Medicine and Health Sciences Commons^™

Mechanisms Of Arsenic-Induced Suppression Of Early Red Blood Cell Development, Sebastian Medina

Biomedical Sciences ETDs

Anemia adversely impacts the health of more than a billion people worldwide. A strong association between anemia and arsenic exposure has been reported in epidemiological studies from multiple countries. However, the mechanistic bases for the association between arsenic exposure and anemia is not fully understood. In this study, we found an inverse association between drinking water arsenic exposures and clinical indicators of anemia (i.e., red blood cell counts and hematocrit/packet cell volumes) in a cohort of men from rural Bangladesh enrolled in the Health Effects of Arsenic Longitudinal Study.

Follow-up studies in mice, revealed that 60-day exposure to trivalent inorganic …

'Nephrogenic' Systemic Fibrosis Is Mediated By Myeloid C-C Chemokine Receptor 2 Dataset, Catherine Do, Viktor Drel, Chunyan Tan, Duck-Yoon Lee, Brent Wagner

The Kidney Institute of New Mexico

This dataset presents results of an in vivo model of gadolinium-based contrast agent-induced systemic fibrosis. Figure 1 demonstrates that gadolinium-based contrast agent treatment induces dermal fibrosis and hypercellularity of the same magnitude in patients afflicted with ‘nephrogenic’ systemic fibrosis. Electron microscopy demonstrated that systemic gadolinium treatment induced the formation of multinucleated giant cells in the dermis laden with electron-dense, mesh-like nanostructures. Scanning transmission electron microscopy with energy-dispersive spectroscopy revealed that the electron-dense nanoparticles were gadolinium rich. Figure 2 represents the first chimeric model of mice and gadolinium-induced systemic fibrosis (to our knowledge). Lethally-irradiated mice with 5/6 nephrectomy (to model renal …