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Full-Text Articles in Medicine and Health Sciences
Direct Inhibition Of Cdk9 Blocks Hiv-1 Replication Without Preventing T Cell Activation In Primary Human Peripheral Blood Lymphocytes, Dominic Salerno, Muneer G Hasham, Renée Marshall Demarest, Judit Garriga, Alexander Y Tsygankov, Xavier Graña
Direct Inhibition Of Cdk9 Blocks Hiv-1 Replication Without Preventing T Cell Activation In Primary Human Peripheral Blood Lymphocytes, Dominic Salerno, Muneer G Hasham, Renée Marshall Demarest, Judit Garriga, Alexander Y Tsygankov, Xavier Graña
Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship
HIV-1 transcription is essential for the virus replication cycle. HIV-1 Tat is a viral transactivator that strongly stimulates the processivity of RNA polymerase II (RNAPII) via recruitment of the cyclin T1/CDK9 positive transcription elongation factor, which phosphorylates the C-terminal domain (CTD) of RNAPII. Consistently, HIV-1 replication in transformed cells is very sensitive to direct CDK9 inhibition. Thus, CDK9 could be a potential target for anti-HIV-1 therapy. A clearer understanding of the requirements for CDK9 activity in primary human T cells is needed to assess whether the CDK9-dependent step in HIV-1 transcription can be targeted clinically. We have investigated the effects …
Articulations 2007, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj
Articulations 2007, Som School Of Osteopathic Medicine, Umdnj University Of Medicine And Dentistry Of Nj
Yearbooks
University of Medicine and Dentistry of New Jersey (UMDNJ) School of Osteopathic Medicine yearbook for the class of 2007. 104 pages.
Contents: Osteopathic Oath p.1, UMDNJ-SOM Campus p. 2, University Affiliated Medical Centers p. 3, Dean's Message p. 4, Administration p. 5, Faculty p. 6, Presenting the Class of 2007 p. 16, Candids p. 18, Graduates p. 34, Next to the Last Blast p. 80, Convocation and Commencement p. 82, Editor's Message p. 89, In Remembrance p. 90.