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Suture Cruroplasty Versus Prosthetic Hiatal Herniorrhaphy For Large Hiatal Hernia: A Meta-Analys Is And Syste Matic Review Of Randomiz Ed Controlled Trials, Muhammed Ashraf Memon, Breda Memon, Rossita Mohamad Yunus, Shahjahan Khan

Muhammed Ashraf Memon

Objective:

The aim was to conduct a meta-analysis of randomized controlled trials (RCTs) comparing 2 methods of hiatal closure for large hiatal hernia and to evaluate their strengths and flaws.

Methods:

Prospective RCTs comparing suture cruroplasty versus prosthetic hiatal herniorrhaphy for large hiatal hernia were selected by searching PubMed, Medline, Embase, Science Citation Index, Current Contents, and the Cochrane Central Register of Controlled Trials published between January 1991 and October 2014. The outcome variables analyzed included operating time, complications, recurrence of hiatal hernia or wrap migration, and reoperation. These outcomes were unanimously decided to be important because they influence the …

Functional And Radioligand Binding Characterization Of The A1l-Adrenoceptor Subtype Of The Human Vas Deferens, B Davis, M Wiener, Christopher R. Chapple, Donna Sellers, R. Chess-Williams

Russ Chess-Williams

Summary: Alpha1-adrenoceptor antagonists can cause ejaculatory dysfunction as an adverse effect. Contractions of the human vas deferens are mediated via α1A-adrenoceptors, and this study investigated whether the low affinity state of this receptor (α1L-adrenoceptor) is involved in mediating contractions of this tissue. The potency of agonists and the affinity of receptor subtype selective antagonists were determined in functional experiments and in [3H]tamsulosin binding experiments to identify the α1-adrenoceptor subtype population present in the human vas deferens. The α1A-adrenoceptor selective agonist A61603 was a full agonist and was 250-fold more potent than noradrenaline. Prazosin antagonized contractile responses to phenylephrine with a …