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Articles 1 - 24 of 24
Full-Text Articles in Medicine and Health Sciences
A Psychopharmacology Review Of Brexpiprazole, Nicole A. Marion
A Psychopharmacology Review Of Brexpiprazole, Nicole A. Marion
Conspectus Borealis
Brexpiprazole is an antipsychotic drug often used to help treat schizophrenia and major depressive disorder. This review paper breaks down the drugs history including what it is used for, how it is used, and how it was developed. Pharmacokinetics including administration routes, steady states, and metabolism. This review also describes pharmacodynamics, focusing on drug affinity. It will also discuss pharmacological effects pulling evidence from clinical trials. Last this review will describe the toxicology and safety of brexpiprazole.
Evaluation Of A Hands-On Cooking Class And Its Effects On Self-Efficacy In Relation To Healthy Eating In Type 2 Diabetics, Codi A. Jenshak-Gorzinski
Evaluation Of A Hands-On Cooking Class And Its Effects On Self-Efficacy In Relation To Healthy Eating In Type 2 Diabetics, Codi A. Jenshak-Gorzinski
DNP Scholarly Projects
The prevalence of Type 2 diabetes is alarming and poses a great threat to U.S. national health. Chronic diabetes can lead to serious conditions such as heart attack and stroke, and can result in premature mortality (World Health Organization, 2018). Diabetes can be prevented or treated by eating a healthy diet. Cooking classes are a potential way to improve American’s knowledge of nutritional principles and help them become confident that they have the capacity to eat a healthy diet. The purpose of this DNP project was to determine if participation in cooking classes enhanced self-efficacy as it pertains to healthy …
Coordination Variability And Injury Risk In Experienced Collegiate Dancers, Emily Klinkman
Coordination Variability And Injury Risk In Experienced Collegiate Dancers, Emily Klinkman
All NMU Master's Theses
Dance is a sport that places a number of physical demands upon the human body, and injuries are a common occurrence in the sport. While it has not yet been linked to dance-related injury, coordination variability (CV) is a measure of how much movement strategy changes between repetitions of a task and low levels of CV have been linked to injury in other sports. This study aimed to determine the relationship between CV and dance injury in collegiate dancers. Eight (8) undergraduate student subjects were recruited from the dance major and minor, BFA major and minor, and recreational dancers who …
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
All NMU Master's Theses
Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …
The Physiological Effects Of Therapy Dogs During Exercise For Sedentary Adults, Josie Lynne Mazzone
The Physiological Effects Of Therapy Dogs During Exercise For Sedentary Adults, Josie Lynne Mazzone
All NMU Master's Theses
Previous research has shown therapy dogs may be utilized to attenuate heart rate (HR) and blood pressure (BP) responses during various types of stressors due to an increase in oxytocin (OT) and decrease in cortisol (CL) production. These hormonal changes have also been shown to enhance exercise performance. Purpose: This study aimed to determine if physiological responses to exercise changed in the presence of a therapy dog for sedentary adults. Methods: Seven adult subjects (mean age of 30.86 ± 14.07 years) who self-reported less than 150 min of physical activity per week participated in a graded walking test with a …
Trial Of Newgait System To Alter Running Mechanics In High School Athlete: A Case Report, Kathy Tooman, Jozie Weiler, Stacy Ruotsala, Sarah Breen
Trial Of Newgait System To Alter Running Mechanics In High School Athlete: A Case Report, Kathy Tooman, Jozie Weiler, Stacy Ruotsala, Sarah Breen
Other
Trial of NewGait System to Alter Running Mechanics in High School Athlete: a Case Report
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
All NMU Master's Theses
Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent antitumor activity, blood-brain barrier permeability, and capability for tumor-specific drug deliverance and intraoperative visualization (termed theranostic) were of focus. Confocal microscopy was employed to characterize in vitro specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of extracellular matrix metalloproteinase inducer (EMMPRIN; Basigin) isoform …
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
All NMU Master's Theses
Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor …
The Effect Of High Altitude On Central Blood Pressure And Arterial Stiffness, Christopher Boos, Emmanuel Vincent, Adrian Mellor, David Woods, Caroline Newman, Richard Cruttenden, Matt Barlow, Mark Cooke, Kevin Deighton, Peter Scott, Sarah B. Clarke, John O'Hara
The Effect Of High Altitude On Central Blood Pressure And Arterial Stiffness, Christopher Boos, Emmanuel Vincent, Adrian Mellor, David Woods, Caroline Newman, Richard Cruttenden, Matt Barlow, Mark Cooke, Kevin Deighton, Peter Scott, Sarah B. Clarke, John O'Hara
Journal Articles
No abstract provided.
Molecular Subtyping Of Staphylococcus Aureus Isolates From The U.P. Community For The Presence Of Toxin-Encoding Genes, Carol I. Kessel
Molecular Subtyping Of Staphylococcus Aureus Isolates From The U.P. Community For The Presence Of Toxin-Encoding Genes, Carol I. Kessel
All NMU Master's Theses
Staphylococcus aureus is the most common cause of human bacterial infections; however, humans can also be asymptomatically colonized with S. aureus. Asymptomatic carriers can potentially spread S. aureus infection to others. These infections can range from mild to severe. The pathology of a S. aureus infection is often dependent on which toxins are expressed and the virulence factors with which they are associated. One goal of this study was to isolate S. aureus from healthy, consenting adult volunteers who submitted nasal swabs for culture and qRT-PCR analysis to determine which strains are present in the community. This knowledge could …
Changes In Balance And Joint Position Sense During A 12-Day High Altitude Trek: The British Services Dhaulagiri Medical Research Expedition, Sarah B. Clarke
Changes In Balance And Joint Position Sense During A 12-Day High Altitude Trek: The British Services Dhaulagiri Medical Research Expedition, Sarah B. Clarke
Datasets
Postural control and joint position sense are essential for safely undertaking leisure and professional activities, particularly at high altitude. We tested whether exposure to a 12-day trek with a gradual ascent to high altitude impairs postural control and joint position sense. This was a repeated measures observational study of 12 military service personnel (28±4 years). Postural control (sway velocity measured by a portable force platform) during standing balance, a Sharpened Romberg Test and knee joint position sense were measured, in England (113m), and at 3 research camps (3619m, 4600m and 5140m) on a 12-day high altitude trek in the Dhaulagiri …
British Services Dhaulagiri Medical Research Expedition: A Unique Military And Civilian Research Collaboration, Adrian Mellor, Josh Bakker-Dyos, Marc Howard, Christopher Boos, Mark Cooke, Emmanuel Vincent, Peter Scott, John O'Hara, Sarah B. Clarke, Matt Barlow, Jamie Matu, Kevin Deighton, Caroline Newman, Richard Cruttenden, David Holdsworth, David Woods
British Services Dhaulagiri Medical Research Expedition: A Unique Military And Civilian Research Collaboration, Adrian Mellor, Josh Bakker-Dyos, Marc Howard, Christopher Boos, Mark Cooke, Emmanuel Vincent, Peter Scott, John O'Hara, Sarah B. Clarke, Matt Barlow, Jamie Matu, Kevin Deighton, Caroline Newman, Richard Cruttenden, David Holdsworth, David Woods
Journal Articles
No abstract provided.
Changes In Appetite, Energy Intake, Body Composition And Circulating Ghrelin Constituents During An Incremental Trekking Ascent To High Altitude, Jamie Matu, John O'Hara, Neil Hill, Sarah B. Clarke, Christopher Boos, Caroline Newman, David Holdsworth, Theocharis Ispoglou, Lauren Duckworth, David Woods, Adrian Mellor, Kevin Deighton
Changes In Appetite, Energy Intake, Body Composition And Circulating Ghrelin Constituents During An Incremental Trekking Ascent To High Altitude, Jamie Matu, John O'Hara, Neil Hill, Sarah B. Clarke, Christopher Boos, Caroline Newman, David Holdsworth, Theocharis Ispoglou, Lauren Duckworth, David Woods, Adrian Mellor, Kevin Deighton
Journal Articles
No abstract provided.
A Novel And Rapid Staphylococcus Aureus Bacterial Identification Method Utilizing Immunomagnetic Beads And Single Cell Laser-Light Scattering, Kaylagh Hollen
A Novel And Rapid Staphylococcus Aureus Bacterial Identification Method Utilizing Immunomagnetic Beads And Single Cell Laser-Light Scattering, Kaylagh Hollen
All NMU Master's Theses
Staphylococcus aureus is the most commonly isolated human associated bacterial pathogen. It plays an important role in skin and soft-tissue infections, pneumonia, endocarditis, osteomyelitis, foreign-body infections, and sepsis. S. aureus diagnosis and treatment requires a minimum of 24-48. With this in mind, previous studies suggest that faster pathogen identification has been linked to improved patient outcomes. Improved patient outcomes including a reduction in hospitalization time, decreased risk of nosocomial infections, and decreased in medical costs. The impact of faster identification on patient outcome has led us to develop an alternative method of S. aureus identification via ImmunoMagnetic Separation (IMS) and …
Reactive Strength Index-Modified In Different Plyometric Tasks, Josh Walker, Sarah B. Clarke, Emma Waller, Aaron Robey-Broome, Randall L. Jensen
Reactive Strength Index-Modified In Different Plyometric Tasks, Josh Walker, Sarah B. Clarke, Emma Waller, Aaron Robey-Broome, Randall L. Jensen
Conference Presentations
No abstract provided.
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
All NMU Master's Theses
Neurotensin (NT) is a peptide neurotransmitter that interacts with brain monoamine neurotransmitter systems. It has been demonstrated that neurotensin type 1 and type 2 receptor agonists influence animal models of psychological disorders and pain regulation, respectively. It has already been shown that the systemic administration of the selective neurotensin type 1 receptor agonist PD149163 can attenuate the number of fear-induced 22-kHz ultrasonic vocalizations (USVs) produced by male Wistar rats. A reduction in the number of 22-kHz USV calls is indicative of an anxiolytic effect. The current study used a USV model to evaluate the effects of PD149163 (0.1, 1.0, and …
The Acute Effects Of The Prevent Injury Enhance Performance Programme (Pep) On Acl Injury Risk Factors, Chris Mccann, Sarah B. Clarke
The Acute Effects Of The Prevent Injury Enhance Performance Programme (Pep) On Acl Injury Risk Factors, Chris Mccann, Sarah B. Clarke
Conference Presentations
No abstract provided.
Lower Limb Coordination During A Land-Cut Task Following Anterior Cruciate Ligament Reconstruction And Rehabilitation, Sarah B. Clarke, Ian Kenny, Andrew Harrison
Lower Limb Coordination During A Land-Cut Task Following Anterior Cruciate Ligament Reconstruction And Rehabilitation, Sarah B. Clarke, Ian Kenny, Andrew Harrison
Conference Presentations
No abstract provided.
Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv
Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv
All NMU Master's Theses
Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general locomotor activity as measured in an open field test. The present study sought to examine the effects of the neurotensin NTS1 receptor agonist PD149163 and the tricyclic antidepressant drug imipramine on immobility in the forced swim test and on locomotor activity …
Changes In Running Gait Parameters During A 161 Km Trail Race, Sarah Breen, Mitchell Stephenson, Randall L. Jensen, Scott Drum
Changes In Running Gait Parameters During A 161 Km Trail Race, Sarah Breen, Mitchell Stephenson, Randall L. Jensen, Scott Drum
Conference Presentations
No abstract provided.
Comparison Of Kinematics And Accuracy Of Overhand American Football Throwing, Cale Anderson, Sarah Breen, Randall L. Jensen
Comparison Of Kinematics And Accuracy Of Overhand American Football Throwing, Cale Anderson, Sarah Breen, Randall L. Jensen
Conference Presentations
No abstract provided.
An Introduction To Drugs And The Neuroscience Of Behavior, Adam J. Prus
An Introduction To Drugs And The Neuroscience Of Behavior, Adam J. Prus
Books
This up-to-date text provides an introductory overview of the nervous system actions and behavioral effects of the major classes of psychoactive drugs, using pedagogy unique among pharmacology texts to make the topic approachable.
A Study To Investigate The Reliability And Consistency Of The Sports Tutor Tennis Cube Velocity, Trajectory And Landing Points, Michelle Norris, Sarah Breen, Ross Anderson, Ian Kenny
A Study To Investigate The Reliability And Consistency Of The Sports Tutor Tennis Cube Velocity, Trajectory And Landing Points, Michelle Norris, Sarah Breen, Ross Anderson, Ian Kenny
Conference Presentations
No abstract provided.
The Development Of A New Protocol To Assess Performance Measure In Sports, Michelle Norris, Sarah Breen, Ross Anderson, Ian Kenny
The Development Of A New Protocol To Assess Performance Measure In Sports, Michelle Norris, Sarah Breen, Ross Anderson, Ian Kenny
Conference Presentations
No abstract provided.