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Full-Text Articles in Medicine and Health Sciences
Improved De Novo Alignment Of A Girardia Dorotocephala Ma-C2 (2n = 24) Transcriptome, Labib Rouhana, J F. Ryan, Eugene M. P. Almazan
Improved De Novo Alignment Of A Girardia Dorotocephala Ma-C2 (2n = 24) Transcriptome, Labib Rouhana, J F. Ryan, Eugene M. P. Almazan
Biological Sciences Faculty Publications
Improved De novo alignment of a Girardia dorotocephala MA-C2 (2n = 24) transcriptome.
Wright State University Boonshoft School Of Medicine, Brenda Roman, Colleen Hayden, Irina Overman
Wright State University Boonshoft School Of Medicine, Brenda Roman, Colleen Hayden, Irina Overman
Medical Education Faculty Publications
No abstract provided.
18F-Fallypride Binding Potential In Patients With Schizophrenia Compared To Healthy Controls, Douglas S. Lehrer, Bradley T. Christian, Cemil Kirbas, Meicheng Chiang, Shawn Sidhu, Holly Short, Binquan Wang, Bingzhi Shi, King Wai Chu, Brian Merrill, Monte S. Buchsbaum
18F-Fallypride Binding Potential In Patients With Schizophrenia Compared To Healthy Controls, Douglas S. Lehrer, Bradley T. Christian, Cemil Kirbas, Meicheng Chiang, Shawn Sidhu, Holly Short, Binquan Wang, Bingzhi Shi, King Wai Chu, Brian Merrill, Monte S. Buchsbaum
Psychiatry Faculty Publications
Background: Molecular imaging of dopaminergic parameters has contributed to the dopamine hypothesis of schizophrenia, expanding our understanding of pathophysiology, clinical phenomenology and treatment. Our aim in this study was to compare 18F-fallypride binding potential BPND in a group of patients with schizophrenia-spectrum illness vs. controls, with a particular focus on the cortex and thalamus. Methods: We acquired 18F-fallypride positron emission tomography images on 33 patients with schizophrenia spectrum disorder (28 with schizophrenia; 5 with schizoaffective disorder) and 18 normal controls. Twenty-four patients were absolutely neuroleptic naïve and nine were previously medicated, although only four had a lifetime neuroleptic exposure of …
Atrioventricular Nodal Function In The Immature Canine Heart, Jorge Mccormack, Henry Gelband, Hui Xu, Juan Villafane, Adrienne Stolfi, Arthur S. Pickoff
Atrioventricular Nodal Function In The Immature Canine Heart, Jorge Mccormack, Henry Gelband, Hui Xu, Juan Villafane, Adrienne Stolfi, Arthur S. Pickoff
Medical Education Faculty Publications
Previous studies have suggested that the atrioventricular nodal functional refractory period in the neonate is equal to or shorter than that of the ventricle, providing little or no protection to the ventricle against rapid atrial rates and allowing closely coupled atrial beats to fall within the ventricular vulnerable period. We evaluated atrioventricular node function in 21 mongrel neonatal puppies, 3-15 days old, and 15 adult dogs utilizing intracardiac His bundle recording and stimulation techniques. The mean atrioventricular nodal functional refractory period (173.1 ± 20.0 ms) exceeded both the ventricular effective refractory period (139.5 ± 14.3) and ventricular functional refractory period …
In Vivo Demonstration Of Maturational Changes Of The Chronotropic Response To Α-Adrenergic Stimulation, Jorge Mccormack, Henry Gelband, Juan Villafañe, Hui Xu, Adrienne Stolfi, Arthur S. Pickoff
In Vivo Demonstration Of Maturational Changes Of The Chronotropic Response To Α-Adrenergic Stimulation, Jorge Mccormack, Henry Gelband, Juan Villafañe, Hui Xu, Adrienne Stolfi, Arthur S. Pickoff
Medical Education Faculty Publications
In vitro studies suggest that neonates and adults may have different cardiac chronotropic responses to a-adrenergic stimulation. To investigate these differences in vivo, three groups of dogs were studied. Group I = 12 puppies, ages 3-7 days; group II = 12 puppies ages 8-15 days, and group III = seven adult dogs. Heart rate and blood pressure determinations were made in the control setting and then after combined β-adrenergic and parasympathetic blockade (propranolol 0.6 mg/kg and bilateral vagotomies). Alpha-stimulation was then achieved with phenylephrine given in doses of 0.5, 1.0, and 10.0 μg/kg/ min. A second, high dose of propranolol …
Digoxin-Quinidine Interaction In The Neonatal Dog, Arthur S. Pickoff, Adrienne Stolfi, Henry Gelband
Digoxin-Quinidine Interaction In The Neonatal Dog, Arthur S. Pickoff, Adrienne Stolfi, Henry Gelband
Medical Education Faculty Publications
The effects of quinidine on steady state serum and tissue digoxin concentrations in the neonatal dog were studied. To determine the effects of quinidine on serum digoxin concentrations, two groups of neonates were evaluated: Group I (n = 11) was digitalized with 40 μg/kg body weight, intramuscularly, and placed on a 10 μg/kg per day maintenance dose; Group II (n = 7) was digitalized with 50 μg/kg per day, intraperitoneally, and placed on a 20 μg/kg per day maintenance dose. After 10 days of digoxin alone, quinidine was coadministered (30 mg/kg per day, intraperitoneally) for 7 days. Serum digoxin concentrations …