske
Oral Glucose Challenge Impairs Skeletal Muscle Microvascular Blood Flow In Healthy People, Ryan D. Russell, Donghua Hu, Timothy Greenaway, James E. Sharman, Stephen Rattigan, Stephen M. Richards, Michelle A. Keske
Health & Human Performance Faculty Publications and Presentations
Skeletal muscle microvascular (capillary) blood flow increases in the postprandial state or during insulin infusion due to dilation of precapillary arterioles to augment glucose disposal. This effect occurs independently of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict precapillary arterioles, and causes muscle insulin resistance in vivo. We hypothesized that acute hyperglycemia impairs postprandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans. Fifteen healthy people (5 F/10 M) underwent an oral glucose challenge (OGC, 50 g glucose) and a mixed-meal challenge (MMC) on two separate occasions (randomized, crossover design). …