Medicine and Health Sciences Commons^™

Chromosomal Localization Of The Islet Neogenesis Associated Protein (Ingap) Gene In Syrian Hamster By Tyramide Signal Amplification-Fluorescence In Situ Hybridization (Tsa-Fish), Sallie A. Smith

Biological Sciences Theses & Dissertations

Diabetes mellitus is a group of conditions characterized by hyperglycemia due to an inability to produce or properly utilize insulin. The majority of cases fall into two categories, Type I and Type 2. Type I results from the autoimmune destruction of pancreatic β-cells of the islets. The beta cells are the exclusive source of insulin and the patient becomes entirely dependent on exogenous insulin to survive. Patients with Type 2 are distinguished by insulin resistance, a condition that develops due to the inability of the body to effectively use the insulin being produced. The β-cells gradually lose their ability to …

Natural And Synthetic Viniferins Associated With The Grapevine Disease Young Vine Decline, David Michael Mcginnis

Chemistry & Biochemistry Theses & Dissertations

Grapevine disease has been thc subject of intense research amongst viticulturists over the last few decades, especially during the 1990's. There has been discoveries that suggest grapevine disease is commonly caused by fungal pathogens. One of the most common fungi that the vine may become infected by is known as Botrytis cinerea. B. cinerea is capable of attacking the grapevine which in turn will lead to bunch rot in the grape clusters. This disease has been researched in great detail during the past several years and is one of only few microorganisms that have actually been identified. Phaeoacremrmium chnlmydospnrum …

Using Social Cognitive Theory To Model Health Behaviors Among Chinese Children, Yan Zhang

Health Services Research Dissertations

This study examined the usefulness of Social Cognitive Theory (SCT) to model fast-food intake, fruit/vegetable consumption, and regular physical activity among a group of Chinese-American children in a Southeastern Virginia urban area.

An observational cross-sectional survey research design and snowball sampling were used. The survey employed items from the Health Behavior Questionnaire, the Youth Risk Behavior Survey, and a 24-hour Diet Recall Form. Eighty-four children completed the self-administered survey; 54 of these were enrolled in a Chinese Weekend School. The mean age of the children was 10.5 years (range 6-18) and 43% were girls. Logistic regression models were used to …

Use Of Miswak Versus Toothbrushes: Oral Health And Behaviors Of Jordanian Adults, Reem Saleem Tubaishat

Dental Hygiene Theses & Dissertations

The purpose of this study was to determine the perceived relationship among miswak, the toothbrush, and toothbrush-plus-miswak usage on oral health beliefs and behaviors of Jordanians. To examine these relationships, a self-designed questionnaire was distributed to a convenience sample of 150 adult subjects (ages 18-60 years) seeking dental care at the health center, and two private dental clinics in Irbid, Jordan. Via the Oral Health Beliefs and Behaviors of Jordanian People Questionnaire, participants were asked to select one and sometimes more than one response regarding their perceived oral health status and oral care behaviors. Content validity of the questionnaire …

What Is Positive Disclosure And To Whom Do We Disclose? The Role Of Topics, Gender And Type Of Relationship In Positive Self-Disclosure, Elizabeth Landers Ford

Psychology Theses & Dissertations

This study examined what topics (including experiences, feelings, and thoughts) people define as positive self-disclosure. The study also looked at reasons people generate for self-disclosing versus not disclosing something positive. Male and female students spontaneously described a past experience or feeling they perceive to be personal and positive. They then indicated whether or not they disclosed about these experiences or feelings to their father, mother, same-sex friend, and a past or present significant other/spouse. These descriptions were coded into one of eight categories: Religion, Family Development, Friendship, Sex, Romance, Self-Confidence, Achievement, and Helping Behavior, plus a Miscellaneous category. There were …

The Great Pestilence: Yellow Fever In Portsmouth, Virginia, 1855, Burden Susan Lundgren

Health Services Research Dissertations

In 1855, the town of Portsmouth, Virginia was devastated by an epidemic of yellow fever. Most citizens fled. Of those who remained, most became infected and a thousand died. The municipal government collapsed. In their place, a small organization known as the Portsmouth Relief Association assumed responsibility for ensuring the survival of the town. This organization managed the care of the sick, the burial of the dead, and the care of orphans. It was the sole agent receiving and allocating the funds and resources that poured into the community. Scarce food, drugs and other supplies were available only through the …

The Immediate Effect Of Cryotherapy At The Ankle Joint On Postural Control, Bradley W. Sage

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to determine the immediate effect of cryotherapy at the ankle joint on measures of static and dynamic postural control. Scores for the chronically unstable ankle were analyzed during a static and dynamic stability test through the use of video analysis. The static test consisted of each subject performing a single leg stance on a multi-axial progressive balance board for one minute. The dynamic test consisted of each subject performing an agility hop test, in which they "hopped" to each of six squares marked on the floor in sequential order. The dependent measure for each …

The Antitumor Agent, Arglabin-Dma, Preferentially Induces Apoptosis In Human Colon Tumor Cells, Sung Wook Kwon

Theses and Dissertations in Biomedical Sciences

Arglabin-DMA, an analog of farnesyl pyrophosphate (FPP), reportedly inhibits farnesyltransferase (FTase) directly by competitively blocking the binding of Ras protein and its posttranslational modification, as suggested in previous studies. But, the mechanisms by which Arglabin-DMA inhibits tumor growth in vivo and in vitro are still relatively poorly characterized. To determine the mechanism by which this drug inhibits tumor growth, the effects of Arglabin-DMA in two human colon tumor cell lines (mutant K-ras HCT 116 and wild-type ras HT-29) were explored on cell proliferation, apoptosis, and cell cycle kinetics in vitro. In cell viability studies, we showed that Arglabin-DMA …

Mechanisms Of Cell Death Initiated In Herpes Simplex Virus Thymidine Kinase Expressing Colon Tumor Cells Treated With Ganciclovir And Ucn-01, Christina Elizabeth Ahn

Theses and Dissertations in Biomedical Sciences

Metastatic colon carcinoma is the second leading cause of death from malignancy in the United States, and development of more effective treatments is essential. Heterologous expression of Herpes Simplex Virus Thymidine Kinase (HSVtk) in combination with the prodrug, ganciclovir (GCV), has shown great promise for the genetic therapy of many cancers, but most patients have had only a partial or minimal response to the therapy. After screening a panel of two drug combinations, our laboratory has shown that the combination of GCV and the protein kinase inhibitor UCN-01 (7-hydroxystaurosporine) enhances tumor cell death more effectively than either drug alone. However …

Cultural Competence And Curricula In Physical Therapist Professional Education, Beth Ernst Jamali

Theses and Dissertations in Urban Services - Urban Education

The purpose of this research was to examine the methods and degree to which content related to cultural competence is incorporated into current entry-level physical therapist education. Face-to-face interviews were performed with 10 program directors from various physical therapist education programs across the country to obtain in-depth information regarding cultural competence in the physical therapy curricula. A questionnaire was sent to all of the 193 accredited physical therapist education programs in the United States as a second means to collect information regarding the methods and extent to which cultural competence is included in the physical therapy curricula. Data were collected …

Predictors Of Student Success In An Entry-Level Baccalaureate Dental Hygiene Program, Mohammad J. Alzahrani

Dental Hygiene Theses & Dissertations

The purpose of this study was to measure the utility of a variety of predictors that have been used by the Old Dominion University, Gene W. Hirschfeld School of Dental Hygiene and other baccalaureate dental hygiene programs in selecting dental hygiene students who are most likely to graduate and be successful in passing the National Board Dental Hygiene Examination (NBDHE). Specifically this study attempted to determine whether or not the following factors are reliable predictors of success in a an entry-level baccalaureate dental hygiene program as evidenced by graduation and successful entry into the profession as evidenced by passing the …

Hiv/Aids And Condom Usage: Factors That Contribute To African American Women's Vulnerability To Hiv Infection, Monica P. Washington

Sociology & Criminal Justice Theses & Dissertations

HIV/AIDS poses an enormous health threat to African Americans, specifically African American women. According to the Center for Disease Control "1 in 160 African American women are believed to be infected with HIV (Center for Disease Control 1999:1). In 2000, although African American women only represented 12% of the female population, they accounted for 64% of HIV cases reported among women (The White House 2000; National Institute of Allergy and Infectious Diseases 2004).

This study examined HIV/AIDS and African American women and attempted to answer the question: Why are African American women not consistently using condoms to protect themselves against …

Symptoms Of Gastro-Oesophageal Reflux Disease And The Severity Of Obstructive Sleep Apnoea Syndrome Are Not Related In Sleep Disorders Center Patients, H.-N. Kim, R. D. Vorona, M. P. Winn, M. Doviak, D. A. Johnson, J. Catesby Ware

Mathematics & Statistics Faculty Publications

Background: Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship.

Aim: To determine the relationship between OSAS and symptoms of GERD.

Methods: Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between OSAS severity categories and presence of GERD; 3) examining GERD score in …

A Comparison Of Esomeprazole And Lansoprazole For Control Of Intragastric Ph In Patients With Symptoms Of Gastro-Oesophageal Reflux Disease, D. A. Johnson, T. Stacy, M. Ryan, T. Wootton, J. Willia, K. Hornbuckle, W. Brooks, M. Doviak

Mathematics & Statistics Faculty Publications

Background: Intragastric acid suppression is the most direct measure of the pharmacodynamic efficacy of proton pump inhibitors, which are the most effective drugs for acid-related diseases.

Aim: To compare the effectiveness of once and twice daily dosing of lansoprazole and esomeprazole in controlling intragastric acidity ( target gastric pH > 4.0) over a 24-hour period.

Methods: In an open-label, two-way crossover study, 45 Helicobacter pylori-negative patients with gastro-oesophageal reflux disease were randomized to receive one of two regimens: 30 mg lansoprazole or esomeprazole 40 mg once daily. Intragastric pH was assessed by 24-hour pH monitoring on day 5 of each regimen. …

Enhancing The Geriatric Competence Of Urologic Nurses, Karen A. Karlowicz

Nursing Faculty Publications

Editorial. Provides strategies for enhancing the geriatric competence of urologic nurses. Improvements in nursing practice and in other health care professions; Considerations in caring for older adults; Implications for nursing practice.

Dietary Supplements And Sports Performance: Minerals, Melvin H. Williams

Human Movement Studies & Special Education Faculty Publications

Minerals are essential for a wide variety of metabolic and physiologic processes in the human body. Some of the physiologic roles of minerals important to athletes are their involvement in: muscle contraction, normal hearth rhythm, nerve impulse conduction, oxygen transport, oxidative phosphorylation, enzyme activation, immune functions, antioxidant activity, bone health, and acid-base balance of the blood. The two major classes of minerals are the macrominerals and the trace elements. The scope of this article will focus on the ergogenic theory and the efficacy of such mineral supplementation. Journal of the International Society of Sports Nutrition. 2( 1): 43-49, 2005.

Dietary Supplements And Sports Performance: Amino Acids, Melvin H. Williams

Human Movement Studies & Special Education Faculty Publications

This is the third in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations). The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

Effects Of Ultrasonic Scaling And Hand-Activated Scaling On Tactile Sensitivity In Dental Hygiene Students, Danielle L. Ryan, Michele Darby, Susan L. Tolle, Deborah Bauman, Dayanand Naik

Dental Hygiene Faculty Publications

Purpose. This study was conducted to determine if tactile sensitivity varies in dental hygiene students who use the ultrasonic scaler, as compared to those who scale with hand-activated instruments.

Methods. A two-group, randomized subjects, pretest-posttest design was carried out mid-semester for five weeks on 40 first-year dental hygiene students who met the inclusion criteria of this study and who agreed to participate. A convenience sample of 40 consenting, first-year dental hygiene students were randomly assigned to one of two groups (experimental or control). After establishing a baseline tactile sensitivity score with the Vibratory Sensory Analyzer (VSA), experimental group subjects used …

Improving Clinical Practice Using Clinical Decision Support Systems: A Systematic Review Of Trials To Identify Features Critical To Success, Kensaku Kawamoto, Caitlin A. Houlihan, E. Andrew Balas, David F. Lobach

School of Medical Diagnostics & Translational Sciences Faculty Publications

Objective To identify features of clinical decision support systems critical for improving clinical practice. Design Systematic review of randomised controlled trials.
Data sources Literature searches via Medline, CINAHL, and the Cochrane Controlled Trials Register up to 2003; and searches of reference lists of included studies and relevant reviews.
Study selection Studies had to evaluate the ability of decision support systems to improve clinical practice.
Data extraction Studies were assessed for statistically and clinically significant improvement in clinical practice and for the presence of 15 decision support system features whose importance had been repeatedly suggested in the literature.
Results Seventy studies …

Factors That Influence Mammography Use Of Community Health Workers, Cynthia M. Kratzke

Health Services Research Dissertations

Community health worker (CHW) interventions promote early detection of breast cancer and mammography use to help eliminate health disparities for minority and low-income women. Data trends show lower mammography use among this population although CHW interventions have been shown to promote mammography use. However, CHW interventions have not been tested sufficiently to examine the factors that influence mammography use of CHWs.

This cross-sectional study examined the factors that influence mammography use of CHWs and the relationship of self-efficacy, social norms, and mammography use of CHWs. The PRECEDE model served as the framework combining social factors, beliefs, attitudes, behaviors, and accessibility …

Survey Of Camera Phone Awareness In Outpatient Community Behavioral Health Facilities, Tara Lynn Overton

Community & Environmental Health Theses & Dissertations

The purpose of this study was to determine the level of camera phone awareness in outpatient community behavioral health facilities in a medium sized Mid-Atlantic state. Camera phones have been shown to have a detrimental effect on the protection of privacy in areas such as corporations, gym locker rooms, and court houses, but privacy issues have not yet been addressed in behavioral health. Privacy is an important issue in healthcare as shown through the implementation of the Health Insurance Portability and Accountability Act (HIPAA). This study used Rogers' (1995) Diftbsion of Innovations Theory as a framework for determining the stage …

Nanosecond Pulsed Electric Fields: A New Stimulus To Activate Intracellular Signaling, Stephen J. Beebe, Karl H. Schoenbach

Bioelectrics Publications

When new technologies are introduced into the scientific community, controversy is expected and both excitement and disappointment enrich the lives of those who initiate the new ideas. It becomes the mission of the “inventors” to embrace the burden of proof to establish their ideas and convince the skeptics and disbelievers who will undoubtedly temper their enthusiasm and test their patience. While open mindedness is generally a scientific motto, those who review patents, manuscripts, and grants do not always readily practice it, even when the evidence is convincingly presented; old ideas and concepts often die hard. So it has been and …

Simulations Of Nanopore Formation And Phosphatidylserine Externalization In Lipid Membranes Subjected To A High-Intensity, Ultrashort Electric Pulse, Q. Hu, R. P. Joshi, K. H. Schoenbach

Bioelectrics Publications

A combined MD simulator and time dependent Laplace solver are used to analyze the electrically driven phosphatidylserine externalization process in cells. Time dependent details of nanopore formation at cell membranes in response to a high-intensity (100kV∕cm), ultrashort (10ns) electric pulse are also probed. Our results show that nanosized pores could typically be formed within about 5ns. These predictions are in very good agreement with recent experimental data. It is also demonstrated that defect formation and PS externalization in membranes should begin on the anode side. Finally, the simulations confirm that PS externalization is a nanopore facilitated event, rather than the …

Men, Muscles, And Body Image: Comparisons Of Competitive Bodybuilders, Weight Trainers, And Athletically Active Controls, T. C. Pickett, R. J. Lewis, T. F. Cash, H. G. Pope

Psychology Faculty Publications

Objectives: To investigate body image and psychosocial adjustment among competitive bodybuilders, non-competitive weight trainers, and athletically active men.

Methods: Participants were 40 men in each of the three groups who were assessed on body composition and multiple facets of body image evaluation, investment and anxiety, eating attitudes, and social self esteem.

Results: Relative to the other two groups, competitive bodybuilders had greater body mass due to fat-free body mass. Although groups did not differ in their situational body image discomfort, competitive bodybuilders and weight trainers had a more positive global appearance evaluation and were more psychologically invested in their physical …