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Articles 31 - 45 of 45
Full-Text Articles in Medicine and Health Sciences
Optical Coherence Tomographic Angiography Shows Reduced Deep Capillary Flow In Paracentral Acute Middle Maculopathy, K. K. Dansingani, M. Inoue, M. Engelbert, K. B. Freund
Optical Coherence Tomographic Angiography Shows Reduced Deep Capillary Flow In Paracentral Acute Middle Maculopathy, K. K. Dansingani, M. Inoue, M. Engelbert, K. B. Freund
Journal Articles
IntroductionParacentral acute middle maculopathy (PAMM) has been described as an ischemic lesion of the middle retinal layers with a characteristic lamellar hyper-reflective placoid appearance in the acute phase and thinning of the involved retinal layers in the chronic phase. Optical coherence tomographic angiography (OCTA) is a novel and non-invasive technique for imaging retinal capillary vasculature with en face segmentation capabilities.MethodCase series. We describe two patients with PAMM who underwent clinical examination and multimodal imaging including OCTA.ResultsIn the first patient, who presented with PAMM secondary to acute cilioretinal artery occlusion, OCTA demonstrated reduction in flow in the deep capillary plexus (DCP). …
En Face Oct Angiography Demonstrates Flow In Early Type 3 Neovascularization (Retinal Angiomatous Proliferation), K. K. Dansingani, J. Naysan, K. B. Freund
En Face Oct Angiography Demonstrates Flow In Early Type 3 Neovascularization (Retinal Angiomatous Proliferation), K. K. Dansingani, J. Naysan, K. B. Freund
Journal Articles
INTRODUCTION: The characteristics of type 3 neovascularization (NV), also known as retinal angiomatous proliferation, have been well described clinically, as well as with fluorescein angiography (FA), indocyanine green angiography, and optical coherence tomography (OCT). OCT angiography (OCT-A) is a novel and non-invasive technique for imaging retinal microvasculature by detecting changes, with respect to time, in reflectivity related to blood flow. METHOD: In this case series, we describe two patients who presented with type 3 NV and underwent clinical examination and multimodal imaging, including OCT-A. RESULTS: In the first patient, OCT-A demonstrated flow within two separate lesions in the same eye, …
Image Artifacts In Optical Coherence Tomography Angiography, R. F. Spaide, J. G. Fujimoto, N. K. Waheed
Image Artifacts In Optical Coherence Tomography Angiography, R. F. Spaide, J. G. Fujimoto, N. K. Waheed
Journal Articles
PURPOSE: To describe image artifacts of optical coherence tomography (OCT) angiography and their underlying causative mechanisms. To establish a common vocabulary for the artifacts observed. METHODS: The methods by which OCT angiography images are acquired, generated, and displayed are reviewed as are the mechanisms by which each or all of these methods can produce extraneous image information. A common set of terminology is proposed and used. RESULTS: Optical coherence tomography angiography uses motion contrast to image blood flow and thereby images the vasculature without the need for a contrast agent. Artifacts are very common and can arise from the OCT …
Risk Factors Associated With Reticular Pseudodrusen Versus Large Soft Drusen, S. Boddu, M. D. Lee, M. Marsiglia, M. Marmor, K. B. Freund, R. T. Smith
Risk Factors Associated With Reticular Pseudodrusen Versus Large Soft Drusen, S. Boddu, M. D. Lee, M. Marsiglia, M. Marmor, K. B. Freund, R. T. Smith
Journal Articles
PURPOSE: To investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen without reticular pseudodrusen. DESIGN: Prospective case-case comparison. METHODS: In a clinical practice setting, patients with AMD were sequentially screened using clinical examination and scanning laser ophthalmoscopy imaging to prospectively identify subjects (n = 73) with the phenotypes of (1) reticular pseudodrusen without large soft drusen (n = 30) or (2) large soft drusen without reticular pseudodrusen (n = 43). Subjects were genotyped for 2 alleles associated with …
Glycated Hemoglobin Measurement And Prediction Of Cardiovascular Disease, E. Di Angelantonio, P. Gao, H. Khan, N. Wald, S. J. L. Bakker, P. H. Whincup, J. Kauhanen, J. T. Salonen, R. Dankner, J. Danesh, +66 Additional Authors
Glycated Hemoglobin Measurement And Prediction Of Cardiovascular Disease, E. Di Angelantonio, P. Gao, H. Khan, N. Wald, S. J. L. Bakker, P. H. Whincup, J. Kauhanen, J. T. Salonen, R. Dankner, J. Danesh, +66 Additional Authors
Journal Articles
IMPORTANCE The value of measuring levels of glycated hemoglobin (HbA(1c)) for the prediction of first cardiovascular events is uncertain. OBJECTIVE To determine whether adding information on HbA(1c) values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk. DESIGN, SETTING, AND PARTICIPANTS Analysis of individual-participant data available from 73 prospective studies involving 294 998 participants without a known history of diabetes mellitus or CVD at the baseline assessment. MAIN OUTCOMES AND MEASURES Measures of risk discrimination for CVD outcomes (eg, C-index) and reclassification (eg, net reclassification improvement) of participants across predicted 10-year risk categories …
Early Initial Clinical Experience With Intravitreal Aflibercept For Wet Age-Related Macular Degeneration, P. J. Ferrone, F. Anwar, J. Naysan, K. Chaudhary, D. Fastenberg, K. Graham, V. Deramo
Early Initial Clinical Experience With Intravitreal Aflibercept For Wet Age-Related Macular Degeneration, P. J. Ferrone, F. Anwar, J. Naysan, K. Chaudhary, D. Fastenberg, K. Graham, V. Deramo
Journal Articles
Background Age-related macular degeneration (AMD) is a degenerative process that leads to severe vision loss. Wet AMD is defined by choroidal neovascularisation, leading to the accumulation of subretinal fluid (SRF), macular oedema (ME), and pigment epithelium detachments (PED). Purpose To evaluate the initial clinical experience of conversion from bevacizumab or ranibizumab to aflibercept in wet AMD patients. Methods Records of 250 consecutive wet AMD patients were retrospectively reviewed. Of 250 patients, 29 were naive (with no previous treatment), and 221 were previously treated with bevacizumab (1/3) or ranibizumab (2/3). On average, converted patients received 14 injections every 6 weeks on …
Spectral-Domain Optical Coherence Tomography Staging And Autofluorescence Imaging In Achromatopsia, J. P. Greenberg, J. Sherman, S. A. Zweifel, R. W. Chen, T. Duncker, S. Kohl, B. Baumann, B. Wissinger, L. A. Yannuzzi, S. H. Tsang
Spectral-Domain Optical Coherence Tomography Staging And Autofluorescence Imaging In Achromatopsia, J. P. Greenberg, J. Sherman, S. A. Zweifel, R. W. Chen, T. Duncker, S. Kohl, B. Baumann, B. Wissinger, L. A. Yannuzzi, S. H. Tsang
Journal Articles
IMPORTANCE Evidence is mounting that achromatopsia is a progressive retinal degeneration, and treatments for this condition are on the horizon. OBJECTIVES To categorize achromatopsia into clinically identifiable stages using spectral-domain optical coherence tomography and to describe fundus autofluorescence imaging in this condition. DESIGN, SETTING, AND PARTICIPANTS A prospective observational study was performed between 2010 and 2012 at the Edward S. Harkness Eye Institute, New York-Presbyterian Hospital. Participants included 17 patients (aged 10-62 years) with full-field electroretinography-confirmed achromatopsia. MAIN OUTCOMES AND MEASURES Spectral-domain optical coherence tomography features and staging system, fundus autofluorescence and near-infrared reflectance features and their correlation to optical …
Giant Cell Arteritis Presenting With Bilateral Orbital Inflammatory Disease And Enhancing Superficial Temporal Arteries, J. R. Mitchell, I. Krashin-Bichler, M. Rosenblum, E. L. Diamond, M. J. Dinkin
Giant Cell Arteritis Presenting With Bilateral Orbital Inflammatory Disease And Enhancing Superficial Temporal Arteries, J. R. Mitchell, I. Krashin-Bichler, M. Rosenblum, E. L. Diamond, M. J. Dinkin
Journal Articles
No abstract provided.
Gene Therapy In Patient-Specific Stem Cell Lines And A Preclinical Model Of Retinitis Pigmentosa With Membrane Frizzled-Related Protein Defects, Y. Li, W. H. Wu, C. W. Hsu, H. V. Nguyen, Y. T. Tsai, L. Chan, T. Nagasaki, I. H. Maumenee, L. A. Yannuzzi, S. H. Tsang, +3 Additional Authors
Gene Therapy In Patient-Specific Stem Cell Lines And A Preclinical Model Of Retinitis Pigmentosa With Membrane Frizzled-Related Protein Defects, Y. Li, W. H. Wu, C. W. Hsu, H. V. Nguyen, Y. T. Tsai, L. Chan, T. Nagasaki, I. H. Maumenee, L. A. Yannuzzi, S. H. Tsang, +3 Additional Authors
Journal Articles
Defects in Membrane Frizzled-related Protein (MFRP) cause autosomal recessive retinitis pigmentosa (RP). MFRP codes for a retinal pigment epithelium (RPE)-specific membrane receptor of unknown function. In patient-specific induced pluripotent stem (iPS)-derived RPE cells, precise levels of MFRP, and its dicistronic partner CTRP5, are critical to the regulation of actin organization. Overexpression of CTRP5 in naive human RPE cells phenocopied behavior of MFRP-deficient patient RPE (iPS-RPE) cells. AAV8 (Y733F) vector expressing human MFRP rescued the actin disorganization phenotype and restored apical microvilli in patient-specific iPS-RPE cell lines. As a result, AAV-treated MFRP mutant iPS-RPE recovered pigmentation and transepithelial resistance. The efficacy …
Late Recurrence Of Myopic Foveoschisis After Successful Repair With Primary Vitrectomy And Incomplete Membrane Peeling, G. Sepulveda, S. Chang, K. B. Freund, S. Park, Q. V. Hoang
Late Recurrence Of Myopic Foveoschisis After Successful Repair With Primary Vitrectomy And Incomplete Membrane Peeling, G. Sepulveda, S. Chang, K. B. Freund, S. Park, Q. V. Hoang
Journal Articles
PURPOSE: To report three cases of late recurrence of myopic foveoschisis (MF) after initial successful repair with pars plana vitrectomy and membrane peeling to assess the importance of internal limiting membrane peeling. METHODS: A retrospective noncomparative case series was performed of patients who underwent a primary pars plana vitrectomy by a single surgeon with successful resolution of MF, but eventually underwent repeat pars plana vitrectomy for recurrent MF. Best-corrected visual acuity, fundus photography, and optical coherence tomography were obtained at each examination. RESULTS: Three eyes of three patients underwent pars plana vitrectomy for recurrent MF. Myopic foveoschisis recurrence occurred 6, …
Photoreceptor Perturbation Around Subretinal Drusenoid Deposits As Revealed By Adaptive Optics Scanning Laser Ophthalmoscopy, Y. Zhang, X. Wang, E. B. Rivero, M. E. Clark, C. D. Witherspoon, R. F. Spaide, C. A. Girkin, C. Owsley, C. A. Curcio
Photoreceptor Perturbation Around Subretinal Drusenoid Deposits As Revealed By Adaptive Optics Scanning Laser Ophthalmoscopy, Y. Zhang, X. Wang, E. B. Rivero, M. E. Clark, C. D. Witherspoon, R. F. Spaide, C. A. Girkin, C. Owsley, C. A. Curcio
Journal Articles
PURPOSE: To describe the microscopic structure of photoreceptors impacted by subretinal drusenoid deposits, also called pseudodrusen, an extracellular lesion associated with age-related macular degeneration (AMD), using adaptive optics scanning laser ophthalmoscopy (AOSLO). DESIGN: Observational case series. METHODS: We recruited 53 patients with AMD and 10 age-similar subjects who had normal retinal health. All subjects underwent color fundus photography, infrared reflectance, red-free reflectance, autofluorescence, and spectral-domain optical coherence tomography (OCT). Subretinal drusenoid deposits were classified by a 3-stage OCT-based grading system. Lesions and surrounding photoreceptors were examined by AOSLO. RESULTS: Subretinal drusenoid deposits were found in 26 eyes of 13 patients …
Bioactive Lysophospholipids Generated By Hepatic Lipase Degradation Of Lipoproteins Lead To Complement Activation Via The Classical Pathway, W. Ma, D. C. Paik, G. R. Barile
Bioactive Lysophospholipids Generated By Hepatic Lipase Degradation Of Lipoproteins Lead To Complement Activation Via The Classical Pathway, W. Ma, D. C. Paik, G. R. Barile
Journal Articles
PURPOSE: We determined bioactivity of lysophospholipids generated by degradation of the low-density (LDL), very low-density (VLDL), and high-density (HDL) lipoproteins with hepatic lipase (HL), cholesterol esterase (CE), and lipoprotein-associated phospholipase A2 (Lp-PLA2). METHODS: The LDL, VLDL, and HDL were treated with HL, CE, and Lp-PLA2 after immobilization on plates, and complement activation studies were performed with diluted human serum. Complement component 3 (C3) fixation, a marker for complement activation, was determined with a monoclonal anti-human C3d antibody. Enzymatic properties of HL and CE were assayed with triglyceride and phosphatidylcholine substrates for triglyceride hydrolase and phospholipase A activities. The ARPE-19 cells …
Complete Binasal Hemianopia, B. T. Bryan, H. D. Pomeranz, K. H. Smith
Complete Binasal Hemianopia, B. T. Bryan, H. D. Pomeranz, K. H. Smith
Journal Articles
Binasal hemianopia is a rarely encountered visual field defect. We examined two asymptomatic female patients, aged 17 and 83, with complete binasal hemianopia. Both patients had unremarkable eye exams except for the visual field deficits and minimally reduced visual acuity and color vision. Both patients had normal neuroimaging. These are the first reported cases of complete binasal visual field defects without an identifiable ocular or neurologic cause.
Assessing The Cone Photoreceptor Mosaic In Eyes With Pseudodrusen And Soft Drusen In Vivo Using Adaptive Optics Imaging, S. Mrejen, T. Sato, C. A. Curcio, R. F. Spaide
Assessing The Cone Photoreceptor Mosaic In Eyes With Pseudodrusen And Soft Drusen In Vivo Using Adaptive Optics Imaging, S. Mrejen, T. Sato, C. A. Curcio, R. F. Spaide
Journal Articles
PURPOSE: To investigate the cone photoreceptor mosaic in eyes with pseudodrusen as evidenced by the presence of subretinal drusenoid deposits (SDD) and conventional drusen using adaptive optics (AO) imaging integrated into a multimodal imaging approach. DESIGN: Observational case series. PARTICIPANTS: Eleven patients (11 eyes) with pseudodrusen and 6 patients (11 eyes) with conventional drusen. METHODS: Consecutive patients were examined using near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO) and eye-tracked spectral-domain optical coherence tomography (SD-OCT) and flood-illuminated retinal AO camera of nonconfluent pseudodrusen or conventional drusen. Correlations were made between the IR-SLO, SD-OCT, and AO images. Cone density analysis was …
Sequential Bilateral Central Retinal Vein Occlusions In A Cystic Fibrosis Patient With Hyperhomocysteinemia And Hypergamma-Globulinemia, R. Gelman, E. A. Dimango, W. M. Schiff
Sequential Bilateral Central Retinal Vein Occlusions In A Cystic Fibrosis Patient With Hyperhomocysteinemia And Hypergamma-Globulinemia, R. Gelman, E. A. Dimango, W. M. Schiff
Journal Articles
PURPOSE: To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up. METHODS: Observational case report of one patient. RESULTS: A 31 year-old male with a history of cystic fibrosis presented with a central retinal vein occlusion (CRVO) in his left eye, followed by a CRVO in his right eye 4 years later. His medical workup was significant for elevated levels of homocysteine and gamma-globulins, which coincided with initiation of intravenous immunoglobulin (IVIG) proceeding his second CRVO. CONCLUSIONS: We describe a case of sequential bilateral …