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Full-Text Articles in Medicine and Health Sciences
Perinatal Administration Of Phencyclidine Alters Expression Of Lingo-1 Signaling Pathway Proteins In The Prefrontal Cortex Of Juvenile And Adult Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright
Perinatal Administration Of Phencyclidine Alters Expression Of Lingo-1 Signaling Pathway Proteins In The Prefrontal Cortex Of Juvenile And Adult Rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, Francesca Fernandez-Enright
Illawarra Health and Medical Research Institute
Postnatal administration of phencyclidine (PCP) in rodents causes major brain dysfunction leading to severe disturbances in behavior lasting into adulthood. This model is routinely employed to model psychiatric disorders such as schizophrenia, as it reflects schizophrenia related brain disturbances in cluding increased apoptosis, a nd disruptions to myelin and plasticity processes. Leucine -rich repeat and immunoglobulin domain-containing protein, Lingo-1, is a potent negative regulator of both axonal myelination and neurite extension. The Nogo receptor (NgR)/TNF receptor orphan Y (T ROY) and/or p75 complex, With No Lysine (K) (WNK1) and Myelin transcription factor-1 (Myt1) are co-receptors or co-factors in Lingo- 1 …
Medication Administration And Final Year Nursing Students, Kerry Reid-Searl, Lorna Moxham, Sandra Walker
Medication Administration And Final Year Nursing Students, Kerry Reid-Searl, Lorna Moxham, Sandra Walker
Faculty of Science, Medicine and Health - Papers: part A
The literature continues to report on medication errors occurring within Australian health care facilities every year. For this reason anyone who is admitted into a health care facility and is required to have medications is at risk of being the recipient of an unintentional medication error. Because nurses are primarily the health care professionals who administer medications to patients, students in undergraduate nursing programs are taught that this skill demands absolute vigilance in safety. This paper reports on a PhD study aimed at identifying the experiences of final year undergraduate nursing students when administering medications to patients in the clinical …
Intranasal Administration Of A Parg Inhibitor Profoundly Decreases Ischemic Brain Injury, Guangwei Wei, Dongmin Wang, Huafei Lu, Sophie Parmentier, Qing Wang, S. Scott Panter, William H. Frey Ii, Weihai Ying
Intranasal Administration Of A Parg Inhibitor Profoundly Decreases Ischemic Brain Injury, Guangwei Wei, Dongmin Wang, Huafei Lu, Sophie Parmentier, Qing Wang, S. Scott Panter, William H. Frey Ii, Weihai Ying
Faculty of Health and Behavioural Sciences - Papers (Archive)
Cumulative evidence has indicated a critical role of poly(ADP-ribose) polymerase-1 activation in ischemic brain damage. Poly(ADP-ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP-ribose) catabolism. Our previous studies showed that PARG inhibitors, gallotannin (GT) and nobotanin B, can profoundly decrease oxidative cell death in vitro. Here, we tested the hypothesis that intranasal delivery of GT can decrease ischemic brain damage by inhibiting PARG. Intranasal delivery of GT within 5 hours after the onset of focal brain ischemia markedly decreased the infarct formation and neurological deficits of rats. The GT administration also increased poly(ADP-ribose) in the ischemic brains, suggesting that …
Depletion Of Glutathione And Enhanced Lipid Peroxidation In The Csf Of Acute Psychotics Following Haloperidol Administration., B. Nagesh Pai, N. Janakiramaih, B. N. Gangadhar, Vijayalakshmi Ravindranath
Depletion Of Glutathione And Enhanced Lipid Peroxidation In The Csf Of Acute Psychotics Following Haloperidol Administration., B. Nagesh Pai, N. Janakiramaih, B. N. Gangadhar, Vijayalakshmi Ravindranath
Graduate School of Medicine - Papers (Archive)
Haloperidol administration for 2 weeks results in significant reduction in the concentration of GSH in the CSF. Concomitantly, the levels of lipid peroxidation products increased as evidenced by increased malondialdehyde levels. The malondialdehyde levels in the CSF prior to haloparidol administration were not significantly higher than that seen in CSF from normal controls (data not shown) suggesting that increased oxidative stress did not exist in these patients prior to haloperidol administration. All the patients included in the present study were drug naive and hence the changes observed in the glutathione and malon6ialdehyde levels in the CSF were indeed mediated by …