Medicine and Health Sciences Commons^™

Functional Properties Of The Hiv-1 Subtype C Envelope Glycoprotein Associated With Mother-To-Child Transmission, Hong Zhang, Marzena Rola, John T. West, Damien C. Tully, Piotr Kubis, Jun He, Chipepo Kankasa, Charles Wood

Nebraska Center for Virology: Faculty Publications

Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterized the viral envelope glycoproteins from six mother-infant transmission pairs and determined whether any specific envelope functions correlate with HIV-1 subtype C perinatal transmission. We found that most newly transmitted viruses were less susceptible to neutralization by their maternal plasma compared to contemporaneous maternal viruses. However, the …

Chronology And Evolution Of The Hiv-1 Subtype C Epidemic In Ethiopia, Damien C. Tully, Charles Wood

Nebraska Center for Virology: Faculty Publications

Objective—To reconstruct the onset date and evolutionary history of the HIV-1 subtype C epidemic in Ethiopia - one of the earliest recorded subtype C epidemics in the world.

Design—HIV-1 C env sequences with a known sampling year isolated from HIV-1 positive patients from Ethiopia between 1984 and 2003.

Methods—Evolutionary parameters including origin and demographic growth patterns were estimated using a Bayesian coalescent-based approach under either strict or relaxed molecular clock models.

Results—Bayesian evolutionary analysis indicated a most recent common ancestor date of 1965 with three distinct epidemic growth phases. Regression analysis of root-to-tip distances revealed a highly similar estimate for …

Enhancement Of Autophagy During Lytic Replication By The Kaposi’S Sarcoma-Associated Herpesvirus Replication And Transcription Activator, Hui-Ju Wen, Zhilong Yang, You Zhou, Charles Wood

Nebraska Center for Virology: Faculty Publications

Autophagy is one of two major degradation systems in eukaryotic cells. The degradation mechanism of autophagy is required to maintain the balance between the biosynthetic and catabolic processes and also contributes to defense against invading pathogens. Recent studies suggest that a number of viruses can evade or subvert the host cell autophagic pathway to enhance their own replication. Here, we investigated the effect of autophagy on the KSHV (Kaposi’s sarcoma-associated herpesvirus) life cycle. We found that the inhibition of autophagy reduces KSHV lytic reactivation from latency, and an enhancement of autophagy can be detected during KSHV lytic replication. In addition, …

Chlorella Viruses Encode Most, If Not All, Of The Machinery To Glycosylate Their Glycoproteins Independent Of The Endoplasmic Reticulum And Golgi, James L. Van Etten, James Gurnon, Giane M. Yanai-Balser, David Dunigan, Michael V. Graves

Nebraska Center for Virology: Faculty Publications

In contrast to all other viruses that use the host machinery located in the endoplasmic reticulum and Golgi to glycosylate their glycoproteins, the large dsDNA-containing chlorella viruses encode most, if not all, of the components to glycosylate their major capsid proteins. Furthermore, all experimental results indicate that glycosylation occurs independent of the endoplasmic reticulum and Golgi. (Review article)

Towards An Understanding Of The Herpes Simplex Virus Type 1 Latency-Reactivation Cycle, Guey-Chuen Perng, Clinton Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Infection by herpes simplex virus type 1 (HSV-1) can cause clinical symptoms in the peripheral and central nervous system. Recurrent ocular shedding can lead to corneal scarring and vision loss making HSV-1 a leading cause of corneal blindness due to an infectious agent. The primary site of HSV-1 latency is sensory neurons within trigeminal ganglia. Periodically, reactivation from latency occurs resulting in virus transmission and recurrent disease. During latency, the latency-associated transcript (LAT) is abundantly expressed. LAT expression is important for the latency-reactivation cycle in animal models, in part, because it inhibits apoptosis, viral gene expression, and productive infection. A …

A Preliminary Study: Body Dysmorphic Disorder In Division I Women’S Collegiate Soccer Players, Tammy D. Jones

Department of Educational Administration: Dissertations, Theses, and Student Research

The prevalence of Body Dysmorphic Disorder (BDD) among collegiate athletes has not been clearly determined. The purpose of this study was to determine if there are symptoms of body dysmorphic disorder found in Division I women’s soccer players. The researcher hypothesized that there would be some symptoms found within the participants of sport and that there was a need to research this area further.

The study consisted of four participants who participated in semi-structured interviews. The subjects were asked a series of questions from the Yale-Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder (BDD-YBOCS) to determine if they indicated …

Cardiovascular Disease Risk Factors And Associations With Indicators Of Body Fat, Diet, And Physical Activity In U.S. Children Ages 6-11, Melissa A. Masters

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Research was conducted to determine the prevalence of cardiovascular disease risk factors in U.S. children ages 6-11 and associations with body fat, diet, and physical activity. Data for 685 children ages 6-11 was obtained from the National Health and Nutrition Examination Survey (NHANES). NHANES data was examined to determine the prevalence of cardiovascular disease risk factors in these children, the impact of indicators of body fat on cardiovascular disease risk factors, the association between cardiovascular disease risk factors and dietary components, and the relationship between physical activity and cardiovascular disease risk factors among U.S. children. Children were also evaluated for …

Research Methodology For Validation Of Nutrition Diagnostic Standardized Language Using Fehring Models, Paula K. Ritter-Gooder, Nancy M. Lewis

Department of Nutrition and Health Sciences: Faculty Publications

Validation of the nutrition standardized language (SL) confirms the language is accurate for use in practice, research, and policy. Nutrition diagnostic terms are identified by concept analysis using literature review and experts to distinguish and differentiate one nutrition problem from a similar or related problem. The Fehring models, used in nursing diagnosis validation research, are adopted to validate the SL nutrition diagnostic terms using experts and weighted inter-rater reliability ratios. In the first phase of validation research, diagnostic terms are validated by experts using the Diagnostic Content Validity Model (DCV). A Nutrition Diagnosis Validation Instrument (NDVI) is developed that contains …

The Adaptive Nature Of Impulsivity, Jeffrey R. Stevens, David W. Stephens

Department of Psychology: Faculty Publications

An old joke circulates among animal behavior instructors. One can, the joke goes, divide the topics of animal behavior into four Fs: fighting, fleeing, feeding, and reproduction. This somewhat tired joke carries considerable truth. Animals behaving in nature surely must make decisions about conflicts, predator avoidance, feeding, and mating. Male crickets, for example, are notoriously combative. Studies have shown, however, that they escalate fights in some situations and retreat to fight another day in others (Beaugrand, 1997; Parker, 1974; Parker & Rubenstein, 1981). Squirrels, like many small animals, respond to the presence or absence of protective cover; for example, they …

The Whitings’ Concepts Of Culture And How They Have Fared In Contemporary Psychology And Anthropology, Carolyn P. Edwards, Marianne Bloch

Department of Psychology: Faculty Publications

This article presents a brief intellectual biography of John and Beatrice Whiting, followed by an examination of five key ideas that they put forward to the fields of psychology and anthropology through their theoretical and empirical writings. These key ideas are (a) the assumption of the psychic unity of humankind, (b) the cultural learning environment, (c) the psychocultural model, (d) the synergistic relationship of the disciplines of psychology and anthropology, and (e) the role of mothers as agents of social change through child-rearing roles as well as through various other ways they guide change in the communities and learning environments …

Rational Decision Making In Primates: The Bounded And The Ecological, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Primates constantly face decisions that influence their survival and reproduction. Continue foraging in this tree or move on to another? Expose oneself to a hidden predator by straying from the group or enjoy the safety of having other potential victims nearby? Defend one’s territory from invaders or abandon it and seek a new home? In all of these cases, primates must trade off the costs and benefits associated with uncertain and delayed decision outcomes. The outcomes of these choices influence survival and reproduction, and natural selection should favor those individuals whose choices lead to the propagation of their genes.

The …

Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

A Clark’s nutcracker (Nucifraga columbiana) flies to the top of a pine tree and selects one of the many cones. She twists and pecks at the stem until the cone breaks free from the branch and, with one foot, holds the cone in the crotch of a branch. She then repeatedly hammers her long bill in between the scales of the cone. After forcing out one of the seeds, she tips her head back a bit, clicks the seed in her bill a few times, and closes her bill. A few minutes later, the shredded cone drops to …

Donor Payoffs And Other-Regarding Preferences In Cotton-Top Tamarins (Saguinus Oedipus), Jeffrey R. Stevens

Department of Psychology: Faculty Publications

Helping others at no cost to oneself is a simple way to demonstrate other-regarding preferences. Yet, primates exhibit mixed results for other-regarding preferences: chimpanzees and tamarins do not show these effects, whereas capuchin monkeys and marmosets preferentially give food to others. One factor of relevance to this no-cost food donation is the payoff to the donor. Though donors always receive the same payoffs regardless of their choice, previous work varies in whether they receive either a food reward or no food reward. Here, I tested cotton-top tamarins in a preferential giving task. Subjects could choose from two tools, one of …

Social Cognition And Interaction Training (Scit) For Individuals With Schizophrenia Spectrum Disorders In Outpatient Treatment Settings, Petra Kleinlein

Department of Psychology: Dissertations, Theses, and Student Research

The role of social cognition in severe mental illness (SMI) has gained much attention, especially over the last decade. The impact of deficits in socio-cognitive functioning has been found to have detrimental effects on key areas of day-to-day functioning in individuals with SMI, such as gaining and maintaining employment and overall experienced quality of life. Treatment of individuals with SMI is challenging, as the presentation of individual signs and symptoms is rather heterogeneous. There are several treatment approaches addressing deficits ranging from broader social and interpersonal functioning to neurocognitive and more intrapersonal functioning. As research in the domain of social …

Multiple Determinants Of Sexualized Behavior In Middle Childhood: A Developmental Psychopathology Perspective, Natasha Elkovitch

Department of Psychology: Dissertations, Theses, and Student Research

In order to adequately and appropriately intervene with children exhibiting problematic sexual behaviors, a comprehensive understanding of etiology is imperative. Although sexually abused children are observed engaging in more problematic sexual behaviors than their normative or psychiatric counterparts, it is clear that such behaviors may be the result of factors other than, or in addition to, sexual abuse. The goal of the present study was utilize a developmental psychopathology perspective in broadening our understanding of mechanisms associated with the development of problematic sexual behaviors in childhood. Participants for the study include 1, 149 children (51.8% female) drawn from the Longitudinal …

Mortality Patterns Of Army Chemical Corps Veterans Who Were Occupationally Exposed To Herbicides In Vietnam, Yasmin Cypel, Han Kang

Public Health Resources

PURPOSE: This research examined the risk of disease-related mortality of the Army Chemical Corps (ACC) veterans who handled/sprayed herbicides in Vietnam in comparison with their non-Vietnam veteran peers or U.S. men.

METHODS: Vital status was determined through December 31, 2005. All-cause mortality and cause-specific mortality were compared for individuals who served in Vietnam (n Z 2872) versus those who did not (n Z 2737). Similar analyses were completed on a subset of the original Vietnam cohort that consisted of individuals who either reported spraying herbicide (n Z 662) or not (n Z 811). The observed deaths for each …

Public Health Clinical Demonstration Project For Smoking Cessation In Veterans With Posttraumatic Stress Disorder, Eric A. Dedert, Sarah M. Wilson, Patrick S. Calhoun, Scott D. Moore, Kim W. Hamlett-Berry, Jean C. Beckham

Public Health Resources

Veterans with post traumatic stress disorder are at high risk for smoking and experience difficulty with smoking cessation. We designed this clinical demonstration project to provide a low-cost, feasibly implemented smoking cessation intervention that would maximize the number of smokers who accessed the intervention. Five hundred eighty-four veteran smokers were contacted by invitational letters. Interested veterans received follow-up telephone calls using standardized scripts offering three intervention resources: 1) a referral to the National Cancer Institute's Smoking Quitline, 2) web-based counseling, and 3) local Veteran Affairs pharmacologic treatment for smoking cessation. Twenty-three percent of survey recipients participated in the clinical program. …

Forming Bodies And Reforming Healthcare: The Co-Construction Of Information Technologies And Bodies Through The Imperative For Self Care, Scout Calvert

UNL Libraries: Faculty Publications

Care work and technological work are markedly striated by sex; the sites where they overlap are few. What happens when the labor of care meets up with information technologies? It makes good methodological sense to look at largely feminized environments that are also increasingly technological. Gender, Health, and Information Technology in Context, edited and with contributions by Ellen Balka, Eileen Green, and Flis Henwood, is a welcome contribution to the body of evidence about the socio-technical co-construction of technology, health, and gender. The volume houses nine studies, bookended by an astute introduction and conclusion by the editors. Each study …