Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Utilizing Quantitative Fluorescence Microscopy To Study Oncogenesis, Ellen W. Hatch
Utilizing Quantitative Fluorescence Microscopy To Study Oncogenesis, Ellen W. Hatch
Biomedical Sciences ETDs
Quantitative fluorescence microscopy is a highly technical, swiftly evolving field of methodologies that are uniquely able to probe the nano-scale biological environment. With these optimized, advanced technologies available, scientists and medical providers are equipped to illuminate a plethora of puzzles in science and medicine through the multiplexing and high spatiotemporal resolution offered. Here I first exploit these capabilities to study a rare cancer with multiplex immunohistofluorescence (IHF) to confirm cell type and undocumented protein expression that may have implications for our understanding of the biology of mast cells and the potential efficacy of treatment and symptom management in mast cell …
Evaluation Of The Epidermal Growth Factor Receptor Signaling Pathway As A Therapeutic Target In Human Papillomavirus-Associated Disease, Anastacia Griego
Evaluation Of The Epidermal Growth Factor Receptor Signaling Pathway As A Therapeutic Target In Human Papillomavirus-Associated Disease, Anastacia Griego
Biomedical Sciences ETDs
Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. They are responsible for >99% of all cervical cancers as well as subsets of other anogenital cancers. HPVs are also the causative agents of a growing number of head and neck cancers. As such, they present a significant health problem both in the U.S. and developing countries. Much is still unknown regarding the factors underlying progression from HPV infection to cancer or maintenance of viral oncoprotein expression following oncogenic transformation. Previous studies reported significant interplay between the epidermal growth factor (EGFR) pathway and HPV oncoproteins. HPV oncoproteins E5, E6, …