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Antidepressants And Inflammatory Bowel Disease: A Systematic Review, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann

Graduate School of Medicine - Papers (Archive)

Background: A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological comorbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. Methods: We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. Results: 12 relevant publications were identified. All of them referred …