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Full-Text Articles in Medicine and Health Sciences
Oxidative Stress And Cell Death In Osmotically Swollen Glial Cells, Crystal Elaine Stuckey
Oxidative Stress And Cell Death In Osmotically Swollen Glial Cells, Crystal Elaine Stuckey
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Regulation of normal volume is an important aspect of cell homeostasis. Possible mechanisms which signal volume regulation are increasing the rate of reactive oxygen species (ROS) production and release of ATP for interaction with purinergic receptors. We examined whether an increase in ROS production during cell swelling also led to cell injury of C6 glioma cells. Cells were loaded with 5,6-carboxy-2,7-dihydrofluorscein diacetate (DCFDA) to fluoroscopically measure the rate of cellular ROS production and were perfused with phosphate-buffered saline solutions (PBS) containing 100 μM carbenoxolone to inhibit dye efflux. Cell death was determined cytometrically and by measuring the release of lactate …
Effects Of Sepsis On Nerve Evoked Responses, Kevin Richard Novak
Effects Of Sepsis On Nerve Evoked Responses, Kevin Richard Novak
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Sepsis and SIRS (systemic inflammatory response syndrome) have become two expensive and complicated problems seen in the intensive care unit (ICU). These two illnesses have been known to cause dysfunction with excitable tissues in the body. Encephalopathy, neuropathy, and myopathy are the three biggest. In this paper we discuss the development of an animal model of sepsis and the neurological complications sepsis brought about. Nerve conduction studies showed increased durations on compound muscle action potential, and decreased amplitude as well as increased duration and latency on sensory nerve action potentials. These results were not consistent with the two most common …
Effects Of Subcutaneous Postnatal Choline Supplementation On Hippocampus-Mediated Learning And Memory In Rat Pups, Jeremy Alan Moore
Effects Of Subcutaneous Postnatal Choline Supplementation On Hippocampus-Mediated Learning And Memory In Rat Pups, Jeremy Alan Moore
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The effects of postnatal injections of choline on the acquisition of two variants of eyeblink conditioning were examined in developing Long-Evans rat pups. Choline administration on postnatal days (PND) 15-27 was followed by evaluation of trace eyeblink conditioning (Experiment 1) and delay eyeblink conditioning (Experiment 2) on PND 28-29. The results of these experiments show that choline produced greater improvements in learning and memory during the trace condition than in the delay condition, presumably due to its effect on the hippocampus. Trace eyeblink conditioning relies heavily on an intact hippocampus but delay eyeblink conditioning does not, and it is understood …
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
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This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10μg/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10μg/.2ml and 20μg/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose …