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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
The Role Of Menin-Mll Interaction In The Dissociation Between Cholestatic Liver Diseases And Cholangiocarcinoma, Laurent Ehrlich 2085637, Chad Hall Dr., Tori Sheppard, Julie Venter, April O'Brien, Terry C. Lairmore Dr., Gianfranco Alpini Dr., Shannon Glaser Dr.
The Role Of Menin-Mll Interaction In The Dissociation Between Cholestatic Liver Diseases And Cholangiocarcinoma, Laurent Ehrlich 2085637, Chad Hall Dr., Tori Sheppard, Julie Venter, April O'Brien, Terry C. Lairmore Dr., Gianfranco Alpini Dr., Shannon Glaser Dr.
Hepatobiliary Cancers: Pathobiology and Translational Advances
No abstract provided.
Correction: The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
Correction: The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
Human and Molecular Genetics Publications
This is a correction to a previously published article.
The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
The Role Of Tumor-Associated Macrophages In Tumor Vascularization, Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B. Fisher, Xiang-Yang Wang
Human and Molecular Genetics Publications
Tumor vascularization is a highly complex process that involves the interaction between tumors and their surrounding stroma, as well as many distinct angiogenesis-regulating factors. Tumor associated macrophages (TAMs) represent one of the most abundant cell components in the tumor environment and key contributors to cancer-related inflammation. A large body of evidence supports the notion that TAMs play a critical role in promoting the formation of an abnormal tumor vascular network and subsequent tumor progression and invasion. Clinical and experimental evidence has shown that high levels of infiltrating TAMs are associated with poor patient prognosis and tumor resistance to therapies. In …
Angiogenesis In Response To Varying Fiber Size In An Electrospun Scaffold In Vivo., Damien Brown
Angiogenesis In Response To Varying Fiber Size In An Electrospun Scaffold In Vivo., Damien Brown
Theses and Dissertations
Injury to the spinal cord results in partial or complete loss of sensory perception and motor function. After spinal cord injury (SCI), damaged tissue dies and a cavity will form. This cavity prevents the regeneration of tissue and any functional recovery. One way to address the cavity is the insertion of an electrospun scaffold that our lab has created. This provides a substrate for regenerating tissue to grow on, and it is thought that reestablishing the blood supply within the scaffold will allow cells necessary for regeneration to thrive. This could ultimately lead to meaningful recovery for patients who have …
Identification Of Clinical, Laboratory And Genetic Covariates For Pharmacokinetics, Efficacy And Toxicity Of Sorafenib In Patients With Solid Tumors, Lokesh Jain
Theses and Dissertations
The goal of this research work was to understand the clinical-pharmacology based treatment approaches for sorafenib. Treatment with sorafenib is associated with high inter-patient variability in pharmacokinetic exposures, efficacy and toxicity. We explored the demographic, laboratory, clinical and pharmacogenetic factors to elucidate the sources of variability. In addition, we examined the impact of pharmacogenetic variation in VEGFR2, an important mediator of the VEGF pathway, on risk of prostate cancer. To support these investigations, (mainly single-dose) pharmacokinetic, pharmacogenetic, efficacy and toxicity information were collected from patients with solid tumors, enrolled in five phase I / II clinical trials at National Cancer …