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Full-Text Articles in Medicine and Health Sciences

Chronotropic Intolerance: An Overlooked Determinant Of Symptoms And Activity Limitation In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?, Todd E. Davenport, Mary Lehnen, Staci R. Stevens, J. Mark Vanness, Jared Stevens, Christopher R. Snell Jan 2019

Chronotropic Intolerance: An Overlooked Determinant Of Symptoms And Activity Limitation In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?, Todd E. Davenport, Mary Lehnen, Staci R. Stevens, J. Mark Vanness, Jared Stevens, Christopher R. Snell

All Faculty Scholarship

Post-exertional malaise (PEM) is the hallmark clinical feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). PEM involves a constellation of substantially disabling signs and symptoms that occur in response to physical, mental, emotional, and spiritual over-exertion. Because PEM occurs in response to over-exertion, physiological measurements obtained during standardized exertional paradigms hold promise to contribute greatly to our understanding of the cardiovascular, pulmonary, and metabolic states underlying PEM. In turn, information from standardized exertional paradigms can inform patho-etiologic studies and analeptic management strategies in people with ME/CFS. Several studies have been published that describe physiologic responses to exercise in people with ME/CFS, …


Exercise And Patient Populations: A Community-Based Exercise Intervention On Cancer And Type 2 Diabetes, Cynthia Villalobos Jan 2019

Exercise And Patient Populations: A Community-Based Exercise Intervention On Cancer And Type 2 Diabetes, Cynthia Villalobos

University of the Pacific Theses and Dissertations

Cancer and diabetes are the second and seventh leading causes of death in the United States, respectively (Kochanek et al., 2017). When including prediabetes and the entire cancer continuum, both diseases affect over 150 million individuals in the United States each year (Bullard et al., 2018; Siegel et al., 2019). Furthermore, there exists an alarming rise in patients presenting with both type 2 diabetes and obesity-related cancers concurrently, as both diseases share similar risk factors (Vigneri et al., 2009). An aging adult population, physical inactivity and unhealthy eating habits are continuing to rise, and the prevalence of individuals with obesity-related …