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Jefferson Alumni Bulletin – Volume Xlvi, Number 1, December 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 1, December 1996

Rational Drug Design, Page 4

Technology Transfer, Page 7

Clinical Trials, Page 9

World-Class Athletes and Drugs, Page 12

The Makings of the Complete Physician, Page 14

Major Alliance Links Jefferson with Mercy Health, Page 17

“Gene Repair” Corrects Mutation Leading to Disease, Page 19

Genetic Discoveries Lead to New Lung Cancer Tests, Page 20

Alumni Can Participate in JeffHOPE, Page 24

Student AMA Organizes Bone Marrow Drive, Page 25

Glanzmann Thrombasthenia. Cooperation Between Sequence Variants In Cis During Splice Site Selection., Ying Jin, Harry C. Dietz, Robert A. Montgomery, William R. Bell, Iain Mcintosh, Barry Coller, Paul F. Bray

Cardeza Foundation for Hematologic Research

Glanzmann thrombasthenia (GT), an autosomal recessive bleeding disorder, results from abnormalities in the platelet fibrinogen receptor, GP(IIb)-IIIa (integrin alpha(IIb)beta3). A patient with GT was identified as homozygous for a G-->A mutation 6 bp upstream of the GP(IIIa) exon 9 splice donor site. Patient platelet GP(IIIa) transcripts lacked exon 9 despite normal DNA sequence in all of the cis-acting sequences known to regulate splice site selection. In vitro analysis of transcripts generated from mini-gene constructs demonstrated that exon skipping occurred only when the G-->A mutation was cis to a polymorphism 116 bp upstream, providing precedence that two sequence variations …

Nurses Alumni Association Bulletin, Fall 1996, Betty Piersol, Elizabeth K. Prisnock, Marian E. Smith, Margaret Summers, Deborah Fireman, Nicole Herndon

Nursing Alumni Bulletins

1996-1997 Meeting Dates Calendar

1997 Annual Luncheon-Meeting Notice Inside

Officers and Committee Chairs

Bulletin Publication Committee

1996-1997 Meeting Dates Calendar

The President's Message

Treasurer's Report

News About Our Graduates

Letter To Jefferson Nurses

Fiftieth Anniversary

Resume' of Minutes of Alumni Association Meetings

Alumni Office News

Nursing Up-Date 1995-1996

Scholarship Funds At Work

Diploma School of Nursing Alumni Association-Mabel C. Prevost Scholarship Report 1995

Women In Military Service For America Memorial Foundation

Operation Support Freedom - Humanitarian Aid to Kiev

The Best Mousetrap - Computers In Nursing

Christmas, As A Prisoner Of War

Restroom Policy

Happy Birthday

Committee Reports

• Bulletin
• Development …

Moving Occupation Into Treatment: Clinical Interpretation Of "Legitimizing Occupational Therapy's Knowledge"., Janice P. Burke

Department of Occupational Therapy Faculty Papers

No abstract provided.

Jefferson Alumni Bulletin – Volume Xlv, Number 4, September 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 4, September 1996

Commencement Addresses, Page 4

Clinic Presentations, Page 8

Annual Giving, Page 27

Bookstore, Page 54

Department Of Radiology-Annual Report-July 1, 1995 To June 30, 1996, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1995 to June 30, 1996. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 110 pages.

Jefferson Alumni Bulletin – Volume Xlv, Number 3, June 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 3, June 1996

Student Initiative and New Educational Challenges Converge in Community Primary Care, Page 4

Methodist Hospital and Thomas Jefferson University Hospital Merge Services, page 13

Kimmel Foundation Donates $10 Million, Establishing the Kimmel Cancer Center, Page 13

Capizzi Succeeds Caro as Chairman of Medicine, Page 17

DiMarino Appointed Chief of Gastroenterology, Page 17

Book Portrays C. Earl Albrecht ’32 in Alaska, Page 22

Leonard Zon ’83 Continues in Erslev’s Footsteps, Page 25

Is The Use Of Life History And Narrative In Clinical Practice Reimbursable? Is It Occupational Therapy?, Janice P. Burke, Stephen B. Kern

Department of Occupational Therapy Faculty Papers

No abstract provided.

A Polymorphism Of A Platelet Glycoprotein Receptor As An Inherited Risk Factor For Coronary Thrombosis., Ethan J. Weiss, Paul F. Bray, Matthew Tayback, Steven P. Schulman, Thomas S. Kickler, Lewis C. Becker, James L. Weiss, Gary Gerstenblith, Pascal J. Goldschmidt-Clermont

Cardeza Foundation for Hematologic Research

BACKGROUND: Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polymorphism, PlA2, of the gene encoding glycoprotein IIIa in kindreds with a high prevalence of premature myocardial infarction.

METHODS: To investigate the relation between the PlA2 polymorphism and acute coronary syndromes, we conducted a case-control study of 71 case patients with myocardial infarction or unstable angina and 68 inpatient controls without known heart disease. The …

A Tandem Duplication Within The Fibrillin 1 Gene Is Associated With The Mouse Tight Skin Mutation., Linda D. Siracusa, Rodney Mcgrath, Qing Ma, John J. Moskow, Jayanthi Manne, Paul J. Christner, Arthur M. Buchberg, Sergio A. Jimenez

Department of Medicine Faculty Papers

Mice carrying the Tight skin (Tsk) mutation have thickened skin and visceral fibrosis resulting from an accumulation of extracellular matrix molecules. These and other connective tissue abnormalities have made Tskl + mice models for scleroderma, hereditary emphysema, and myocardial hypertrophy. Previously we localized Tsk to mouse chromosome 2 in a region syntenic with human chromosome 15. The microfibrillar glycoprotein gene, fibrillin 1 (FBN1), on human chromosome 15q, provided a candidate for the Tsk mutation. We now demonstrate that the Tsk chromosome harbors a 30- to 40-kb genomic duplication within the Fbn1 gene that results in a larger than normal in-frame …

Jefferson Alumni Bulletin – Volume Xlv, Number 2, March 1996

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLV, Number 2, March 1996 A Conversation with the Alumni Chairman of Family Medicine, Page 4 Stanton N. Smullens ’61: Jefferson Leader, Page 14 Hospital Separates from University as Step in Forming the Jefferson Health System, Page 15 Gene That Helps Cause Gliomas is Identified, Page 16 Altered FHIT Gene is Found in Several Types of Common Cancers, Page 17 Vaccine Treats Rheumatoid Arthritis, Page 18 Blood Test Can Measure Obesity Hormone, Page 19 Gene Therapy for HIV-Infected Patients Will Begin Here, Page 21 Spitzer Authors Neonatology Text, Page 23 Gallo Discovers HIV-Suppresor Factors, page …

Strategies For Prevention Of Varicella Pneumonia: A Cost-Effectiveness Analysis., G A Macones, S Ewing, N S Silverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: The objective of this study was to compare the cost-effectiveness of 3 strategies of serologic enzyme-linked immunosorbent assay (ELISA) testing and post-exposure varicella zoster immune globulin (VZIG) prophylaxis for the prevention of maternal varicella pneumonia during pregnancy in patients with negative or uncertain histories of varicella infection.

METHODS: A decision tree was constructed to compare the following strategies: 1) routine serologic testing for varicella immunity followed by targeted post-exposure VZIG prophylaxis, 2) post-exposure serologic testing followed by targeted VZIG prophylaxis, and 3) untargeted post-exposure VZIG administration. The probabilities for the model were obtained from the medical literature and supplemented …