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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Alternative Targets For The Treatment Of Stroke, Craig T. Ajmo Jr.
Alternative Targets For The Treatment Of Stroke, Craig T. Ajmo Jr.
USF Tampa Graduate Theses and Dissertations
Stroke is cerebrovascular injury that has been reported to be the third leading cause of death and the first leading cause of disability in the world (W. H.O. 2007). Currently, there is only one FDA approved treatment for stroke which is recombinant tissue plasminogen activator. This treatment has a narrow therapeutic window of three hours after ischemic stroke and can adversely cause the production of oxygen free radicals and intracranial hemorrhage. These limitations result in only 2-3% of all stroke victims as being candidates for this therapy as many patients do not arrive at the hospital in time to receive …
Composition Profiler: A Tool For Discovery And Visualization Of Amino Acid Composition Differences, Vladimir Vacic, Vladimir N. Uversky, A. Keith Dunker, Stefano Lonardi
Composition Profiler: A Tool For Discovery And Visualization Of Amino Acid Composition Differences, Vladimir Vacic, Vladimir N. Uversky, A. Keith Dunker, Stefano Lonardi
Molecular Medicine Faculty Publications
Background: Composition Profiler is a web-based tool for semi-automatic discovery of enrichment or depletion of amino acids, either individually or grouped by their physico-chemical or structural properties.
Results: The program takes two samples of amino acids as input: a query sample and a reference sample. The latter provides a suitable background amino acid distribution, and should be chosen according to the nature of the query sample, for example, a standard protein database (e.g. SwissProt, PDB), a representative sample of proteins from the organism under study, or a group of proteins with a contrasting functional annotation. The results of the analysis …
Disprot: The Database Of Disordered Proteins, Megan D. Sickmeier, Justin A. Hamilton, Tanguy Legall, Vladimir Vacic, Marc S. Cortese, Agnes Tantos, Beata Szabo, Peter Tompa, Jake Chen, Vladimir N. Uversky, Zoran Obradovic, A. Keith Dunker
Disprot: The Database Of Disordered Proteins, Megan D. Sickmeier, Justin A. Hamilton, Tanguy Legall, Vladimir Vacic, Marc S. Cortese, Agnes Tantos, Beata Szabo, Peter Tompa, Jake Chen, Vladimir N. Uversky, Zoran Obradovic, A. Keith Dunker
Molecular Medicine Faculty Publications
The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed three-dimensional structure under physiological conditions, either in their entireties or in segments or regions. We define IDP as a protein that contains at least one experimentally determined disordered region. Although lacking fixed structure, IDPs and regions carry out important biological functions, being typically involved in regulation, signaling and control. Such functions can involve high-specificity low-affinity interactions, the multiple binding of one protein to many partners and the multiple binding of many proteins to one partner. These …
Ketamine-Enhanced Psychotherapy: Preliminary Clinical Observations On Its Effects In Treating Death Anxiety, Eli Kolp, M. Scott Young, Harris L. Friedman, Evgeny Krupitsky, Karl Jansen, Laurie-Ann O'Connor
Ketamine-Enhanced Psychotherapy: Preliminary Clinical Observations On Its Effects In Treating Death Anxiety, Eli Kolp, M. Scott Young, Harris L. Friedman, Evgeny Krupitsky, Karl Jansen, Laurie-Ann O'Connor
Mental Health Law & Policy Faculty Publications
Ketamine, a dissociative anesthetic commonly used by US physicians, has recently been shown to be a powerful anti-depressant and is also capable of eliciting transpersonal experiences that can be transformative. Although currently approved in the US only for use as an anesthetic, physicians there can legally prescribe it off-label to treat various psychological/ psychiatric problems and it has been used for these non-anesthetic purposes in Argentina, Iran, Mexico, Russia, and the UK, as well as in the US. The literature on using ketamine psychotherapeutically is reviewed and two case studies using ketamine-enhanced psychotherapy (KEP) for treating death anxiety in terminally-ill …