Medicine and Health Sciences Commons^™

Inadequate Physician Knowledge Of The Effects Of Diet On Blood Lipids And Lipoproteins., Mary M. Flynn, Chris N. Sciamanna, Kevin C. Vigilante

College of Population Health Faculty Papers

BACKGROUND:To assess the nutrition knowledge of physicians on the basic effects of diet on blood lipids and lipoproteins.

METHODS:Anonymous mailed dietary knowledge surveys to 6000 randomly selected physicians in the United States licensed in either Internal Medicine or Cardiology.RESULTS:Response rate: 16% (n = 639). Half of the physicians did not know that canola oil and 26% did not know olive oil were good sources of monounsaturated fat. Ninety-three percent (84% of cardiologists vs. 96% of internists; p < 0.001) did not know that a low-fat diet, in general, would increase blood triglycerides. Approximately three-quarters (70% of cardiologists vs. 77% of internists; p < 0.01) did not know a low-fat diet would decrease HDL-c and almost half (45%) thought that a low-fat diet would not change HDL-c.

CONCLUSIONS:If physicians are to implement dietary and cholesterol management guidelines, they will likely need to become more knowledgeable about nutrition.

Jefferson Alumni Bulletin – Volume 53, Number 1, December 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 53, Number 1, December 2003 The Dean’s Column by Thomas J. Nasca ’75, Page 4 Early Anesthesia Research and Jeffersonians, Page 6 Grunwald Appointed Chair of Anesthesiology, Page 7 Marone Honored for His Involvement in Establishing the Spinal Cord Injury Center, Page 8 Alumni Are Involved in the Search for the Next University President, Page 9 The Fortunate Beneficiaries of Our Education, by Richard Wenzel ’65, Alumni Achievement Award Winner, Page 14 Reunions, Clinic Talks, the Alumni Banquet, Pages 15–32

Provider-Caregiver Interactions: Evaluation And Use Of The Therapeutic Relationship Index For Caregiver Interventions, Yeon Kyung Chee, Marie P. Dennis, Laura N. Gitlin

Center for Applied Research on Aging and Health Research Papers

No abstract provided.

Embryonic Origins Of A Motor System: Motor Dendrites Form A Myotopic Map In Drosophila, Matthias Landgraf, Victoria Jeffrey, Miki Fujioka, James B. Jaynes, Michael Bate

Department of Biochemistry and Molecular Biology Faculty Papers

The organisational principles of locomotor networks are less well understood than those of many sensory systems, where in-growing axon terminals form a central map of peripheral characteristics. Using the neuromuscular system of the Drosophila embryo as a model and retrograde tracing and genetic methods, we have uncovered principles underlying the organisation of the motor system. We find that dendritic arbors of motor neurons, rather than their cell bodies, are partitioned into domains to form a myotopic map, which represents centrally the distribution of body wall muscles peripherally. While muscles are segmental, the myotopic map is parasegmental in organisation. It forms …

Caregiver Strategy Use To Contend With Cognitive And Functional Decline In Persons With Dementia , Laura N. Gitlin, Marie P. Dennis, Walter W. Hauck, Laraine Winter, Sandy Schinfeld

Center for Applied Research on Aging and Health Research Papers

No abstract provided.

Overview, David B. Nash

College of Population Health Faculty Papers

No abstract available.

Transcriptional Inhibition Of Type I Collagen Gene Expression In Scleroderma Fibroblasts By The Antineoplastic Drug Ecteinascidin 743., Natalia Louneva, Biagio Saitta, David J Herrick, Sergio A. Jimenez

Department of Medicine Faculty Papers

We previously showed that COL1A1 expression is up-regulated at the transcriptional level in systemic sclerosis (SSc) fibroblasts and that the CCAAT-binding factor (CBF) is involved in this increased expression. Ecteinascidin 743 (ET-743) is a chemotherapeutic agent that binds with sequence specificity to the minor groove of DNA and inhibits CBF-mediated transcriptional activation of numerous genes. Therefore, we examined the effects of ET-743 on the increased COL1A1 expression in SSc fibroblasts. The drug caused a potent and dose-dependent inhibition of type I collagen biosynthesis, which reached 70-90% at 700 pM without affecting cell viability. The same drug concentration caused 60-80% reduction …

Nurses Alumni Association Bulletin, Fall 2003, Paula Levine, Elizabeth K. Prisnock, Sally H. Wagner, John J. Wagner

Nursing Alumni Bulletins

2003 - 2004 Meeting Date Calendar

2004 Annual Luncheon & Meeting Notice

Officers, Committee Chairs, Satellite and Volunteers

Bulletin Publication Committee

The President's Message

Treasurer's Report

Resume of Minutes

Clinical Nursing Practice And Patient Outcomes Endowed Fund

JMC Appreciation Award 1978

Office News

Committee Reports

• Relief Trust Fund
• Satellite - Harrisburg Satellite Area
• Scholarship
• Social
• Nominating
• Bulletin
• Development

Annual Giving

News About Graduates

Memories

Odds & Ends

Janet C. Hindson Award Recipients and Nominees

Janet C. Hindson Award Qualifications

Happy Birthday, To Be 80 or more

In Memoriam, Names of Deceased Graduates

50th Anniversary Class

Luncheon Attendees

Center page

Class …

Il-7 Enhances Peripheral T Cell Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation., Onder Alpdogan, Stephanie J Muriglan, Jeffrey M Eng, Lucy M Willis, Andrew S Greenberg, Barry J Kappel, Marcel R M Van Den Brink

Department of Medical Oncology Faculty Papers

We used clinically relevant murine allogeneic bone marrow transplantation (BMT) models to study the mechanisms by which IL-7 administration can improve posttransplant peripheral T cell reconstitution. After transplant we could distinguish two populations of mature donor T cells: (a) alloreactive T cells with decreased expression of CD127 (IL-7 receptor alpha chain) and (b) nonalloreactive T cells, which express CD127 and undergo homeostatic proliferation. IL-7 administration increased the homeostatic proliferation of nonalloreactive T cells, but had no effect on alloreactive T cells and the development of graft-versus-host disease. Allogeneic transplant of purified hematopoietic stem cells and adoptive transfer of thymocytes into …

Global Partnerships To Strengthen The Evidence Base For Nursing, Beth Ann Swan Phd, Crnp, Naeema H. Al-Gasseer Phd, Rn, Norma M. Lang Phd, Rn, Faan, Frcn

College of Nursing Faculty Papers & Presentations

There is a growing emphasis on building the evidence base as governments, health systems, practitioners, and consumers, nationally and globally, search for ways to improve health care outcomes and enhance the efficiency and effectiveness of health services.

Nurses and midwives constitute the largest group of health service providers in the majority of health systems around the globe.

The WHO Global Advisory Group on Nursing and Midwifery recommended that WHO should form strategic alliances with partners to identify uniform core indicators and build a solid body of evidence to inform national health policies, particularly in the area of cost-effective nursing and …

Jefferson Alumni Bulletin – Volume 52, Number 4, September 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 4, September 2003 The Dean's Column by Thomas J. Nasca ’75, page 4 The Orbit of My Eye an essay by Risa Ravitz ’05, page 8 Students Teach Underserved Children to Read, in Addition to Providing Medical Care for the Parents, page 10 Combining Two Types of Radiation Therapy to Improve the Treatment of Brain Cancer, page 17 Landmark Study of Early Surgery for Epilepsy, page 17 Research on How to Improve Physician Empathy , page 18 Using Plants to Produce Antibodies Against Rabies, page 19 HIV's Escape Route from Drugs and Vaccines …

Organizational Characteristics And Restraint Use For Hospitalized Nursing Home Residents., Meg Bourbonniere, Neville E. Strumpf, Lois K. Evans, Greg Maislin

College of Nursing Faculty Papers & Presentations

OBJECTIVES: To examine the effect of organizational characteristics on physical restraint use for hospitalized nursing home residents.

DESIGN: Secondary analysis of data obtained between 1994 to 1997 in a prospective phase lag design experiment using an advanced practice nurse (APN) intervention aimed at reducing physical restraint for a group of hospitalized nursing home residents.

SETTING: Eleven medical and surgical units in one 600-bed teaching hospital.

PARTICIPANTS: One hundred seventy-four nursing home residents aged 61 to 100, hospitalized for a total of 1,085 days.

MEASUREMENTS: Physical restraint use, APN intervention, age, perceived fall risk, behavioral phenomena, perceived treatment interference, mental state, …

Characterization Of Mutations And Loss Of Heterozygosity Of P53 And K-Ras2 In Pancreatic Cancer Cell Lines By Immobilized Polymerase Chain Reaction, James Butz, Eric Wickstrom, Jeremy Edwards

Department of Biochemistry and Molecular Biology Faculty Papers

Background

The identification of known mutations in a cell population is important for clinical applications and basic cancer research. In this work an immobilized form of the polymerase chain reaction, referred to as polony technology, was used to detect mutations as well as gene deletions, resulting in loss of heterozygosity (LOH), in cancer cell lines. Specifically, the mutational hotspots in p53, namely codons 175, 245, 248, 249, 273, and 282, and K-ras2, codons 12, 13 and 61, were genotyped in the pancreatic cell line, Panc-1. In addition LOH analysis was also performed for these same two genes in Panc-1 by …

Children With Disturbances In Sensory Processing: A Pilot Study Examining The Role Of The Parasympathetic Nervous System., Roseann C. Schaaf, Lucy Jane Miller, Duncan Seawell, Shannon O'Keefe

Department of Occupational Therapy Faculty Papers

This study was a preliminary investigation of parasympathetic nervous system (PNS) functioning in children with disturbances in sensory processing. The specific aims of this study were to (1) provide preliminary data about group differences in parasympathetic functions, as measured by the vagal tone index, between children with disturbances in sensory processing and those without; (2) determine effect size and power needed for future studies; and (3) to lay the foundation for further examination of the relations of parasympathetic functioning and functional behavior in children with disturbances in sensory processing. Participants were 15 children, nine with disturbances in sensory processing and …

Filling The Gaps In Physician Communication. The Role Of The Internet Among Primary Care Patients, Chris N. Sciamanna, Melissa Clark, Joseph Diaz, Stephanie Newton

College of Population Health Faculty Papers

BACKGROUND:

Millions of people use the Internet as a source for health information yet little is understood about how the use of the Internet for health information is related to the doctor-patient relationship.

OBJECTIVE:

We conducted the present study to understand the association between one’s interest in using the Internet for general and quality-oriented health information and attitudes about one’s communications with health care provider(s).

DESIGN:

Cross-sectional survey.

SETTING:

Four community-based primary care practices in Rhode Island.

MEASUREMENTS:

A single self-administered survey included items to measure: interest in using the Internet to look for general and quality-oriented information and a …

Care Management For Persistent Pain: An Introduction, Christine W. Hartmann, Neil I. Goldfarb, Susan S. Kim, Bhaskar R. Nuthulaganti, Raafat Seifeldin

College of Population Health Faculty Papers

Persistent pain is a frequently occurring condition with significant economic, clinical, and humanistic implications, for both individuals and society. Current literature, however, points to unresolved issues with regard to its identification, assessment, diagnosis, and treatment, and a number of suggestions have been made for improving the quality of care for pain sufferers. Because persistent pain shares many of the salient features of other chronic conditions such as diabetes and congestive heart failure, it is reasonable to believe that the adoption of a coordinated approach to care management could substantially improve the quality of care. Several strategiesincluding identification, appropriate referral, education, …

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 3, June 2003 Dean's Column by Dean Thomas J. Nasca ’75, page 4 Update on Transplant Surgery, page 5 The New Jefferson Hospital for Neuroscience and Farber Institute for Neurosciences, page 6 Researchers Show That Human Neural Stem Cells Can Become Dopamine-Making Brain Cells in the Lab, page 8 Evidence of Greater Sensitivity to Addictive Drugs in Adolescence, page 8 New Hope for Patients with Late Stage Parkinson's, page 10 Above and Beyond the Call: Three Alumni Heroes, page 11 The Mother in The Gross Clinic: A Medical Explanation of Her Hand, page …

Systemic Sclerosis: Current Views Of Its Pathogenesis., Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities. Clinically, SSc is very heterogeneous, encompassing a spectrum ranging from mild limited forms of skin sclerosis with minimal internal organ involvement to severe skin and multiple internal organ fibrosis. Mortality and morbidity in SSc are very high and are directly related to the extent of the fibrotic and microvascular alterations. A better understanding of the pathogenesis of this incurable disorder will help to better target and design effective …

2003 Commencement For College Of Health Professions

Jefferson College of Nursing Commencements

No abstract provided.

European Mistletoe/Iscador® Faq , Clinic Staff

Topics in Integrative Medicine

Mistletoe (Viscum album) may be the most commonly used complementary cancer therapy in Europe today. Background information and important questions are presented.

The Review - Spring 2003

Jefferson Review

In This Issue

• 3 Message From the Dean
• 4 Special Occasions
• 5 Gail Seygal (OT ’86) - Animal Touch
• 6 War Stories
• 6 JAVA Night
• 8 Federal Stafford and Consolidation Loans
• 9 OT Students Visit Cuba
• 10 Penny Kroll, New PT Chair
• 10 New DPT
• 11 TJU Nursing Reimbursement
• 11 Lab Sciences Changes Its Name
• 12 Jeff-At-Night
• 12 Lambda Nu
• 13 Alumni Events
• 19 JCHP Awards
• 21 Student Life Award
• 22 PT Convocation
• 23 JCHP Commencement

Mindfulness-Based Stress Reduction Lowers Psychological Distress In Medical Students, Steven Rosenzweig Md, Diane K. Reibel, Jeffrey M. Greeson, George C. Brainard, Mohammadreza Hojat

Marcus Institute of Integrative Health Faculty Papers

Background: Medical students confront significant academic, psychosocial, and existential stressors throughout their training. Mindfulness-based stress reduction (MBSR) is an educational intervention designed to improve coping skills and reduce emotional distress.

Purpose: The purpose of this study was to examine the effectiveness of the MBSR intervention in a prospective, nonrandomized, cohort-controlled study.

Methods: Second-year students (n = 140) elected to participate in a 10-week MBSR seminar. Controls (n = 162) participated in a didactic seminar on complementary medicine. Profile of Mood States (POMS) was administered preintervention and postintervention.

Results: Baseline total mood disturbance (TMD) was greater in …

The Jeffcare Preceptor Model For Asthma: A Primary Care Physician Tutorial Training Model, Jeffrey L. Lenow, Robert Bales, Stanton N. Smullens

College of Population Health Faculty Papers

The societal and economic impact of asthma is a well-documented phenomenon in this country. Despite improved knowledge and techniques of care, there have been signs of worsening morbidity/mortality and a seeming disconnect between physician and patients as regards communication of care strategies. In an attempt to fashion innovative educational strategies to enhance primary care physician (PCP) and caregiver efficiencies in improving patient outcomes (clinical and financial), the "Preceptor" model of one-to-one PCP/asthma specialist has been developed. Review of utilization and prescribing data demonstrates a clear pattern of statistically significant cost improvement in the aggregate care setting, as well as improved …

Jefferson Alumni Bulletin – Volume 52, Number 2, March 2003

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 52, Number 2, March 2003 Dean's Column by Dean Thomas J. Nasca ’75, page 4 Ushering in the Modern Era in Surgery: the Heart-Lung Machine, Developed Here, 50 Years Ago, page 8 One of the "Seven Greatest Doctors in America", page 9 Pulmonary/Critical Care Fellows Win National Competition, Besting 88 Other Medical Schools, page 10 Two Medical Students Win AOA National Awards , page 11 Laparoscopic Radical Prostatectomy Is First in the Delaware Valley, page 12 Jefferson Surgeons Perform Philadelphia’s First Incompatible Kidney Transplant, page 12 Chinese Health Information Center Receives $1.5 Million to Expand, …

Transfection Of Il-10 Expression Vectors Into Endothelial Cultures Attenuates Alpha4beta7-Dependent Lymphocyte Adhesion Mediated By Madcam-1., Makoto Sasaki, Paul Jordan, Jeff Houghton, Xianmin Meng, Makoto Itoh, Takashi Joh, J Steven Alexander

Department of Dermatology and Cutaneous Biology Faculty Papers

BACKGROUND: Enhanced expression of MAdCAM-1 (mucosal addressin cell adhesion molecule-1) is associated with the onset and progression of inflammatory bowel disease. The clinical significance of elevated MAdCAM-1 expression is supported by studies showing that immunoneutralization of MAdCAM-1, or its ligands reduce inflammation and mucosal damage in models of colitis. Interleukin-10 (IL-10) is an endogenous anti-inflammatory and immunomodulatory cytokine that has been shown to prevent inflammation and injury in several animal studies, however clinical IL-10 treatment remains insufficient because of difficulties in the route of IL-10 administration and its biological half-life. Here, we examined the ability of introducing an IL-10 expression …

Evaluation Of The Penn Macy Initiative To Advance Academic Nursing Practice, Lois K. Evans Dnsc, Rn, Faan, Beth Ann Swan Phd, Crnp, Norma E. Lang Phd, Rn, Faan, Frcn

College of Nursing Faculty Papers & Presentations

In the realm of academic practice, schools of nursing, especially those in research-intensive environments, face a dilemma. These schools are in the best position to shape nursing science through research based in academic practice. Yet they also face formidable challenges to maintaining balance among the three legs of the tripartite mission. The questions of whether and how to commit resources to move forward their academic practice agendas are not answered easily. The Penn Macy Initiative to Advance Academic Nursing Practice aimed to assist such schools in their development of academic practices through a week-long intensive institute and 1 year of …

Regulation Of Human Col9a1 Gene Expression. Activation Of The Proximal Promoter Region By Sox9., Ping Zhang, Sergio A. Jimenez, David G Stokes

Department of Medicine Faculty Papers

The COL9A1 gene contains two promoter regions, one driving expression of a long alpha1(IX) chain in cartilage (upstream) and one driving expression of a shorter chain in the cornea and vitreous (downstream). To determine how the chondrocyte-specific expression of the COL9A1 gene is regulated, we have begun to characterize the upstream chondrocyte-specific promoter region of the human COL9A1 gene. Transient-transfection analyses performed in rat chondrosarcoma (RCS) cells, human chondrosarcoma (HTB) cells, and NIH/3T3 cells showed that the COL9A1 promoter was active in RCS cells but not HTB or NIH/3T3 cells. Inclusion of the first intron had no effect on promoter …

Development And Validation Of A Professional Behavior Assessment., Kristie Koenig, Caryn Johnson, Cathleen K Morano, Joseph P Ducette

Department of Occupational Therapy Faculty Papers

Allied health students must quickly socialize into a professional role as they transition from classroom to clinic. In addition to skill development, students must exhibit a host of professional behaviors that facilitate successful interaction with patients, families, and colleagues. There is a need for a valid, reliable assessment of professional behaviors that contribute to clinical competence. This study reports on the development and validation of a professional behavior assessment for occupational therapy students on a part-time clinical rotation (Level I). The Philadelphia Region Fieldwork Consortium (PRFC) Level I Student Evaluation was developed from an initial survey (n = 75) to …

Download Full Pdf Issue-Jefferson Translations-Vol. 1, No. 1, Summer/Fall 2003

Jefferson Translations

This issue includes a description of Project CARE (Coordinated Approaches Redesigned for Excellence), an article discussing efforts to unlock the human genome, an article describing mobile asthma education efforts in Philadelphia lead by a Jefferson team of specialists, a new Jefferson anticoagulation program, and a model for diabetes education.

Department Of Radiology-Annual Executive Summary Report-July 1, 2002 To June 30, 2003, Vijay M. Rao, M.D.

Department of Radiology Administrative Documents and Reports

94 page Department of Radiology Annual Executive Summary Report, July 1, 2002 to June 30, 2003, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.