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Articles 1 - 30 of 433
Full-Text Articles in Medicine and Health Sciences
The Determination Of Meat Species By Pcr-Rflp Method Using Mitochondrial Nd4 Genein Pastırma, A Traditional Dry Cured Meat Product, Serhat Al, Harun Hizlisoy, Nurhan Ertaş Onmaz, Fulden Karadal, Candan Güngör, Yeli̇z Yildirim, Zafer Gönülalan
The Determination Of Meat Species By Pcr-Rflp Method Using Mitochondrial Nd4 Genein Pastırma, A Traditional Dry Cured Meat Product, Serhat Al, Harun Hizlisoy, Nurhan Ertaş Onmaz, Fulden Karadal, Candan Güngör, Yeli̇z Yildirim, Zafer Gönülalan
Turkish Journal of Veterinary & Animal Sciences
Pastırma is a high value, traditional, dry cured, and edible coated meat product. For economic and sociocultural reasons, it is important to know which meat species are used in pastırma. The present study aims to carry out the determination of the meat species in pastırma. A total of 144 pastırma samples were collected from different stores. After genomic DNA isolation, the total DNAs obtained were subjected to polymerase chain reaction (PCR) using specially designed novel primers amplifying the mitochondrial ND4 (MTND4) gene region, specific for cattle (Bos taurus), water buffalo (Bubalus bubalis), horse (Equus caballus), and donkey (Equus asinus) species. …
Pistacia Atlantica Gum Aqueous Extract Modulates Humoral And Cellular Immuneresponses In Balb/C Mice, Hadi Esmeili Gouvarchin Ghaleh, Zaynab Shakarami Gandabeh, Bahman Mansouri Motlagh, Ali Sheikhian
Pistacia Atlantica Gum Aqueous Extract Modulates Humoral And Cellular Immuneresponses In Balb/C Mice, Hadi Esmeili Gouvarchin Ghaleh, Zaynab Shakarami Gandabeh, Bahman Mansouri Motlagh, Ali Sheikhian
Turkish Journal of Veterinary & Animal Sciences
Natural herbal products contain different compounds that can modulate immune and inflammatory diseases. This investigation aimed to examine the influence of Pistacia atlantica aqueous extract on cellular and humoral immunity in mice following the exposure to sheep red blood cells (SRBCs). For this purpose, male BALB/c mice (n = 40) were randomly assigned into 4 equivalent groups. The animals received 1 × 109 SRBCs in complete Freund?s adjuvant (CFA) intraperitoneally 3 times with two-week intervals. Five days after the final injection, blood samples were taken from the animals. Additionally, 1 × 109 SRBCs were also injected into the mice?s left …
The Effects Of Supplemental Niacin And Methionine On Serum Glucose, Betahydroxybutyric Acid, And Non-Esterified Fatty Acid Levels During Late Gestation And Early Postpartum Period In Damascus Dairy Goat, Mustafa Kemal Saribay, Ayşe Merve Köse, Bülent Özsoy, Umair Ahsan, Ece Koldaş Ürer, Serkan İrfan Köse, Gökhan Doğruer
The Effects Of Supplemental Niacin And Methionine On Serum Glucose, Betahydroxybutyric Acid, And Non-Esterified Fatty Acid Levels During Late Gestation And Early Postpartum Period In Damascus Dairy Goat, Mustafa Kemal Saribay, Ayşe Merve Köse, Bülent Özsoy, Umair Ahsan, Ece Koldaş Ürer, Serkan İrfan Köse, Gökhan Doğruer
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to assess the changes in serum glucose, beta-hydroxybutyric acid (ß-HBA), and nonesterified fatty acid (NEFA) levels in Damascus dairy goats fed niacin (Nia) and methionine (Met) during late gestation and early postpartum period. A total of 75 dairy goats at 105th day of gestation were divided into 3 groups as control (no supplementation), Nia (20 g/kg Nia), and Met (2.5 g/kg Met) groups. The dietary treatments continued until parturition. Dairy goats fed dietary Nia had greater serum glucose levels on day 125 of gestation compared to the other dietary treatments (P < 0.05). On day 135 of pregnancy, serum glucose levels were higher in Met group than control group (P < 0.05). Serum ß-HBA levels decreased on days 135 and 145 in dairy goats fed Nia than those in control group. Dietary Nia and Met lowered serum ß-HBA levels on day 10 postpartum compared to control group (P < 0.05). Serum NEFA levels decreased (P < 0.05) on days 135 and 145 in dairy goats fed Nia supplemented ration than those in control group. Serum NEFA levels d 10 postpartum were different among the groups (P < 0.05). In conclusion, dietary Nia and Met supplementation improved serum glucose levels on day 125 of gestation while decreasing ß-HBA and NEFA levels during late gestation and early postpartum period in Damascus dairy goats under the conditions of present study.
Possible Ensiling Of Pumpkin (Cucurbita Pepo) Residues, İsmai̇l Ülger, Mahmut Kali̇ber, Selma Büyükkiliç Beyzi̇, Yusuf Konca
Possible Ensiling Of Pumpkin (Cucurbita Pepo) Residues, İsmai̇l Ülger, Mahmut Kali̇ber, Selma Büyükkiliç Beyzi̇, Yusuf Konca
Turkish Journal of Veterinary & Animal Sciences
The aim of the current study was to determine the feasibility of ensiling pumpkin residues alone and with forage. For this purpose, chemical composition, nutritive values, and in vitro gas production of pumpkin residue silages were investigated. Pumpkin residue (PR), maize fodder (M), sugar beet pulp (SBP), and pomegranate pulp (PP) were ensiled alone, and pumpkin residues were ensiled with maize (PRM), sugar beet pulp (PRSB), and pomegranate pulp (PRP) in 50% (50:50 w:w) of each, as well as with 5% wheat straw (PRS) and alfalfa hay (PRA). After 2 months of storage, chemical compositions and Fleig scores of the …
Comparison Of Different Eggshell Thickness Measurement Methods, Abdulkadi̇r Arslan, Umut Sami̇ Yamak
Comparison Of Different Eggshell Thickness Measurement Methods, Abdulkadi̇r Arslan, Umut Sami̇ Yamak
Turkish Journal of Veterinary & Animal Sciences
This study was conducted to examine how various methods affect the results of eggshell thickness measurements. Direct and indirect measurements were performed on 700 table eggs which were daily collected from the same flock. The shell thickness of the eggs was calculated according to a logarithm which uses egg weight. Eggs with a specific gravity of higher than 0.80 g/cm³ were classified as thick-shelled, whereas the others were categorized as thin-shelled. After determining the shell thickness of the eggs by an ultrasound gauge, all of the eggs were broken, the shells were separated, and the shell thickness of each egg …
The Effect Of Year, Month, Region, And Herd Size On Bulk Tank Somatic Cell And Standardplate Count, And The Determination Of Optimum Herd Size In The Intensive Holsteinfriesian Dairy Farms In The Turkish Republic Of Cyprus, Hati̇ce Di̇lek Arsoy
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to determine the effects of mount, year, region, and herd size on the bulk tank somatic cell count (SCC) and standard plate count (SPC) and total milk production of Holstein Friesian cows and to decide for optimum herd size in Northern Cyprus. The total number of cattle was 64,450 heads and the number of enterprises was 168 in 2016. The milk samples were collected once or twice a month from each herd. SCC and SPC were determined with the Fluoro-opto-electronic counter method. Herd sizes were described from small to extra-large enterprises for Northern Cyprus …
Assessment Of The Molluscicidal Activity Of Wormwood (Artemisia Dubia, Wallich) Leaves Ethanolic Extract On Oncomelania Hupensis Quadrasi, Möllendorff, Claudine C. Terciño, Carl Leonard M. Pradera, Melvin A. Bagot
Assessment Of The Molluscicidal Activity Of Wormwood (Artemisia Dubia, Wallich) Leaves Ethanolic Extract On Oncomelania Hupensis Quadrasi, Möllendorff, Claudine C. Terciño, Carl Leonard M. Pradera, Melvin A. Bagot
Turkish Journal of Veterinary & Animal Sciences
This study assessed the in vitro molluscicidal activity of Artemisia dubia (wormwood) leaf ethanolic extract against adult and juvenile Oncomelania hupensis quadrasi and profiled its qualitative phytochemical content. The plants and snails were collected locally. There were 8 concentrations used for adult and juvenile snails: distilled water and 1% ethanol as negative controls; niclosamide (2 mg/L) as a positive control; and different concentrations of wormwood ethanolic extracts for adult snails including 3.98% (T1), 4.46% (T2), 5% (T3), 5.61% (T4), and 6.30% (T5) and for juvenile snails including 7.94% (T1), 8.91% (T2), 10% (T3), 11.22% (T4), and 12.59% (T5). Each treatment …
The Investigation Of The Possible Antigenotoxic In Vivo Effects Of Pomegranate (Punica Granatum L.) Peel Extract On Mitomycin-C Genotoxicity, Erhan Uluman, Pinar Aksu Kiliçle
The Investigation Of The Possible Antigenotoxic In Vivo Effects Of Pomegranate (Punica Granatum L.) Peel Extract On Mitomycin-C Genotoxicity, Erhan Uluman, Pinar Aksu Kiliçle
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the possible antigenotoxic effects of the extract of pomegranate (Punica granatum L.) peel, which has high antioxidant activity against the genotoxic effects that mitomycin-C creates in the bone marrow cells of mice by a chromosomal aberration, mitotic activity, and micronucleus test system. There were six groups including a negative control group, positive control group (2 mg/kg mitomycin-C (MMC)), 150 mg/kg P. granatum L. (PG) peel extract, 300 mg/kg PG peel extract, 150 mg/ kg PG + MMC, and 300 mg/kg PG + MMC. The extract of pomegranate peel was given to mice …
Determination Of Fat Preferences Of Adult Dogs, Fatma İnal, Mustafa Selçuk Alataş, Oğuzhan Kahraman, Şeref İnal, Mustafa Uludağ
Determination Of Fat Preferences Of Adult Dogs, Fatma İnal, Mustafa Selçuk Alataş, Oğuzhan Kahraman, Şeref İnal, Mustafa Uludağ
Turkish Journal of Veterinary & Animal Sciences
This study was carried out to determine the preferences of dogs for some commonly used fat sources in dog food. Three different types of food were produced using 5% additional sunflower oil, poultry fat, or beef tallow. The food was extruded using a twin-screw extruder at approximately 25% moisture and temperatures in the range of 90 °C to 135 °C. The extrudates were dried for 30-45 min at temperatures of up to 148 °C in a belt dryer. Next, the heated fats were sprayed onto the extrudates. The foods were cooled, sampled, and packaged. A total of 30 neutered adult …
The Anti Proliferative Effects Of Rosemary Oil On Keratinocyte Cell Line, Hacat, Muhammet Kuddusi̇ Erhan
The Anti Proliferative Effects Of Rosemary Oil On Keratinocyte Cell Line, Hacat, Muhammet Kuddusi̇ Erhan
Turkish Journal of Veterinary & Animal Sciences
This study aims to investigate the action of rosemary oil on the immortalized keratinocyte cell line. Samples of Rosmarinus officinalis that were growing uncultivated in central Turkey were harvested during flowering in May 2016. The rosemary oil was obtained by the hydrodistillation of the dried ground material in a Clevenger-like apparatus. Human cells from the immortalized nontumorigenic keratinocyte cell line were seeded at a concentration of 5000 cells/well on 96 well plates. Cell viability was measured at the 24, 48, and 72 h. Five different doses of 1.25% to 20% Rosmarinus officinalis oil, 20% DMSO (for toxic examination), and 1 …
Prevalence Of Gastrointestinal Parasitic Infections In Cattle And Sheep In Two Regions Ofromania, Catalin Bogdan Sirbu, Kalman Imre, Gheorghe Darabus, Tiana Suici, Bogdan Mates, Sorin Morariu
Prevalence Of Gastrointestinal Parasitic Infections In Cattle And Sheep In Two Regions Ofromania, Catalin Bogdan Sirbu, Kalman Imre, Gheorghe Darabus, Tiana Suici, Bogdan Mates, Sorin Morariu
Turkish Journal of Veterinary & Animal Sciences
Amongst ruminant livestock diseases, the gastrointestinal (GIT) helminths and protozoan parasite infections result in a significant socio-economic concern worldwide. During the period between October 2017 and November 2018, a total of 788 fresh fecal specimens from cattle (n = 303) and sheep (n = 485) were screened for the presence of gastrointestinal helminths and protozoan parasites in two historical regions (Crisana and Banat) of western Romania. Laboratory processing of fecal samples with the simple salt flotation (Willis) and sedimentation techniques, followed by microscopic analysis revealed that 86.1% of cattle and 92.6% of sheep were found to be positive for at …
The Effect Of Paddy Straw And Concentrate Containing Green Tea Dust On Performance Andnutrient Digestibility In Feedlot Lambs, Diky Ramdani, Dwi Cipto Budinuryanto, Novi Mayasari
The Effect Of Paddy Straw And Concentrate Containing Green Tea Dust On Performance Andnutrient Digestibility In Feedlot Lambs, Diky Ramdani, Dwi Cipto Budinuryanto, Novi Mayasari
Turkish Journal of Veterinary & Animal Sciences
The utilization of low-input paddy straw hay (PSH) for fattening lambs should be incorporated with a high-quality concentrate (HQC) in which green tea dust (GTD) rich in tannins can be added as a natural feed additive. Completely randomized design was used to compare 5 doses of GTD inclusions (dry matter, DM basis) at 0% (GTD-0), 0.5% (GTD-0.5), 1% (GTD-1), 1.5% (GTD-1.5), and 2% (GTD-2) in an HQC as the main diet of PSH-fed fattening lambs on average daily gain (ADG, g/head/day), dry matter intake (DMI, g/head/day), and nutrient digestibility (%) using 6 replicates. The results showed that GTD-1.5 resulted in …
Effects Of Some Disinfectants On Toxocara Spp.Eggs Viability Of Dogs And Cats, Iasmina Luca, Ion Oprescu, Sorin Morariu, Narcisa Mederle, Marius Stelian Ilie, Gheorghe Darabuş
Effects Of Some Disinfectants On Toxocara Spp.Eggs Viability Of Dogs And Cats, Iasmina Luca, Ion Oprescu, Sorin Morariu, Narcisa Mederle, Marius Stelian Ilie, Gheorghe Darabuş
Turkish Journal of Veterinary & Animal Sciences
The main cause of larva migrans syndrome (LMS) in humans is represented by Toxocara spp. found in dogs and cats. In the present study, the effects of three disinfectants based on quaternary ammonium compounds (Kohrsolin® FF, Trioton$^{®}$ rapid AF and Terralin$^{®}$ protect) and one based on propanol and ethanol (Bacillol$^{®}$), against Toxocaracanis and Toxocaracati eggs, were tested. These disinfectants have a strong antimicrobial and virucidal action. Two different exposure times and different concentrations for solutions were used. All four disinfectants presented high percentages of destructive effects against Toxocaracanis eggs, after 21 days of exposure. The vast majority of eggs with …
Comparative Morphological Analysis Of Diploid And Triploid Oysters, Crassostrea Gigas,Farmed In The Black Sea, Oksana Yurievna Vialova
Comparative Morphological Analysis Of Diploid And Triploid Oysters, Crassostrea Gigas,Farmed In The Black Sea, Oksana Yurievna Vialova
Turkish Journal of Veterinary & Animal Sciences
Triploid organisms, in particular oysters, are widely used in marine aquaculture. However, the advantage of triploid oysters compared to diploids has not been proven in all cases. Comparative morphological analysis of Pacific oysters Crassostrea gigas of different ploidy levels allows evaluating the benefits of raising triploids in the Black Sea. First, the morphological characteristics of diploid and triploid Pacific oysters C. gigas farmed in the Black Sea were studied. Allometric ratios of weight (W, g) and shell height (H, mm) of oysters were obtained, which are described by the equations W$_{2n}$ = 4 × 10$^{-4}$ × H$_{2n}$ $^{2.56}$, R2 = …
An Atypical Localization Of Bacillus Anthracis In A Cow's Milk And Udder, Mi̇tat Şahi̇n, Fati̇h Büyük, Özgür Çelebi̇, Mustafa Reha Coşkun
An Atypical Localization Of Bacillus Anthracis In A Cow's Milk And Udder, Mi̇tat Şahi̇n, Fati̇h Büyük, Özgür Çelebi̇, Mustafa Reha Coşkun
Turkish Journal of Veterinary & Animal Sciences
A 6-year-old Simental-Swiss Brown cross-bred cow, which aborted in the first trimester of the gestation and involuntarily presented anthrax bacilli around the udder, was subjected to this study. The cow was vaccinated with an attenuated anthrax vaccine (Bacillus anthracis 34 F2) 6 months ago and had normal physical examination findings. Samples taken 10 days after the abortion were representative of all possible spaces that could carry the bacteria such as milk, blood, environment, and swabs from rectum, udder and tits of an infected cow. Microbiological examination was carried out by staining the smears with Azure and in vitro culture of …
Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen
Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen
Turkish Journal of Medical Sciences
Background/aim: Filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) are associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FLG gene and determine the association between FLG loss-of-function (LOF) mutations and FA and/or AD in Turkish children. Materials and methods: Four FLG loss-of-function (LOF) mutations known to be common in European populations were analyzed in 128 healthy children, 405 food-allergic children with or without atopic dermatitis, …
Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe
Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe
Turkish Journal of Medical Sciences
Background/aim: This study aims to serve as a unique consolidated source in Turkey's vaccination history and as an example for other countries by objectively revealing the change in mortality and morbidity rates in Turkey following the beginning of vaccination without asserting any claim on the benefits or risks of vaccines. This unbiased research will also help health professionals identify the challenges more easily when they face with the people who hesitate to vaccinate their children. Materials and methods: Descriptive research design is adopted in this study. The coverages of vaccinations, mortality, and morbidity rates were identified through a retrospective analysis …
Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu
Peripheral Axonal Excitability In Hemiplegia Related To Subacute Stroke, Zeynep Turan, Murat Zi̇nnuroğlu
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate peripheral nerve excitability in patients with subacute stroke. Materials and methods: The study was performed in 29 stroke patients within the subacute period and 29 healthy controls using QTRAC software and TRONDNF protocol. The threshold electrotonus, recovery cycle, stimulus-response, strength-duration, and current-threshold relationships were recorded. Results: The membrane was more hyperpolarized, and excitability was decreased in the hemiplegic side. The impairment of inward rectifying channel function, degree of hyperpolarization, and decrease of excitability were directly related to the Brunnstrom stages, which were more pronounced in lower stages. Conclusion: The lower motor neurons were affected …
Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu
Emerging And Reemerging Respiratory Viral Infections Up To Covid-19, İlhami̇ Çeli̇k, Esma Saatçi̇, Ayşegül Füsun Eyüboğlu
Turkish Journal of Medical Sciences
Infectious diseases remain as the significant causes of human and animal morbidity and mortality, leading to extensive outbreaks and epidemics. Acute respiratory viral diseases claim over 4 million deaths and cause millions of hospitalizations in developing countries every year. Emerging viruses, especially the RNA viruses, are more pathogenic since most people have no herd immunity. The RNA viruses can adapt to the rapidly changing global and local environment due to the high error rate of their polymerases that replicate their genomes. Currently, coronavirus disease 2019 (COVID-19) is determined as an infectious disease caused by severe acute respiratory syndrome coronavirus 2 …
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Covid-19, Immune System Response, Hyperinflammation And Repurposingantirheumatic Drugs, Abdurrahman Tufan, Aslihan Avanoğlu Güler, Marco Matucci-Cerinic
Turkish Journal of Medical Sciences
In the Wuhan Province of China, in December 2019, the novel coronavirus 2019 (COVID-19) has caused a severe involvement of the lower respiratory tract leading to an acute respiratory syndrome. Subsequently, coronavirus 2 (SARS-CoV-2) provoked a pandemic which is considered a life-threatening disease. The SARS-CoV-2, a family member of betacoronaviruses, possesses singlestranded positive-sense RNA with typical structural proteins, involving the envelope, membrane, nucleocapsid and spike proteins that are responsible for the viral infectivity, and nonstructural proteins. The effectual host immune response including innate and adaptive immunity against SARS-Cov-2 seems crucial to control and resolve the viral infection. However, the severity …
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Covid-19: Pathogenesis, Genetic Polymorphism, Clinical Features And Laboratory Findings, Recep Öztürk
Turkish Journal of Medical Sciences
COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. The pathogenesis of COVID-19 starts with the bonding of the virus to ACE2 receptors expressed in many tissues, and the triggered excessive immune response plays a critical role in the course of the disease. The cytokine storm that occurs upon excessive production of pro-inflammatory cytokines is considered responsible for the severe progression of the disease and the organ damage. However, the accurate pathophysiological mechanism of the disease, which progresses …
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Tuberous Sclerosis: A Review Of The Past, Present, And Future, Sanem Pinar Uysal, Mustafa Şahi̇n
Turkish Journal of Medical Sciences
Tuberous sclerosis complex (TSC) is an autosomal dominant, multisystem disorder that is characterized by cellular and tissue dysplasia in several organs. With the advent of genetic and molecular techniques, mutations in the TSC1 or TSC2 genes were discovered to be responsible for mTOR overactivation, which is the underlying mechanism of pathogenesis. TSC is a highly heterogenous clinical entity with variable presentations and severity of disease. The brain, heart, skin, eyes, kidneys, and lungs are commonly involved in this syndrome, with neurologic symptoms comprising a significant source of morbidity and mortality. In 2012, the diagnostic criteria for TSC were revised by …
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Bmp And Tgfß Use And Release In Bone Regeneration, Zeynep Bal, Junichi Kushioka, Joe Kodama, Takashi Kaito, Hideki Yoshikawa, Petek Korkusuz, Feza Korkusuz
Turkish Journal of Medical Sciences
A fracture that does not unite in nine months is defined as nonunion. Nonunion is common in fragmented fractures and large bone defects where vascularization is impaired. The distal third of the tibia, the scaphoid bone or the talus fractures are furthermore prone to nonunion. Open fractures and spinal fusion cases also need special monitoring for healing. Bone tissue regeneration can be attained by autografts, allografts, xenografts and synthetic materials, however their limited availability and the increased surgical time as well as the donor site morbidity of autograft use, and lower probability of success, increased costs and disease transmission and …
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Mean Platelet Volume And Response To The First Line Therapy In Newly Diagnosed Adultimmune Thrombocytopenia Patients: A Retrospective Study, Erman Akkuş, Çi̇ğdem Fi̇dan, Gülşah Demi̇rci̇, Ali̇ Aytuğ Kuştaş, Meltem Yüksel
Turkish Journal of Medical Sciences
Background/aim: Immune thrombocytopenia (ITP) is treated by corticosteroids and/or intravenous immune globulin as the first line treatment when necessary. Mean platelet volume (MPV) is a marker of platelet production and function. In this study, we aimed to search the relationship between the MPV and the treatment response in ITP patients and it was hypothesized that MPV can be used as a predictor of the response. Materials and methods: The 70 newly diagnosed adult primary ITP patients and 70 of healthy people were included. MPV between ITP and healthy population, MPV in the diagnosis and after the treatment between the responders …
The Needle Electromyography Findings In The Neurophysiological Classification Of Ulnar Neuropathy At The Elbow, Hali̇t Fi̇danci, İlker Öztürk, Ahmet Candan Köylüoğlu, Mehmet Yildiz, Şencan Buturak, Zülfi̇kar Arlier
The Needle Electromyography Findings In The Neurophysiological Classification Of Ulnar Neuropathy At The Elbow, Hali̇t Fi̇danci, İlker Öztürk, Ahmet Candan Köylüoğlu, Mehmet Yildiz, Şencan Buturak, Zülfi̇kar Arlier
Turkish Journal of Medical Sciences
Background/aim: Although ulnar neuropathy at the elbow (UNE) is the second most common entrapment mononeuropathy, there are few reports on its neurophysiological classification. In this study, we tried to find out the role of needle electromyography (EMG) in the neurophysiological classification of UNE. Materials and methods: UNE patients who met the clinical and neurophysiological diagnostic criteria and healthy individuals were included in this study. Reference values of nerve conduction studies were obtained from healthy individuals. Needle EMG was performed to all UNE patients. According to the neurophysiological classification proposed by Padua, UNE patients were classified as mild, moderate, and severe. …
The Effect Of Iatrogenic Subclinical Hyperthyroidism On Anxiety, Depression And Quality Of Life In Differentiated Thyroid Carcinoma, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Yusuf Bozkuş, Şeri̇fe Mehli̇ka Işildak, Cüneyd Anil, Sevde Nur Firat, Canan Demi̇r, Asli Nar, Nesli̇han Başçil Tütüncü
The Effect Of Iatrogenic Subclinical Hyperthyroidism On Anxiety, Depression And Quality Of Life In Differentiated Thyroid Carcinoma, Nazli Gülsoy Kirnap, Özlem Turhan İyi̇di̇r, Yusuf Bozkuş, Şeri̇fe Mehli̇ka Işildak, Cüneyd Anil, Sevde Nur Firat, Canan Demi̇r, Asli Nar, Nesli̇han Başçil Tütüncü
Turkish Journal of Medical Sciences
Background/aim: Overt thyroidism is known to cause neuropsychiatric disorders but studies on subclinical hyperthyroidism (SCH) are limited. Subclinical hyperthyroidism induction by administering L-Thyroxine (LT4) is the standard treatment method in differentiated thyroid carcinoma (DTC) follow-up. Our aim was to investigate whether anxiety, depression and quality of life are affected in DTC patients followed-up with exogenous SCH. Materials and methods: The patients were divided into exogenous SCH by LT4-DTC (n = 127), euthyroid-DTC (n = 66) and exogenous euthyroid-benign thyroid noduüle (BTN) who underwent thyroidectomy for benign thyroid pathology (n = 85) groups. Results: The rate of moderate/severe anxiety was significantly …
Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇
Factors Associated With Severe Lung Disease In An Adult Population With Cystic Fibrosis: A Single-Center Experience, Berri̇n Er, Ebru Çelebi̇oğlu, Ebru Yalçin, Deni̇z Doğru, Özlem Erden Aki̇, Ömrüm Uzun, Murat Akova, Uğur Özçeli̇k, Nural Ki̇per, Sali̇h Emri̇
Turkish Journal of Medical Sciences
Background/Aim: The patients with cystic fibrosis (CF) are living longer compared to the past, but respiratory failure is still the most common cause of mortality. The aim of this study is to investigate factors associated with severe lung disease in a cohort of adult patients with CF. Materials and methods: Demographic data, clinical and laboratory findings of the patients aged 18 years and more were collected and the patients were grouped according to forced expiratory volume in 1 s (FEV1) as severe group:
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Psychometric Evaluation Of The Persian Version Of The Doloplus-2 (P-Doloplus-2) Scale In Elderly With Dementia, Mohammad Zare, Zahra Tagharrobi, Khadijeh Sharifi, Zahra Sooki, Javad Abolhasani
Turkish Journal of Medical Sciences
Background/aim: A scale for behavioural pain assessment is useful for the detection and determination of pain in the elderly with dementia. This study aimed to translate and evaluate the psychometric properties of Doloplus-2 in the elderly with dementia in Iran. Materials and methods: In this methodological study, after translation and evaluating the face and content validity of Doloplus-2, 100 elderly people were selected by the convenience sampling method in Kashan, 2018-2019. Exploratory factor analysis, convergent validity, and known-groups comparison were applied to determine construct validity. Reliability was also assessed through internal consistency, equivalence, and stability methods were used. The ceiling …
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Spectrum Of Germline Cancer Susceptibility Gene Mutations In Turkish Colorectal Cancer Patients: A Single Center Study, Haktan Bağiş Erdem, Taha Bahsi̇
Turkish Journal of Medical Sciences
Background/aim: Quarter of colorectal cancer patients have a family history and 6% of these comprise hereditary cancer syndromes. For developing national health strategies for genetic screening, it is crucial to determine the spectrum of damaging alterations in causative genes and to describe frequent founder mutations. Materials and methods: One hundred and thirty six unrelated colorectal cancer cases were investigated. Qiagen large hereditary cancer panel and Hereditary Cancer Solution v1.1 panel were used for sequencing. The sequencing process was performed on the Illumina MiSeq system. The data analyses were performed on QIAGEN Clinical Insight (QCITM) Analyze software and Sophia DDM software. …
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Roles Of Glycoprotein Glycosylation In The Pathogenesis Of An Endemic Osteoarthritis, Kashin-Beck Disease, And Effectiveness Evaluation Of Sodium Hyaluronate Treatment, Sen Wang, Zongqiang Gao, Huan Liu, Peilin Meng, Cuiyan Wu, Mikko Lammi, Xiong Guo
Turkish Journal of Medical Sciences
Background/aim: We aimed to explore the roles of glycoprotein glycosylation in the pathogenesis of Kashin-Beck disease (KBD), and evaluated the effectiveness of sodium hyaluronate treatment. Materials and methods: Blood and saliva were collected from KBD patients before and after the injection of sodium hyaluronate. Normal healthy subjects were included as controls. Saliva and serum lectin microarrays and saliva and serum microarray verifications were used to screen and confirm the differences in lectin levels among the three groups. Results: In saliva lectin microarray, bindings to Sophora japonica agglutinin (SJA), Griffonia (Bandeiraea) simplicifolia lectin I (GSL-I), Euonymus europaeus lectin (EEL), Maackia amurensis …