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Full-Text Articles in Medicine and Health Sciences
Social Determinants Of Health And Uptake Of Colorectal Cancer Screening In Canada, Seth F. Kadish
Social Determinants Of Health And Uptake Of Colorectal Cancer Screening In Canada, Seth F. Kadish
Electronic Thesis and Dissertation Repository
Colorectal cancer (CRC) screening uptake may be associated with social determinants of health and could indicate potential barriers to health service access. The goal of this thesis was to evaluate the association of social determinants with CRC screening in screen-eligible adults. We used Andersen’s Behavioural Model of Health Service Utilization and the PROGRESS-Plus Framework to conceptualize potential social determinants. Our first study was a systematic review of peer-reviewed Canadian studies, and the second was a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging (CLSA). The systematic review found lower uptake was associated with non-White ethno-racial identity, less …
Uptake Of Colorectal Cancer Screening Tests By Ontario Physicians., Owen Litwin
Uptake Of Colorectal Cancer Screening Tests By Ontario Physicians., Owen Litwin
Electronic Thesis and Dissertation Repository
This population-based study used administrative healthcare data to examine the uptake of tests recommended for colorectal cancer screening by eligible Ontario physicians and non-physicians, and to examine if testing of primary care physicians is associated with greater testing in their patients. Physicians (n=11,434) were matched 1:4 to non-physicians (n=45,736) on age, sex, and geographic location as of April 21, 2016. Uptake of colorectal tests was similar in physicians (67.9%, 95% CI, 67.0–68.7%) and non-physicians (66.6%, 95% CI, 66.2–67.1%). Physicians were more likely than non-physicians to undergo colonoscopy and less likely to undergo fecal occult blood testing. Uptake of colorectal tests …
Identifying And Targeting Cancer Stem Cells In Colorectal Cancer, Amber Harnett
Identifying And Targeting Cancer Stem Cells In Colorectal Cancer, Amber Harnett
Electronic Thesis and Dissertation Repository
The cancer stem cell hypothesis posits that cancer stem cells (CSCs) are the driving force behind tumour progression and metastasis, making them ideal therapeutic targets. Previous research identified Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a marker of CSCs in colorectal cancer (CRC). However, it is not known whether more than one CSC population exists in CRC. Identifying and targeting CSCs in CRC is important for effective treatment of cancer patients. Here, I show that Keratin-19 (K19) labels intestinal CSCs in mouse tumours that recapitulate the early stages of CRC. Moreover, selective ablation of Lgr5 has no effect on tumour …