Medicine and Health Sciences Commons^™

Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han

Faculty of Health and Behavioural Sciences - Papers (Archive)

Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …

Facts On Fats: What Are The Implications?, Jie J. Wang, Victoria M. Flood, Paul Mitchell

Faculty of Health and Behavioural Sciences - Papers (Archive)

We are delighted to see a cross-discipline review article by Chong, Sinclair and Guymer appearing in this issue of CEO (‘Facts on fat’, pp. 464–471). As the authors anticipate, this review provides valuable information to readers of the Journal, who are mostly ophthalmologists. We also believe that this cross-discipline review article will enable readers to better understand the roles of dietary fats, and be in a position to convey better quality information to their patients. Given that a possible association between dietary fatty acid intake and age-related macular degeneration is a current hot topic in the ophthalmic literature, this review …

Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else

Faculty of Health and Behavioural Sciences - Papers (Archive)

Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …

Western Australians' Perceptions Of The Survivability Of Different Cancers: Implications For Public Education Campaigns, Robert J Donovan, Owen Bj Carter, Geoffrey Jalleh, Sandra C. Jones

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.

Fgf-2 Counteracts Loss Of Tgfβ Affected Cells From Rat Lens Explants: Implications For Pco (After Cataract), Kylie Mansfield, Anna Cerra, Coral Chamberlain

Faculty of Science, Medicine and Health - Papers: part A

Purpose: While cataract surgery initially benefits most patients, many suffer secondary loss of vision because of posterior capsule opacification (PCO). Lens epithelial cells left behind at surgery become aberrant and migrate into the light path. TGF-beta (TGFβ) appears to play a key role in this process by inducing the cells to undergo an epithelial-mesenchymal transition. Paradoxically, it also typically induces them to undergo apoptotic death. The present study was undertaken to investigate the hypothesis that FGF plays a role in PCO formation by promoting the survival of abnormal cells with PCO-like characteristics.

Methods: Rat lens epithelial explants were cultured for …