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Full-Text Articles in Medicine and Health Sciences

Identifying Blood Biomarkers And Physiological Processes That Distinguish Humans With Superior Performance Under Psychological Stress., Amanda M. Cooksey, Nausheen Momen, Russell Stocker, Shane C. Burgess Dec 2009

Identifying Blood Biomarkers And Physiological Processes That Distinguish Humans With Superior Performance Under Psychological Stress., Amanda M. Cooksey, Nausheen Momen, Russell Stocker, Shane C. Burgess

College of Veterinary Medicine Publications and Scholarship

BACKGROUND: Attrition of students from aviation training is a serious financial and operational concern for the U.S. Navy. Each late stage navy aviator training failure costs the taxpayer over $1,000,000 and ultimately results in decreased operational readiness of the fleet. Currently, potential aviators are selected based on the Aviation Selection Test Battery (ASTB), which is a series of multiple-choice tests that evaluate basic and aviation-related knowledge and ability. However, the ASTB does not evaluate a person's response to stress. This is important because operating sophisticated aircraft demands exceptional performance and causes high psychological stress. Some people are more resistant to …


Zebrafish Kidney Phagocytes Utilize Macropinocytosis And Ca+-Dependent Endocytic Mechanisms., Claudia Hohn, Sang-Ryul Lee, Lesya M. Pinchuk, Lora Petrie-Hanson Feb 2009

Zebrafish Kidney Phagocytes Utilize Macropinocytosis And Ca+-Dependent Endocytic Mechanisms., Claudia Hohn, Sang-Ryul Lee, Lesya M. Pinchuk, Lora Petrie-Hanson

College of Veterinary Medicine Publications and Scholarship

BACKGROUND: The innate immune response constitutes the first line of defense against invading pathogens and consists of a variety of immune defense mechanisms including active endocytosis by macrophages and granulocytes. Endocytosis can be used as a reliable measure of selective and non-selective mechanisms of antigen uptake in the early phase of an immune response. Numerous assays have been developed to measure this response in a variety of mammalian and fish species. The small size of the zebrafish has prevented the large-scale collection of monocytes/macrophages and granulocytes for these endocytic assays. METHODOLOGY/PRINCIPAL FINDINGS: Pooled zebrafish kidney hematopoietic tissues were used as …