Medicine and Health Sciences Commons^™

A Novel Impedance Biosensor For Measurement Of Trans-Epithelial Resistance In Cells Cultured On Nanofiber Scaffolds, Robert A. Schramm, Matthew H. Koslow, Deirdre A. Nelson, Melinda Larsen, James Castracane

Biological Sciences Faculty Scholarship

Nanofibrous scaffolds provide high surface area for cell attachment, and resemble the structure of the collagen fibers which naturally occur in the basement membrane and extracellular matrix. A label free and non-destructive method of assessing the interaction of cell tissue and scaffolds aids in the ability to discern the effective quality and magnitude of any scaffold modifications. Impedance cell spectroscopy is a biosensing method that employs a functional approach to assessing the cell monolayer. The electrical impedance barrier function of a cell monolayer represents the level of restriction to diffusion of charged species between all adjacent cells across an entire …

Chronic Arsenic Exposure In Nanomolar Concentrations Accelerates Senescent Phenotypes In Vitro, Heather M. Sabo

Biological Sciences

Arsenic is recognized as an environmental carcinogen, in which over 100 million individuals worldwide experience chronic exposure through contaminated drinking water. Arsenic exposure is linked to several health conditions, such as cancer, diabetes, skin lesions, immune dysfunction, and cardiovascular disease. Here we test the hypothesis that toxicants, such as arsenic, accelerate the program of senescence. Human (IMR-90) primary diploid fibroblasts were chronically exposed to arsenic at nanomolar concentrations and the impact on the expression of senescent-associated mRNAs was evaluated. IMR-90 cells were exposed either to untreated media or exposed to 130nM and 330nM AsCl3 supplemented media. RNA samples were extracted …

Hiv In New York City: An Overview Of Cultural And Social Factors Contributing To An Individual's Decision To Disclose Their Disease Status, Lindsey Riback

Public Health Undergraduate Program

will examine what effect cultural norms surrounding race and sexual orientation, as well as four specific social factors (alcohol use during sex, injection drug use, social support and the importance of religion) have on whether an HIV positive individual, specifically an urban homosexual male, chooses to disclose their disease status. This paper will discuss those cultural norms and social factors through the AIDS Risk Reduction Model, available literature, and the data collected by the National Institute of Mental Health for the Positive Connections intervention trial. The data for this paper were pulled from the larger study, and only the 171 …

Estimating Environmental Emissions From Produce Waste Redistribution In The Capital Region, Molly Fleming

Public Health Undergraduate Program

Every year in New York’s Capital Region a large amount of food goes to waste, and about one-half of produce (fruits and vegetable) that is produced is wasted. However, many organizations in the Capital Region have put in efforts to redistribute this surplus produce to the food insecure to help improve their diets. This project looked at how that surplus produce is redistributed to the food insecure in the Capital Region, the life cycle energy consumption and associated greenhouse gas emissions of that redistribution, and how that redistribution could be improved. Working with local partners through survey data collection, interviews, …

Visualizing The Diffusion Of Digital Mammography In New York State, Francis P. Boscoe, Xiuling Zhang

Epidemiology & Biostatistics Faculty Scholarship

Digital mammography saw rapid adoption during the first decade of the 2000s. According to data maintained by the Food and Drug Administration, which regulates mammography machines, fewer than 1 percent of the machines in 2001 were digital. By 2014, this figure had risen to 94%. We were interested in identifying the times and locations where the technology was introduced within the state of New York as a way of illustrating the uneven introduction of this technology. While the diffusion of medical innovation has been well-studied, there have not been many instances where maps or geographic information science methods have been …

Early Diagnosis And Intervention For Young Children With Autism Spectrum Disorder In New York State, Grace Ester Caroline Korompis

Health Policy, Management & Behavior Theses & Dissertations

This study examined the prevalence of autism spectrum disorder (ASD), analyzed the trends, assessed children’s sociodemographic characteristics and examined timing of ASD diagnosis among children who enrolled in the New York State Early Intervention Program (NYSEIP).

Secondary data from the New York State Early Intervention data systems were used. The systems include NYEIS (New York State Early Intervention System), a centralized web-based system that electronically manages the NYSEIP administrative tasks and was designed to support the NYSEIP's services, and the legacy data system: KIDS (Kids Integrated Data System). The time-trend design employed in this study was a form of longitudinal …

Improving Hiv Outcomes In Pakistan : The Interaction Between Politics, Power And Implementation, Hina Khalid

Legacy Theses & Dissertations (2009 - 2024)

HIV contributes to the highest number of deaths from infectious diseases in low-income countries. In this three-paper dissertation, using the case of Pakistan, I focus on understanding how the exercise of power by actors at three different levels of the health system, individual, program and societal, influences policy implementation and shapes HIV program outcomes. The objective is to improve HIV service provision thereby achieving improved health policy outcomes. I adopt a mixed-methods approach and use quantitative (logit regression) and qualitative techniques (content analysis of newspapers and semi-structured interviews). One paper tests the role played by network operators in influencing condom …

Association Between Hiv And Violence Among Female Commercial Sex Workers In Ukraine : Analysis Of Bio-Behavioral Surveillance Conducted In 2015-2016, Ganna Momotyuk

Legacy Theses & Dissertations (2009 - 2024)

A cross-sectional analysis investigated the association between HIV and violence in female commercial sex workers (FCSW) in Ukraine between 10/2015 and 01/2016. Methods: 3,885 FCSW from a total of 4,300 were questioned about behavioral and social demographics and tested for HIV in mobile testing van. Results: of the 3,885 respondents, 5.89% were HIV positive, and 47.00% had experienced violence. We tested for and found that drug use was an effect modifier for the association between HIV and violence. Analyses were stratified by injecting drug use and no injecting drug use. High risk for HIV was found in the non-IDU stratum …

Lncrna Ak001796 Is Essential For The Survival Of Aggressive Breast Cancer Cells, Sumayya Adib Al-Chalabi

Legacy Theses & Dissertations (2009 - 2024)

Abstract:

Does What You Think You Feel, Impact What You Actually Eat? : An Examination Of Alexithymia, Interoceptive Awareness, And Loss Of Control Eating In Young Women, Lisa Marie Anderson

Legacy Theses & Dissertations (2009 - 2024)

Affect regulation theories posit that loss of control (LOC) and binge eating are maintained via an emotion regulation process, through which eating relieves negative affect and aversive mood states. LOC has been identified as a key binge eating characteristic associated with psychopathology and poor psychological outcomes. As such, maladaptive emotion regulation has been identified as a central risk factor for binge eating, as theories posit that individuals binge eat in response to negative mood states. However, empirical studies testing the link between induced negative mood and subsequent food intake in people with LOC and binge eating have yielded inconsistent findings. …

Development And Characterization Of Novel Anti-Bat Monoclonal Antibodies For Studying Bat Immunity, Cailyn Cowan

Legacy Theses & Dissertations (2009 - 2024)

Abstract

Using Technologies To Support The Social And Academic Engagement Of Young People With Cancer, Owen Michael Donovan

Legacy Theses & Dissertations (2009 - 2024)

Situated in the larger questions of how to support the educational engagement and positive psychosocial development of young people with cancer, the purpose of this exploratory study was to address gaps in the literature and build understanding of how young people use digital and Internet-connected technologies in ways that support their social and academic engagement. Through a multiple case-design, I examined the school-based and everyday (outside of school) technology uses of five young people. This study found that the cancer experience changed or reframed a young person’s motivational engagement with school. Doing well academically was a sign of a normalcy …

Socio-Demographic Determinants Of Racial Disparities In Stage At Diagnosis Of Prostate Cancer In New York State, Christophe Maxime Fokoua Dongmo

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Impact Of Substance Use And Overweight Status On The Relationship Between Domestic Violence And Bullying, Marcie Fraser

Legacy Theses & Dissertations (2009 - 2024)

Domestic violence has been shown to increase the risk of bullying behavior among youth. Substance use and excess weight have also been linked to bullying behaviors. The purpose of this study was to determine what anti-bullying interventions have been implemented throughout the United States, and to identify the role of three risk factors (domestic violence, excessive weight or substance use) on bullying behaviors. For this study domestic violence will be defined as experiencing domestic violence or witnessing inter-parental domestic violence. A literature review (Study 1) was conducted to identify studies and summarize interventions aimed at reducing bullying behaviors among middle-school …

Maltreatment Related Outpatient Visits And Hospitalizations Among Children In New York State, 2011-2014, Lusine Ghazaryan

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

The Association Of Comorbid Chronic Physical Conditions And Psychological Illness With Health Care Utilization In Middle-Aged And Older People, Allison Houston

Legacy Theses & Dissertations (2009 - 2024)

Abstract

A Brief Motivational Intervention For Marijuana Use In College Students, Vivian S. Hwang

Legacy Theses & Dissertations (2009 - 2024)

The prevalence of marijuana use has risen among young adults, and marijuana is

Hepatitis C Status Awareness And Test Results Confirmation Among People Who Inject Drugs In Ukraine, Olena Iakunchykova

Legacy Theses & Dissertations (2009 - 2024)

Background. Hepatitis C virus (HCV) positivity is frequently found in people who inject drugs (PWID). The prevalence of HCV in this population in Ukraine is estimated at 71%. As treatment for HCV infection becomes more available, it is important to know what modifiable factors are related to testing, linkage to care and treatment.

Factors Asociated With Mental Health Help-Seeking Attitudes Among University Students In South Korea, Hee Chul Kim

Legacy Theses & Dissertations (2009 - 2024)

The current study investigated factors associated with mental health help-seeking attitudes among university students in South Korea. In particular, the study examined the moderating effects of culturally relevant factors (religiosity, social support, social stigma, and self-stigma) on the relationship between psychological distress and help-seeking attitudes and the mediating effect of stigma (social and self) on the association between psychological distress and help-seeking attitudes. A total of 240 students at 4 universities in South Korea completed in-class surveys in Spring 2016. Data was analyzed using a series of multiple regressions, hierarchical moderated multiple regression, and 3-step mediation regression. Results indicated that …

Impact Of Foreign Born East Asian Density On Liver Cancer Incidence Rate Among Neighborhoods In New York City During 2009-2013 : Multilevel Analysis, Sangwon Lee

Legacy Theses & Dissertations (2009 - 2024)

Objective: To investigate the impact of the density of foreign born Asian population on geographical incidence rate of liver cancer in New York City during 2009 – 2013 in order to find specific geographic areas in NYC where liver cancer intervention should be targeted.

Exploring The Role Of Escapism In The Dsm-V Criteria For Internet Gaming Disorder : A Meta-Analytic Investigation, Yeonggeul Lee

Legacy Theses & Dissertations (2009 - 2024)

Internet gaming disorder (IGD) has been included in the DSM-5 in a preliminary endorsement of excessive video gaming as a behavioral disorder. Further research is required to validate IGD because some criteria are controversial in diagnostic accuracy. Escapism is one such criterion. Despite some research evidence of escapism as the strongest motivational predictor of IGD, recent investigations found that the escapism criterion is highly questionable. Because of the inclusion of escapism in initial IGD measures, previous studies have produced evidence of escapism as a predictor of IGD owing to a tautology. Thus, the present study examined the effect of gaming …

Cumulative Risk And Chinese Adolescent Problematic Internet Use : The Mediating Role Of Self-Esteem, Xian Li

Legacy Theses & Dissertations (2009 - 2024)

A decade of research has documented the adverse effect of multiple ecological risks on adolescent problematic Internet use (PIU), yet existing research provides rather segmental explanations, and few studies offer a comprehensive and integrated account. A better theoretical and empirical understanding of the associations of multiple ecological risks and PIU, as well as the underlying mechanisms, could help inform intervention practices and policies to mitigate adolescent PIU.

Early Diagnosis And Intervention For Young Children With Autism Spectrum Disorder In New York State, Grace Esther Caroline Korompis

Legacy Theses & Dissertations (2009 - 2024)

This study examined the prevalence of autism spectrum disorder (ASD), analyzed the trends, assessed children’s sociodemographic characteristics and examined timing of ASD diagnosis among children who enrolled in the New York State Early Intervention Program (NYSEIP).

Viral Suppression Among Older Persons Living With Diagnosed Hiv Infection (Plwdhi) With Multimorbidity : The Role Of Healthcare Setting, Health Literacy, And Health Knowledge (Mmp 2009-2014), Doris Ogechukwu Maduka

Legacy Theses & Dissertations (2009 - 2024)

For persons living with diagnosed HIV infection (PLWDHI) 50 years of age and older, in addition to living with diagnosed HIV infection, they are also at risk for age-related chronic conditions. Optimal management of these conditions in addition to HIV is needed if they hope to achieve positive health outcomes such as achieving durable viral suppression, which is the goal for persons receiving HIV treatment. For these patients, having adequate health related information, and the ability to access and navigate the healthcare system, would help them stay engaged and maintain adherence to HIV care. Factors that have been found to …

Mortality One-Year Post Stroke : What Matters? : An Exploratory Study Of A Cohort In New York State, Zainab Magdon-Ismail

Legacy Theses & Dissertations (2009 - 2024)

Background/Purpose: Stroke is one of the leading causes of mortality and serious long-term disability in the United States. However, there are few studies evaluating factors associated with long-term outcomes among stroke survivors.

Essays On Health Disparities And Income-Related Health Inequality In Sub-Saharan Africa, Marshall Makate

Legacy Theses & Dissertations (2009 - 2024)

This dissertation comprises of five empirical essays. Essay one assesses the impact of prenatal care quality and its components on child mortality using nationwide data from the Zimbabwe Demographic and Health Surveys (ZDHS), 1999-11. Results indicate that increasing prenatal care quality by one unit improves neonatal, infant and under-five survival by about 42.33, 30.86, and 28.65%, respectively and all statically significant at the 1% level.

Discovering Small Molecule Inhibitors Targeted To Ligand-Stimulated Rage-Diaph1 Signaling Transduction, Jinhong Pan

Legacy Theses & Dissertations (2009 - 2024)

The receptor of advanced glycation end product (RAGE) is a multiligand receptor of the immunoglobulin superfamily of cell surface molecules, which plays an important role in immune responses. Full-length RAGE includes three extracellular immunoglobulin domains, a transmembrane domain and an intracellular domain. It is a pattern recognition receptor that can bind diverse ligands. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms. It is found that calgranulin binding to the C1C2 domain or AGEs binding to the V domain activates extracellular signaling, which triggers interactions of …

Mediating And Moderating Factors Of The Relationship Between Sexual Orientation And Eating Pathology And Body Satisfaction In Sexual Minority And Heterosexual Men, Andrea Denae Murray

Legacy Theses & Dissertations (2009 - 2024)

Most research on body image and disordered eating has focused largely on women, as women are at higher risk than men for eating disorders. In recent years research has revealed that men are at increasing risk for these outcomes, especially as the ideal male body represented in media images and therefore frequently internalized among men is becoming so lean and muscular as to make it very difficult for most men to realistically achieve. Sexual minority men in particular have been found to be at increased risk for body dissatisfaction, body shame, and disordered eating than their heterosexual counterparts. The research …

Pregnant Women With Congenital Heart Disease : Pregnancy Outcomes And Proximity To Care, Lauren Schlichting

Legacy Theses & Dissertations (2009 - 2024)

The number of adults living with congenital heart disease (CHD) now surpasses the number of children with the condition due to medical advances and the resulting increased survival rates in infants. However, much of the research focusing on proximity to specialty care for individuals with this complex condition has been with children. Pregnant women with these serious malformations are of particular concern, due to the stress of pregnancy on the circulatory system and the increase in risk for delivery complications. Few studies to date have described the healthcare utilization patterns at delivery and travel burden to specialty care for this …

Genetic Counselor Workforce Trends In The United States : 2002 To 2016, Charlene J. Schulz

Legacy Theses & Dissertations (2009 - 2024)

The purpose of this study was to identify and measure trends in genetic counselor (GC) workforce supply in the United States from 2002 to 2016. Using data collected biennially from the National Society of Genetic Counselors’ Professional Status Survey (PSS), I calculated overall percent change in GC employment across specific work settings over the past 14 years. I also measured change in the relative percentage of GCs who provide direct patient counseling (i.e. clinical GCs) to determine if the percentage of clinical GCs decreased over time. Analyses were performed to determine if associations existed between GC work settings and 1) …