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Full-Text Articles in Medicine and Health Sciences
Expression Of Lpp3 In Bergmann Glia Is Required For Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling And Development, Alejandro Lopez-Juarez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J. Morris, Diana Escalante-Alcalde
Expression Of Lpp3 In Bergmann Glia Is Required For Proper Cerebellar Sphingosine-1-Phosphate Metabolism/Signaling And Development, Alejandro Lopez-Juarez, Sara Morales-Lázaro, Roberto Sánchez-Sánchez, Manjula Sunkara, Hilda Lomelí, Iván Velasco, Andrew J. Morris, Diana Escalante-Alcalde
Health & Biomedical Sciences Faculty Publications and Presentations
Bioactive lipids serve as intracellular and extracellular mediators in cell signaling in normal and pathological conditions. Here we describe that an important regulator of some of these lipids, the lipid phosphate phosphatase-3 (LPP3), is abundantly expressed in specific plasma membrane domains of Bergmann glia (BG), a specialized type of astrocyte with key roles in cerebellum development and physiology. Mice selectively lacking expression of LPP3/Ppap2b in the nervous system are viable and fertile but exhibit defects in postnatal cerebellum development and modifications in the cytoarchitecture and arrangement of BG with a mild non-progressive motor coordination defect. Lipid and gene profiling studies …