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Pten Function In Postnatal Brain Development And Tumorigenesis, Guo Zhu
Pten Function In Postnatal Brain Development And Tumorigenesis, Guo Zhu
Theses and Dissertations (ETD)
PTEN (Phosphatase and Tensin homolog deleted on chromosome 10) is a tumor suppressor gene that is commonly mutated in multiple types of human cancers including endometrial, prostate, breast cancers and glioblastoma multiforme (GBM). PTEN functions as a phospholipid phosphatase antagonizing phosphorylation by phosphatidylinositol‑3‑OH kinases (PI3Ks) and thus serves as a major negative regulator of the PI3K pathway. Homozygous Pten knock-out mice die during embryogenesis. Conditional Pten knock-out in the nervous system showed that Pten negatively regulates self-renewal and proliferation of neural stem cells, negatively controls neuronal size, is required for proper neuronal positioning and is involved in the development and …