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Full-Text Articles in Medicine and Health Sciences
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Alison L Jones
Oral isosorbide-5-mononitrate (Is-5-Mn) was given in doses of 10 and 40 mg acutely and chronically (twice daily for four weeks), allowing a nitrate free interval to 25 patients with cirrhosis. Both 10 mg and 40 mg Is-S-Mn reduced the hepatic venous pressure gradient acutely and chronically, without evidence of tolerance. This was achieved by a reduction in the wedged hepatic venous pressure. The effect on mean azygos blood flow was variable with no significant mean change seen acutely or after chronic use with either dose. The variability was dependent not on the dose used but on the initial azygos flow; …
How Feasible Is It To Conform To The European Guidelines On Administration Of Activated Charcoal Within One Hour Of An Overdose?, A Karim, S Ivatts, Paul Dargan, Alison Jones
How Feasible Is It To Conform To The European Guidelines On Administration Of Activated Charcoal Within One Hour Of An Overdose?, A Karim, S Ivatts, Paul Dargan, Alison Jones
Alison L Jones
Objectives—The European and American position statement on the use of activated charcoal recommends its administration within an hour of ingestion of a charcoal binding poison. But in reality, this time limit is difficult to follow for the majority of poisoned patients. This study aimed to examine the treatment of acutely poisoned patients with activated charcoal in an accident and emergency (A&E) department. Methods—63 patients who had taken potentially serious overdoses and required hospital admission from a London teaching hospital A&E department were identified over a six month period. The patients’ case notes were analysed for age, sex, substances taken, and …
Doctors' Knowledge Of The Appropriate Use And Route Of Administration Of Antidotes In The Management Of Recreational Drug Toxicity, S Lidder, Hanna Ovaska, J.R.H Archer, S Greene, Alison Jones, Paul Dargan, David Wood
Doctors' Knowledge Of The Appropriate Use And Route Of Administration Of Antidotes In The Management Of Recreational Drug Toxicity, S Lidder, Hanna Ovaska, J.R.H Archer, S Greene, Alison Jones, Paul Dargan, David Wood
Alison L Jones
Background: Specific antidotes (eg, naloxone, flumazenil, cyproheptadine and benzodiazepines) are available for the management of certain recreational drug-induced toxicities. Some controversies surround the use of some of these antidotes, especially flumazenil in benzodiazepine toxicity. There are no previously published data on doctors’ knowledge of the use of these specific antidotes. Methods: A questionnaire survey was designed to determine internal/emergency medicine doctors’ knowledge of the appropriate use of antidotes in the management of clinical scenarios of acutely poisoned patients. For nine simulated clinical scenarios of acute toxicity from recreational drugs (benzodiazepines, cocaine, N-methyl-L-(3, 4-methylene-dioxyphenyl)-2-aminopropane (MDMA)-induced serotonin toxicity and opioids), they were …
A Case Of Hypomagnesaemia Due To Malabsorption, Unresponsive To Oral Administration Of Magnesium Glycerophosphate, But Responsive To Oral Magnesium Oxide Supplementation, J Ross, Paul Dargan, Alison Jones, A Kostrzewski
A Case Of Hypomagnesaemia Due To Malabsorption, Unresponsive To Oral Administration Of Magnesium Glycerophosphate, But Responsive To Oral Magnesium Oxide Supplementation, J Ross, Paul Dargan, Alison Jones, A Kostrzewski
Alison L Jones
Introduction—Oral and intravenous replacement of minerals such as magnesium and calcium are usually straightforward in clinical practice, the choice generally being governed by the preparation most readily available. There are very few data comparing efficacy and absorption profiles of different magnesium salts. This case report highlights the importance of considering alternative preparations of oral magnesium salts in patients who appear unresponsive to one preparation, rather than moving on to chronic intravenous therapy via a Hickman line. In the case of patients with small bowel shortening, the use of magnesium oxide should be considered.