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Full-Text Articles in Medicine and Health Sciences
Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva
Intrinsic Disorder Is A Common Feature Of Hub Proteins From Four Eukaryotic Interactomes, Chad Haynes, Christopher J. Oldfield, Fei Ji, Niels Klitgord, Michael E. Cusick, Predrag Radivojac, Vladimir N. Uversky, Mark Vidal, Lilia M. Iakoucheva
Molecular Medicine Faculty Publications
Recent proteome-wide screening approaches have provided a wealth of information about interacting proteins in various organisms. To test for a potential association between protein connectivity and the amount of predicted structural disorder, the disorder propensities of proteins with various numbers of interacting partners from four eukaryotic organisms (Caenorhabditis elegans, Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens) were investigated. The results of PONDR VL-XT disorder analysis show that for all four studied organisms, hub proteins, defined here as those that interact with ≥10 partners, are significantly more disordered than end proteins, defined here as those that interact with just one partner. …
Local Flexibility In Molecular Function Paradigm, Jag Bhalla, Geoffrey B. Storchan, Caitlin M. Maccarthy, Vladimir N. Uversky, Olga Tcherkasskaya
Local Flexibility In Molecular Function Paradigm, Jag Bhalla, Geoffrey B. Storchan, Caitlin M. Maccarthy, Vladimir N. Uversky, Olga Tcherkasskaya
Molecular Medicine Faculty Publications
It is generally accepted that the functional activity of biological macromolecules requires tightly packed three-dimensional structures. Recent theoretical and experimental evidence indicates, however, the importance of molecular flexibility for the proper functioning of some proteins. We examined high resolution structures of proteins in various functional categories with respect to the secondary structure assessment. The latter was considered as a characteristic of the inherent flexibility of a polypeptide chain. We found that the proteins in functionally competent conformational states might be comprised of 20–70% flexible residues. For instance, proteins involved in gene regulation, e.g. transcription factors, are on average largely disordered …
Quality Of Life Measurement In Persons With Schizophrenia: Are We Measuring What’S Important?, Marion Becker, Ronald J. Diamond
Quality Of Life Measurement In Persons With Schizophrenia: Are We Measuring What’S Important?, Marion Becker, Ronald J. Diamond
Mental Health Law & Policy Faculty Publications
No abstract provided.