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Articles 1 - 30 of 151
Full-Text Articles in Medicine and Health Sciences
Research News. Publications, 2020. Volume 4, Soumyajit Majumdar
Research News. Publications, 2020. Volume 4, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period October 1 through December 31, 2020
Health Insurance And The Undocumented Immigrant, Anja Diercks
Health Insurance And The Undocumented Immigrant, Anja Diercks
Honors Theses
The purpose of this thesis is to perform a comparative analysis on how seven different countries (USA, South Africa, Germany, England, Canada, France and Singapore) organize their healthcare system to cope with the issue of undocumented immigrants and whether or not these systems in place were “fair.” The thesis will also explore the possible ways the United States could change to be more inclusive and fairer in the world of healthcare and health insurance for the undocumented immigrant. A study on what fairness means both in ethical and economical terms is done to suggest a new basis of a fair …
Clinical Relevance Of Cancer Stem Cell Chemotherapeutic Assay For Recurrent Ovarian Cancer, Candace M. Howard, Nadim Bou Zgheib, Stephen Bush, Timothy Deeulis, Antonio Cortese, Antonio Mollo, Seth T. Lirette, Krista Denning, Jagan Valluri, Pier Paolo Claudio
Clinical Relevance Of Cancer Stem Cell Chemotherapeutic Assay For Recurrent Ovarian Cancer, Candace M. Howard, Nadim Bou Zgheib, Stephen Bush, Timothy Deeulis, Antonio Cortese, Antonio Mollo, Seth T. Lirette, Krista Denning, Jagan Valluri, Pier Paolo Claudio
Faculty and Student Publications
© 2020 Introduction: Disease recurrence and progression of ovarian cancer is common with the development of platinum-resistant or refractory disease. This is due in large part to the presence of chemo-resistant cancer stem cells (CSCs) that contribute to tumor propagation, maintenance, and treatment resistance. We developed a CSCs drug cytotoxicity assay (ChemoID) to identify the most effective chemotherapy treatment from a panel of FDA approved chemotherapies. Methods: Ascites and pleural fluid samples were collected under physician order from 45 consecutive patients affected by 3rd-5th relapsed ovarian cancer. Test results from the assay were used to treat patients with the highest …
Financial Analysis Of Dalbavancin For Acute Bacterial Skin And Skin Structure Infections For Self-Pay Patients, Adam G. Pizzuti, E. Yancy Murray, Jamie L. Wagner, Derek A. Gaul, Christopher M. Bland, Bruce M. Jones
Financial Analysis Of Dalbavancin For Acute Bacterial Skin And Skin Structure Infections For Self-Pay Patients, Adam G. Pizzuti, E. Yancy Murray, Jamie L. Wagner, Derek A. Gaul, Christopher M. Bland, Bruce M. Jones
Faculty and Student Publications
© 2020, The Author(s). Introduction: Acute bacterial skin and skin structure infections (ABSSSI) are an increasing cause of admission in the self-pay population. We previously reported that patients with ABSSSI discharged to receive dalbavancin showed a decreased length of stay (LOS) and total direct costs without increasing 30-day readmission rate. For patients who are financially eligible, a dalbavancin vial replacement program can offset costs. The objective of this study was to determine cost differences in treating ABSSSI in self-pay inpatients discharged to receive dalbavancin compared to standard of care (SOC). Methods: This retrospective cohort within a community health system compared …
Condylar Neck And Sub-Condylar Fractures: Surgical Consideration And Evolution Of The Technique With Short Follow-Up On Five Cases, Antonio Cortese, Antonio Borri, Marco Bergaminelli, Fabrizio Bergaminelli
Condylar Neck And Sub-Condylar Fractures: Surgical Consideration And Evolution Of The Technique With Short Follow-Up On Five Cases, Antonio Cortese, Antonio Borri, Marco Bergaminelli, Fabrizio Bergaminelli
Faculty and Student Publications
Condylar neck and sub-condylar fractures of the mandible are a frequent occurrence in maxillofacial surgery. The indication for surgical treatment of these fractures has changed over time, and several techniques have been developed with different results in the attempt to avoid the most worrisome adverse event, i.e., facial nerve injury. In this study, we present a new technique that combines an intraoral and a cutaneous pre-auricular access, which allows for easy and safe access to the surgical site, preventing facial nerve injury and avoiding surgical scars in high-impact aesthetic areas of the neck. Five consecutive patients affected by condylar neck …
A New Stilbene From Agonis Flexuosa Leaves And Verification Of Its Histamine Release Inhibitory Activity Using In Silico And In Vitro Studies, Rola M. Labib, Lourin G. Malak, Fadia S. Youssef, Samir A. Ross
A New Stilbene From Agonis Flexuosa Leaves And Verification Of Its Histamine Release Inhibitory Activity Using In Silico And In Vitro Studies, Rola M. Labib, Lourin G. Malak, Fadia S. Youssef, Samir A. Ross
Faculty and Student Publications
This study aimed to explore the phytoconstituents of Agonis flexuosa, F. Myrtaceae and its biological activity. A thorough phytochemical investigation of its leaves led to the isolation of one new stilbene glycoside; (Z)-2,3-dihydroxystilbene-5-O-β-D-glucoside (1), and fifteen known compounds identified as two stilbenes: (Z)-pinosylvin mono methyl ether (2) and (Z)-pinosylvin-3-O-β-D-glucoside (3); six flavanones: (2S)-pinostrobin (4), (2S)-strobopinin (5), (2S)-cryptostobin (6), (2S)-pinocembrin (7), (2S)-dimethylpinocembrin (8) and (2S)-dimethylstrobopinin (9); four flavonoids: quercetin (10), kaempferol-7-O-β-D-glucoside (11), quercetin-3-O-α-D-rhamnoside (12) and quercetin-3-O-β-D-glucoside (13), α-terpineol (14), β-sitosterol (15) and gallic acid (16). The structures of the isolated metabolites were elucidated based upon the interpretation of their 1D and …
Discovery Of A Remarkable Methyl Shift Effect In The Vanilloid Activity Of Triterpene Amides, Rosa Maria Vitale, Cristina Avonto, Danilo Del Prete, Aniello Schiano Moriello
Discovery Of A Remarkable Methyl Shift Effect In The Vanilloid Activity Of Triterpene Amides, Rosa Maria Vitale, Cristina Avonto, Danilo Del Prete, Aniello Schiano Moriello
Faculty and Student Publications
As part of a study on triterpenoid conjugates, the dietary pentacyclic triterpenoids oleanolic (2a) and ursolic acids (3a) were coupled with vanillamine, and the resulting amides (2b and 3b, respectively) were assayed for activity on the vanilloid receptor TRPV1. Despite a structural difference limited to the location of a methyl group in their conformationally rigid pentacyclic core, oleanoloyl vanillamide dramatically outperformed ursoloyl vanillamide in terms of potency (EC50 = 35 ± 2 nM for 2b and 5.4 ± 2.3 μM for 3b). Using molecular docking and dynamics, this difference was translated into distinct accommodation modes at the TRPV1 vanillyl ligand …
Redox-Responsive Nanoplatform For Codelivery Of Mir-519c And Gemcitabine For Pancreatic Cancer Therapy, Xiaofei Xin, Virender Kumar, Feng Lin, Vinod Kumar, Rajan Bhattarai, Vijaya R. Bhatt, Chalet Tan, Ram I. Mahato
Redox-Responsive Nanoplatform For Codelivery Of Mir-519c And Gemcitabine For Pancreatic Cancer Therapy, Xiaofei Xin, Virender Kumar, Feng Lin, Vinod Kumar, Rajan Bhattarai, Vijaya R. Bhatt, Chalet Tan, Ram I. Mahato
Faculty and Student Publications
Copyright © 2020 The Authors, some rights reserved. Desmoplastic and hypoxic pancreatic cancer microenvironment induces aberrant expression of miRNAs and hypoxia-inducible factor-1α (HIF-1α) responsible for gemcitabine (GEM) resistance. We demonstrated that miR-519c was down-regulated in pancreatic cancer and transfection of miR-519c in GEM-resistant pancreatic cancer cells inhibited HIF-1α level under hypoxia. We synthesized redox-sensitive mPEG-co-P(Asp)-g-DC-g-S-S-GEM polymer, with GEM payload of 14% (w/w) and 90% GEM release upon incubation with l-glutathione. We synthesized mPEGco- P(Asp)-g-TEPA-g-DC for complex formation with miRNA. Chemical modification of miR-519c with 2'-O-methyl phosphorothioate (OMe-PS) at 3' end enhanced its stability and activity without being immunogenic. Epidermal growth …
Real-World Patterns Of Everolimus Use In Patients With Metastatic Breast Cancer, Manvi Sharma, Zhigang Duan, Hui Zhao, Sharon H. Giordano, Mariana Chavez-Macgregor
Real-World Patterns Of Everolimus Use In Patients With Metastatic Breast Cancer, Manvi Sharma, Zhigang Duan, Hui Zhao, Sharon H. Giordano, Mariana Chavez-Macgregor
Faculty and Student Publications
© AlphaMed Press 2020 Background: There is limited literature on patterns of everolimus use and subsequent hospitalizations and emergency room (ER) visits in real-world clinical practice. In this study, we describe patterns of everolimus use and hospitalizations and ER visits in a large cohort of patients with breast cancer (BC). Materials and Methods: Patients with BC treated with everolimus were identified in the MarketScan database from 2009 to 2016. The pattern of everolimus use and frequency of associated ER visits and hospitalizations during treatment (between the first claim and 30 days after the last claim for everolimus) were identified. Descriptive …
Research News. Publications, 2020. Volume 3, Soumyajit Majumdar
Research News. Publications, 2020. Volume 3, Soumyajit Majumdar
Publications (2015-)
Publications that appeared during the period July 1 through September 30, 2020
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Research News. Grants, 2020. Volume 3, Soumyajit Majumdar
Grants (2015-)
Grants and contracts awarded during July - September 2020
R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark
R06. Identification Of The Cellular Pathways Targeted By Two Antifungal Natural Products Using Rna-Seq Analysis, Ameeta K. Agarwal, Siddharth K. Tripathi, Qin Feng, Ranga Rao Ravu, Xing-Cong Li, Alice M. Clark
Annual Poster Session 2020
Corresponding author (NCNPR): Ameeta Agarwal, aagarwal@olemiss.edu
R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan
R09. New Atractylon Derivatives Generated In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Jianping Zhao, jianping@olemiss.edu
R21. Preparation, Characterization And Stability Evaluation Of Ligand Anchored Primaquine Loaded Nanostructured Lipid Carrier Systems For Liver Targeting, Tabish Mehraj, Samir Senapati, Sushrut Marathe, Narendar Dudhipala, Babulal Tekwani, Soumyajit Majumdar
R21. Preparation, Characterization And Stability Evaluation Of Ligand Anchored Primaquine Loaded Nanostructured Lipid Carrier Systems For Liver Targeting, Tabish Mehraj, Samir Senapati, Sushrut Marathe, Narendar Dudhipala, Babulal Tekwani, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Tabish Mehraj, tmehraj.go@olemiss.edu
D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences
D01. Bms Department Poster, University Of Mississippi. Department Of Biomolecular Sciences
Annual Poster Session 2020
Corresponding author (BioMolecular Sciences): Candace Lowstuter, candacel@olemiss.edu
R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka
R17. Solid Crystal Suspensions Of Carbamazepine Using Hot-Melt Extrusion: A Solubility Enhancement Approach, Sagar Narala, Neeraja Komanduri, Dinesh Nyavanandi, Suresh Bandari, Michael A. Repka
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sagar Narala, snarala@go.olemiss.edu
R10. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-Pbd Analogs As Selective Cb2 Modulators Targeting Neurodegenerative Disorders, Meirambek Ospanov, David Mingle, Mohamed O. Radwan, Nicole M. Ashpole, Masami Otsuka, Samir A. Ross, Larry A. Walker, Abbas G. Shilabin, Mohamed A. Ibrahim
R10. First In Class (S,E)-11-[2-(Arylmethylene)Hydrazono]-Pbd Analogs As Selective Cb2 Modulators Targeting Neurodegenerative Disorders, Meirambek Ospanov, David Mingle, Mohamed O. Radwan, Nicole M. Ashpole, Masami Otsuka, Samir A. Ross, Larry A. Walker, Abbas G. Shilabin, Mohamed A. Ibrahim
Annual Poster Session 2020
Corresponding author (NCNPR): Mohamed A. Ibrahim, mmibrahi@olemiss.edu
R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar
R15. Development And Characterization Of Hot-Melt Extruded Ocular Inserts Of Moxifloxacin For Bacterial Keratitis, Ruchi Thakkar, Nagireddy Dumpa, Narendar Dudhipala, Michael A. Repka, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Ruchi Thakkar, rthakkar@go.olemiss.edu
R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar
R03. Hiv Tat Protein Activates Plasma Kallikrein-Kinin System In The Doxycycline-Inducible Astrocyte Specific Hiv-1 Tat Transgenic Mice, Logan Sneed, Fakhri Mahdi, Salahoddin Mohamed, Jason J. Paris, Zia Shariat-Madar
Annual Poster Session 2020
Corresponding author (BioMolecular Sciences): Logan Sneed, lsneed@go.olemiss.edu
D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour
D04. Department Of Pharmaceutics And Drug Delivery, Michael A. Repka, Walt G. Chambliss, Soumyajit Majumdar, S. N. Murthy, Seong Bong Jo, Chalet Tan, Mahavir Chougule, Eman Ashour
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug Delivery): Eman Ashour, eashour@olemiss.edu
R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan
R07. Identification Of Antifungal Bisphosphocholines From Medicinal Gentiana Species, Xing-Cong Li, Siyu Ren, Kejun Deng, Shi Qiu, Mei Wang, Bharathi Avula, Siddharth K. Tripathi, Melissa R. Jacob, Limin Gong, Wei Wang, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Xing-Cong Li, xcli7@olemiss.edu
D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar
D02. Ncnpr Activities At Coy Waller Complex, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Hemant Lata, Amira Wanas, Chandrani G. Majumdar
Annual Poster Session 2020
Corresponding author (NCNPR, School of Pharmacy): Mohamed M. Radwan, mradwan@olemiss.edu
R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar
R18. Preparation And Characterization Of Pegylated Nanostructured Lipid Carrier Systems For The Ocular Delivery Of Antineoplastic Agent, Sushrut Marathe, Narender Dudhipala, Soumyajit Majumdar
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sushrut Marathe, spmarath@go.olemiss.edu
R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka
R13. Formulation Development Of Loratadine Immediate-Release Tablets Using Hot-Melt Extrusion Coupled With 3d-Printing Technology, Sundus Hussain Omari, Eman A. Ashour, Mashan Amutairi, Rasha Elkanayati, Michael A. Repka
Annual Poster Session 2020
Corresponding author (Pharmaceutics and Drug delivery): Sundus Hussain Omari, somari@go.olemiss.edu
R23. Demographics And Outcomes Of Patients Hospitalized For Covid-19, Jonathan T. Newbaker, Scott S. Malinowski
R23. Demographics And Outcomes Of Patients Hospitalized For Covid-19, Jonathan T. Newbaker, Scott S. Malinowski
Annual Poster Session 2020
Corresponding author (University of Mississippi Medical Center): Jonathan T. Newbaker, jtnewbak@go.olemiss.edu
R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim
R11. Challenges And Future Directions Of Potential Natural Products Leads Against 2019-Ncov Outbreak, Meirambek Ospanov, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim
Annual Poster Session 2020
Corresponding author (NCNPR): Mohamed A. Ibrahim, mmibrahi@olemiss.edu
R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan
R08. Characterization Of Key Metabolites In Serum Of Fuzheng Huayu Phase Ii Clinical Trial, Yan-Hong Wang, Zachara Catchings, Bharathi Avula, Mei Wang, Huashi Bian, Ikhlas A. Khan
Annual Poster Session 2020
Corresponding author (NCNPR): Yan-Hong Wang, wangyh@olemiss.edu
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Novel Compounds In Fruits Of Coriander (Coşkuner & Karababa) With Anti-Inflammatory Activity, Renyikun Yuan, Zhenjie Liu, Jianping Zhao, Qin Qin Wang, Aiyuan Zuo, Liting Huang, Hongwei Gao, Qiongming Xu, Ikhlas A. Khan, Shilin Yang
Faculty and Student Publications
© 2020 Coriander, Coriandrum Sativum L., is one of the commonest food and medicinal plants in many countries, but its chemical ingredients and pivotal role in anti-inflammatory activity have not been fully explored. The present study aimed to identify new compounds in the fruits of coriander and explore their anti-inflammatory activity. The compounds were isolated by chromatographic seperations and identified using spectroscopic and spectrometric methods. RAW264.7 macrophage cells were used to detect the anti-inflammatory activity of the compounds via Griess assay, western blotting, ELISA, and flow cytometry methods. The study resulted in the discovery of four new compounds, which were …
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Marine Antithrombotics, Rohini Dwivedi, Vitor H. Pomin
Faculty and Student Publications
Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations …
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Validating A Predictive Model Of Cannabinoid Inheritance With Feral, Clinical, And Industrial Cannabis Sativa, Jonathan P. Wenger, Clemon J. Dabney, Mahmoud A. Elsohly, Suman Chandra, Mohamed M. Radwan, Chandrani G. Majumdar, George D. Weiblen
Faculty and Student Publications
© 2020 The Authors. American Journal of Botany published by Wiley Periodicals LLC on behalf of Botanical Society of America Premise: How genetic variation within a species affects phytochemical composition is a fundamental question in botany. The ratio of two specialized metabolites in Cannabis sativa, tetrahydrocannabinol (THC) and cannabidiol (CBD), can be grouped into three main classes (THC-type, CBD-type, and intermediate type). We tested a genetic model associating these three groups with functional and nonfunctional alleles of the cannabidiolic acid synthase gene (CBDAS). Methods: We characterized cannabinoid content and assayed CBDAS genotypes of >300 feral C. sativa plants in Minnesota, …