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Preparation Of Biodegradable Microspheres Useful As Carriers For Macromolecules, Patrick P. Deluca, Frantisek Rypacek
Preparation Of Biodegradable Microspheres Useful As Carriers For Macromolecules, Patrick P. Deluca, Frantisek Rypacek
Pharmaceutical Sciences Faculty Patents
A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.